   TEL is a sequence-specific transcriptional repressor.; ; Oury, Cécile  et alin Journal of Biological Chemistry (1999) TEL is a gene frequently involved in specific chromosomal translocations in human leukemia and sarcoma that encodes a member of the ETS family of transcriptional regulators. TEL is unusual among other ETS ... [more ▼] TEL is a gene frequently involved in specific chromosomal translocations in human leukemia and sarcoma that encodes a member of the ETS family of transcriptional regulators. TEL is unusual among other ETS proteins by its ability to self-associate in vivo, a property that is essential to the oncogenic activation of TEL-derived fusion proteins. We show here that TEL is a sequence-specific transcriptional repressor of ETS-binding site-driven transcription of model and natural promoters. [less ▲] Detailed reference viewed: 3 (0 ULg) A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein.; ; et al in EMBO Journal (1997) TEL is a novel member of the ETS family of transcriptional regulators which is frequently involved in human leukemias as the result of specific chromosomal translocations. This study shows that the amino ... [more ▼] TEL is a novel member of the ETS family of transcriptional regulators which is frequently involved in human leukemias as the result of specific chromosomal translocations. This study shows that the amino-terminal domain conserved in a subset of the ETS proteins has evolved to generate a specialized protein-protein interaction interface which is likely to be an important determinant of their specificity as transcriptional regulators. [less ▲] Detailed reference viewed: 4 (0 ULg)The TEL gene products: nuclear phosphoproteins with DNA binding properties.; Oury, Cécile ; et alin Oncogene (1997) The human TEL gene is involved in several 12p13 chromosomal abnormalities present in various human hematological malignancies, the most frequent being the t(12;21)(p13;q22), specific for childhood acute ... [more ▼] The human TEL gene is involved in several 12p13 chromosomal abnormalities present in various human hematological malignancies, the most frequent being the t(12;21)(p13;q22), specific for childhood acute lymphoblastic leukemia. The predicted product of TEL harbours an amino acid region similar to the ETS DNA binding domain. We now report the isolation of the murine TEL cDNA and the characterization of the human TEL proteins. Human and murine TEL proteins are particularly homologous within their aminoterminal regions and their ETS domains. TEL proteins are nuclear and display specific DNA binding activity toward classical ETS binding sites. In addition, we show that TEL mRNAs initiate translation at either of the two first inframe ATGs (codon 1 and 43) to encode 50 kDa and 57 kDa TEL proteins. In vivo, each of these primary translational products is modified by multiple phosphorylation events. [less ▲] Detailed reference viewed: 2 (0 ULg)Monoclonal antibodie to hemagglutinin-neuraminidase and fusion glycoproteins of Newcastle Disease Virus : relationship between glycosylation and reactivity.; Portetelle, Daniel ; et alin Journal of Virology (1986), 57 Detailed reference viewed: 2 (0 ULg)Bovine Leukemia Virus (BLV) - A structural model based on chemical crosslinking studies; ; et al in Virology (1984), 133 Detailed reference viewed: 5 (0 ULg)Biologically active epitopes of Bovine Leukemia Virus glycoprotein gp51 : their dependence on protein glycosylation and genetic variability.; ; Portetelle, Daniel et alin Virology (1984), 136 Detailed reference viewed: 4 (1 ULg)Use of monoclonal antibodies in the study of BLV glycoprotein gp51.Portetelle, Daniel ; ; et alin Straub, O. C. (Ed.) Proceedings of the Fifth International Symposium on bovine leukosis (1984) Detailed reference viewed: 3 (0 ULg)Humoral antibody response to bovine leukemia virus infection in cattle and sheep.; ; et al in Cancer Research (1979), 39(3), 1118-1123 Detailed reference viewed: 6 (0 ULg)Large scale serological detection in Belgium of enzootic bovine leucosis.; ; et al in Zentralblatt für Veterinarmedizin. Reihe B = Journal of Veterinary Medicine. Series B (1978), 25 Detailed reference viewed: 8 (0 ULg)Morphogenesis of bovine leukemia virus (BLV).; ; et al in Burny, Arsène (Ed.) Bovine leukosis: various methods of molecular virology (1977) Detailed reference viewed: 5 (2 ULg)Comparative study of four diagnostic methods of enzootic bovine leukemia.; ; et al in Zentralblatt für Veterinarmedizin. Reihe B = Journal of Veterinary Medicine. Series B (1977), 24 Detailed reference viewed: 3 (0 ULg)Synthesis and complete processing of a high-molecular-weight precursor polypeptide to viral structural proteins in toad oocytes micro-injected with avian myeloblastosis virus ribonucleic acid.; ; et al in Biochemical Society Transactions (1977), 5 Detailed reference viewed: 8 (6 ULg)Frog oocytes synthesize and completely process the precursor polypeptide to virion structural proteins after microinjection of avian myeloblastosis virus; ; et al in Proceedings of the National Academy of Sciences of the United States of America (1977), 74(8), 3230-3234 Detailed reference viewed: 3 (0 ULg)Study on the diagnosis of enzootic bovine leukosis by complement fixation.; ; et al in Zentralblatt für Veterinarmedizin. Reihe B = Journal of Veterinary Medicine. Series B (1977), 24 Detailed reference viewed: 4 (0 ULg)Comparative study of four diagnostic methods of enzootic bovine leukemia.; ; et al in Burny, Arsène (Ed.) Bovine leucosis: various methods of molecular virology. (1977) Detailed reference viewed: 3 (0 ULg)Purification of bovine leukemia virus gp70 and bovine leukemia virus p24. Detection by radioimmunoassay of antibodies directed against these antigens.Portetelle, Daniel ; ; et alin Burny, Arsène (Ed.) Bovine leukosis: various methods of molecular virology (1977) Detailed reference viewed: 8 (0 ULg)Comparative study of two diagnostic methods of bovine leukosis : hématology and immunodiffusion.; Portetelle, Daniel ; Kettmann, Richard et alin Veterinary Microbiology (1976), 1 Detailed reference viewed: 3 (0 ULg)Bovine leukemia virus, an exogenous RNA oncogenic virus.Kettmann, Richard ; Portetelle, Daniel ; et alin Proceedings of the National Academy of Sciences of the United States of America (1976), 73 Detailed reference viewed: 4 (1 ULg)Diagnostic tests of bovine leukemia. Comparison between an hematological test and the serological diagnosis.; Portetelle, Daniel ; Kettmann, Richard et alin European Journal of Cancer (1976), 12 Detailed reference viewed: 2 (0 ULg)Bovine leukemia virus, an exogenous RNA oncogenic virus.Kettmann, Richard ; Portetelle, Daniel ; et alin Modern trends in human leukemia II (1976), 19 Detailed reference viewed: 2 (0 ULg) |
||
