  Le Locked-In Syndrome : la conscience emmuréeBruno, Marie-Aurélie  ; ; Schnakers, Caroline et alin Revue Neurologique (2008), 164 The Locked-In syndrome(LIS) is defined by: (i) the presence of sustained eye opening (bilateral ptosis should be ruled out as a complicating factor);(ii) preserved awareness; (iii) aphonia or hypophonia ... [more ▼] The Locked-In syndrome(LIS) is defined by: (i) the presence of sustained eye opening (bilateral ptosis should be ruled out as a complicating factor);(ii) preserved awareness; (iii) aphonia or hypophonia; (iv) quadriplegia or quadriparesis; and (v) a primary mode of communication that uses vertical or lateral eye movement or blinking. Acute ventral pontine lesions are its most common cause. Following such brainstem lesions patients may remain comatose for sometime and then gradually awaken, remaining paralyzed and voiceless, superficially resembling the vegetative state. Background. – It has been shown that more than half of the time physicians fail to recognize early signs of awareness in LIS. Given appropriate medical care,life expectancy may be several decades but the chances of good motor recovery remain small. Eye-controlled computer technology now allows LIS patients to communicate and control their environment. Recent studies show that most LIS patients self-report meaningful quality of life and the demand for euthanasia is infrequent. Conclusion. – Patients suffering from LIS should not be denied the right to die – and to die with dignity –but also they should not be denied the right to live–and to live with dignity and the best possible pain and symptom management and revalidation. [less ▲] Detailed reference viewed: 16 (11 ULg)Quelle vie apres le Locked-In syndrome?Bruno, Marie-Aurélie ; ; et alin Revue Médicale de Liège (2008), 63(5-6), 445-51 The Locked-In Syndrome (LIS) is classically caused by an anterior pontine vascular lesion and characterized by quadriplegia and anarthria with preserved consciousness and intellectual functioning. We here ... [more ▼] The Locked-In Syndrome (LIS) is classically caused by an anterior pontine vascular lesion and characterized by quadriplegia and anarthria with preserved consciousness and intellectual functioning. We here review the definition, etiologies, diagnosis and prognosis of LIS patients and briefly discuss the few studies on their quality of life and the challenging end-of-life decisions that can be encountered. Some clinicians may consider that LIS is worse than being in a vegetative or in a minimally conscious state. However, preliminary data from chronic LIS survivors show a surprisingly preserved self-scored quality of life and requests of treatment withdrawal or euthanasia, though not absent, are infrequent. [less ▲] Detailed reference viewed: 78 (12 ULg)Brain response to one's own name in vegetative state, minimally conscious state and locked-in syndrome; Schnakers, Caroline ; et alin Archives of Neurology (2006), 63 Detailed reference viewed: 31 (6 ULg)Imagine imaging neural activity in crying infants and in their caring parentsLaureys, Steven ; in Behavioral and Brain Sciences (2004), 27(4), 465 Soltis' paper contains little data on the underlying neural substrate of the discussed signal function of early infant crying-probably because there is amazingly little known about it. We here discuss the ... [more ▼] Soltis' paper contains little data on the underlying neural substrate of the discussed signal function of early infant crying-probably because there is amazingly little known about it. We here discuss the interest of functional neuroimaging as an objective measurement of brain activity in (1) early infants during crying and (2) parents hearing their offspring cry. [less ▲] Detailed reference viewed: 15 (1 ULg)Impaired cerebral connectivity in vegetative stateLaureys, Steven ; Faymonville, Marie ; et alin Physiological imaging of the brain with PET (2000) Detailed reference viewed: 33 (1 ULg)5-HT1A Receptors visualization with p-[18F]MPPF in healthy volunteers.Plenevaux, Alain ; Lemaire, Christian ; Salmon, Eric et alin Journal of Labelled Compounds & Radiopharmaceuticals (1999), 42 Detailed reference viewed: 9 (2 ULg)In vivo studies of p-[18F]MPPF metabolites in human.; Plenevaux, Alain ; Lemaire, Christian et alin Journal of Labelled Compounds & Radiopharmaceuticals (1999), 42 Detailed reference viewed: 5 (2 ULg) |
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