A review of dietary and non-dietary exposure to bisphenol-A.

in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (2012), 50(10), 3725-40

Due to the large number of applications of bisphenol-A (BPA), the human exposure routes are multiple. We aimed to review shortly the food and non-food sources of BPA, and to evaluate their contribution to ... [more ▼]

Due to the large number of applications of bisphenol-A (BPA), the human exposure routes are multiple. We aimed to review shortly the food and non-food sources of BPA, and to evaluate their contribution to the human exposure. Food sources discussed here include epoxy resins, polycarbonate and other applications, such as paperboard and polyvinylchloride materials. Among the non-food sources, exposures through dust, thermal paper, dental materials, and medical devices were summarized. Based on the available data for these exposure sources, it was concluded that the exposure to BPA from non-food sources is generally lower than that from exposure from food by at least one order of magnitude for most studied subgroups. The use of urinary concentrations from biomonitoring studies was evaluated and the back-calculation of BPA intake seems reliable for the overall exposure assessment. In general, the total exposure to BPA is several orders of magnitude lower than the current tolerable daily intake of 50 mug/kg bw/day. Finally, the paper concludes with some critical remarks and recommendations on future human exposure studies to BPA. [less ▲]

Evaluation of the use of CALUX-results for dioxins and dioxin-like PCBs analysis for quantitative human exposure assessments

in Food Control (2012), 27(2), 314-321

NEW CUT-OFF VALUES FOR APPLICATIONS IN BIOANALYTICAL SCREENING: DECISION OVER SAMPLE COMPLIANCE WITH LEGAL LIMITS SET BY THE EUROPEAN UNION FOR PCDD/Fs AND DIOXIN-LIKE PCBs.

in Organohalogen Compounds (2010), 72

ANALYSIS OF DIOXINS AND DIOXIN-LIKE PCBS IN HOME PRODUCED EGGS: LEVELS AND SOURCES

in Organohalogen Compounds (2008)

Validation and interpretation of CALUX as a tool for the estimation of dioxin-like activity in marine biological matrixes.

in Environmental Science & Technology (2005), 39(6), 1741-1748

Among the different analytical tools proposed as an alternative to the very expensive gas chromatography high-resolution mass spectrometry (GC-HRMS) analyses of polychlorodibenzo-p-dioxin and ... [more ▼]

Among the different analytical tools proposed as an alternative to the very expensive gas chromatography high-resolution mass spectrometry (GC-HRMS) analyses of polychlorodibenzo-p-dioxin and polychlorodibenzofurans, Chemically Activated LUciferase gene eXpression (CALUX) in vitro cell bioassay is very promising. It allows the analyses of a high number of samples since it is relatively fast, inexpensive, and sensitive. However, this technique is not yet widely applied for screening or environmental monitoring. The main reasons are probably the lack of validation and the difficulty in interpreting the global biological response of the bioassay. In this paper, the strict quality control criteria set up for the validation of CALUX are described. The validation has shown good repeatability (relative standard deviation (RSD) = 9%) and good within-lab reproducibility (RSD = 15%) of the results. The quantification limit, in the conditions applied in this paper, is 1.25 pg CALUX-TEQ/g fat. Comparison of CALUX and GC-HRMS analysis was made for various marine matrixes (fishes, mussels, starfishes, sea birds, and marine mammals). Good correlations are usually observed, but there are systematic differences between the results. Attempts are made to identify the origin of the discrepancy between the two methods. [less ▲]

Comparison of the rat and mouse cell lines commercially available for CALUX bioassays

in Organohalogen compounds (2004), 66

Selective adsorption of dioxins and PCBs from marine oils on activated carbon

in Organohalogen Compounds (2003)

Nutrient depletions in the Ross Sea and their relation with pigment stocks

in Journal of Marine Systems (2000), 27

The present article depicts a first attempt to relate the governing nutrient uptake regime and phytopigment signature of the Ross Sea. Based on nutrient and phytopigment data obtained during two cruises ... [more ▼]

The present article depicts a first attempt to relate the governing nutrient uptake regime and phytopigment signature of the Ross Sea. Based on nutrient and phytopigment data obtained during two cruises in the Ross Sea, two distinct groups were recognised. The first one was characterised by moderate nutrient nitrate and silicic acid depletions in combination with relatively high diatom and Phaeocystis abundance. The second group showed very low nutrient depletions and very poor diatom abundance. Average depth specific nitrate depletions were 8.1 and 1.1 μM and average silicic acid depletions were 21.5 and 1.3 μM, respectively. The nutrient consumption patterns did not match the conditions of silicic acid excess (SEA) or nitrate excess areas (NEA), a clear trend being probably obscured by very poor seasonal maturity of several sampling stations. The contrast between both groups is largely explained by small differences in nitrogen uptake regime of the major phytoplankters. During early season, the diatoms meet the majority of their nitrogen requirements by nitrate uptake, with few exceptions where ammonium is the most important nitrogenous substrate. On average, their nitrate uptake capacity is lower than that of Phaeocystis (average specific nitrate uptake rates were 0.021 and 0.036 day y-1 for diatoms and Phaeocystis, respectively). The latter phytoplankton always shows predominance of nitrate uptake. Both groups are subject to inhibition of nitrate uptake when ammonium availability increases, and it is likely that the diatoms are more sensitive to the inhibitory effect of ammonium. [less ▲]