 Specific transcription factors regulate the c-erbB2 expression in the tumor BT-474 mammary cells.; Pasleau, Françoise  ; Conference (1995, March 24) Detailed reference viewed: 2 (0 ULg)Specific transcription factors of the tumor BT-474 mammary cells regulate the c-erbB2 gene expression.; Pasleau, Françoise ; Conference (1994, December 22) Detailed reference viewed: 7 (0 ULg)The 6 kb c-erbB2 promoter contains positive and negative regulatory elements functional in human mammary cell lines.; Pasleau, Françoise ; et alConference (1994, September) Detailed reference viewed: 12 (2 ULg)La région régulatrice du gène c-erbB2 contient des éléments cis-activateurs et inhibiteurs actifs dans des lignées de cellules épithéliales mammaires humaines.; Pasleau, Françoise ; et alConference (1994, June) Detailed reference viewed: 1116 (0 ULg)Régulation de l'expression de l'oncogène c-erbB2 dans les cancers mammaires humains.; Pasleau, Françoise ; et alConference (1994, May 06) Detailed reference viewed: 32 (0 ULg)The c-erbB2 upstream regulatory region contains positive and negative cis-acting elements differentially active in human mammary tumor cell lines.; Pasleau, Françoise ; et alConference (1994, January 29) Detailed reference viewed: 6 (1 ULg)Breast-specific expression of erbB2-LUC reporter genes.Pasleau, Françoise ; ; et alConference (1993, November 11) Detailed reference viewed: 8 (1 ULg)Molecular alterations in breast cancers : deregulation of c-erbB2 gene expression.; Pasleau, Françoise ; et alConference (1993, September) Detailed reference viewed: 12 (0 ULg) Expression of the C-Erbb2 Gene in the Bt474 Human Mammary Tumor Cell Line: Measurement of C-Erbb2 Mrna Half-LifePasleau, Françoise ; ; in Oncogene (1993), 8(4), 849-54 BT474 and SK-BR-3 mammary adenocarcinoma cells contain eight copies of the c-erbB2 gene but overexpress the mRNA 80 times over the levels measured in normal breast or in the HBL-100 cell line. Using ... [more ▼] BT474 and SK-BR-3 mammary adenocarcinoma cells contain eight copies of the c-erbB2 gene but overexpress the mRNA 80 times over the levels measured in normal breast or in the HBL-100 cell line. Using Northern blot analysis and molecular titration based on RNAase protection assay, the decrease in the c-erbB2 mRNA level was monitored in BT474 cells treated with actinomycin D from 1 up to 24 h. The c-erbB2 degradation rate during the first 12 h corresponds to a calculated c-erbB2 mRNA half-life of approximately 7 h. Forty percent of the mRNA present in the cells before treatment remains undegraded after transcription has been blocked for 24 h. Pretreatment with cycloheximide results in complete mRNA degradation in 24 h, suggesting that labile proteins stabilize part of the c-erbB2 mRNA population. Comparison with the c-erbB2 mRNA turnover in HBL-100 'normal' cells indicated that the accumulation of the c-erbB2 gene product in the tumor cells is not the result of stabilization of the messenger. Rather, it is correlated with an increased rate of c-erbB2 mRNA transcription as indicated by run-on transcription assays. Both BT474 and SK-BR-3 tumor cell lines were found to synthesize 20-40 times more c-erbB2 mRNA than HBL-100 cells. [less ▲] Detailed reference viewed: 34 (0 ULg)Caractérisation des altérations moléculaires responsables de la surexpression du gène c-erbB2 dans les cancers du sein.; Pasleau, Françoise ; et alConference (1993, March 26) Detailed reference viewed: 16 (4 ULg)Etude de l'expression de l'oncogène c-erbB2 dans les cellules épithéliales mammaires humaines "normales" HBL-100 et tumorales BT-474.; Pasleau, Françoise ; Conference (1992, November 24) Detailed reference viewed: 23 (1 ULg)Tissue-specific expression of c-erbB2-LUC reporter genes transiently transfected in cervix adenocarcinoma HeLa cells or in "normal" HBL-100 or tumor BT474 mammary epithelial cell lines.Pasleau, Françoise ; ; et alPoster (1992, June) Detailed reference viewed: 7 (1 ULg)Expression transitoire du promoteur c-erbB2 dans les cellules épithéliales mammaires normales et tumorales en culture.; Pasleau, Françoise ; et alConference (1992, February) Detailed reference viewed: 27 (1 ULg)Regulation of the expression of the c-erbB2 gene, an adenocarcinoma specific oncogene, in cultured human mammary cancer cell lines : a molecular approach.Pasleau, Françoise ; ; Conference (1991, September) Detailed reference viewed: 3 (0 ULg)Les oncogènes dans les cancers du sein.; Pasleau, Françoise ; Conference (1990) Detailed reference viewed: 44 (2 ULg) |
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