References of "Gangl, Monika"
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See detailRelationship between biochemical markers and radiographic scores in the evaluation of the osteoarticular status of Warmblood stallions
Verwilghen, Denis ULg; Busoni, Valeria ULg; Gangl, Monika et al

in Research in Veterinary Science (2009), 87(2), 319-28

Establishing the osteoarticular status of the horse is often performed by means of radiological screening of the animals. Widespread blood sampling could reveal to be an interesting alternative to this ... [more ▼]

Establishing the osteoarticular status of the horse is often performed by means of radiological screening of the animals. Widespread blood sampling could reveal to be an interesting alternative to this procedure which is time consuming and sometimes technically difficult. The aim of this study was to investigate the relationship between the radiological status of the horses and the levels of biochemical markers of cartilage degradation and synovial inflammation. A specific radiological scoring and classification system was therefore developed and applied on 63 stallions presented for studbook admission. Additionally, groups of horses were established according to the occurrence of osteochondrosis, degenerative joint disease and distal interphalangeal joint effusion. Insulin growth factor-I, myeloperoxidases, Coll2-1 and Coll2-1NO(2) were used as blood markers. The combination of the blood parameters did not seem to correlate with the used scoring system. Coll2-1NO(2) levels however tended to increase with poorer radiological class and this could therefore potentially be a useful predictor of the osteoarticular status in the horse. Coll2-1 levels were significantly higher in the degenerative joint disease group. A high percentage of horses with distal interphalangeal joint effusion was present in this study and was associated with decreased IGF-I and increased Coll2-1 levels. [less ▲]

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See detailVariations of plasmatic concentrations of Insulin-like Growth Factor-I in post-pubescent horses affected with developmental osteochondral lesions.
Verwilghen, Denis ULg; Vander Heyden, Laurent ULg; Franck, Thierry ULg et al

in Veterinary Research Communications (2009)

Developmental osteochondral lesions are often encountered in the equine population and are a major cause of lameness. Different growth factors that act systemically as well as locally regulate the growth ... [more ▼]

Developmental osteochondral lesions are often encountered in the equine population and are a major cause of lameness. Different growth factors that act systemically as well as locally regulate the growth of cartilage. Among them is Insulin-like Growth Factor I that has been demonstrated to promote chondrocyte growth and differentiation and that has been shown to influence cartilage repair. The aims of this study were to investigate differences in circulating plasma levels of Insulin-like Growth Factor-I in post-pubescent horses affected with developmental osteochondral lesions compared to unaffected ones. Significantly higher values of circulating Insulin-like Growth Factor-I levels were found in the affected group (n = 82) compared to controls (n = 86). This result may still reflect an earlier imbalance in IGF-I levels from horses with developmental osteochondral lesions considering the aetiopathological link which has been made between IGF-I and the occurrence of osteochondrosis. However, other studies have shown increased expression of IGF-I after cartilage damage. The higher levels found in this study could be due to a healing response of the cartilage to the damage caused by the osteochondral lesions. [less ▲]

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See detailMyeloperoxidase Assay in Plasma and Peritoneal Fluid of Horses with Gastrointestinal Disease
Grulke, Sigrid ULg; Franck, Thierry ULg; Gangl, Monika et al

in Canadian Journal of Veterinary Research = Revue Canadienne de Recherche Vétérinaire (2008), 72(1), 37-42

Gastrointestinal disorders, especially strangulating intestinal obstructions, are still a major cause of illness and death in the horse. Circulating lipopolysaccharides may activate both neutrophils and ... [more ▼]

Gastrointestinal disorders, especially strangulating intestinal obstructions, are still a major cause of illness and death in the horse. Circulating lipopolysaccharides may activate both neutrophils and monocytes. The activated neutrophils release myeloperoxidase (MPO), a specific enzyme with strong oxidative activity. The aim of this study was to evaluate MPO concentrations in the plasma and peritoneal fluid (PF) of horses with colic and to check the hypothesis that these concentrations would be higher in a case of strangulating obstruction than in cases of nonstrangulating disease. By using a specific enzyme-linked immunosorbent assay for equine MPO, we determined the MPO concentrations in horses admitted to a clinic for colic. Horses with nonstrangulating or strangulating obstruction of the large intestine (NSLI or SLI), strangulating obstruction of the small intestine (SSI), or inflammatory bowel disease (IBD) were compared with healthy horses. The horses with SLI, SSI, or IBD had significantly higher MPO levels in plasma and PF than did those in the other 2 groups. The mean plasma level was significantly higher in the horses with NSLI than in the healthy horses. High MPO values in PF indicated necrotic bowel. These results show that neutrophil activation occurs during nonstrangulating and strangulating intestinal obstruction in horses and that the plasma and PF MPO concentrations may be a marker of the severity of the disease. [less ▲]

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See detailPlasma concentrations of a type II collagen-derived peptide and its nitrated form in growing ardenner sound horses and in horses suffering from juvenile digital degenerative osteoarthropathy
Lejeune, Jean-Philippe ULg; Serteyn, Didier ULg; Gangl, Monika et al

in Veterinary Research Communications (2007), 31(5), 591-601

Several breeds of draft horses suffer from degenerative digital osteoarthropathy, resulting in a reduced active lifespan. A group of 30 Ardenner horses was followed, in standardized conditions, from 15 to ... [more ▼]

Several breeds of draft horses suffer from degenerative digital osteoarthropathy, resulting in a reduced active lifespan. A group of 30 Ardenner horses was followed, in standardized conditions, from 15 to 28 months of age to detect the early manifestations of the disease. The severity of the disease was assessed according to a personal grading system including clinical and radiographic items. Coll 2-1, a peptide of the helical region of type II collagen, and its nitrated form (Coll 2-1 NO2) were assayed in blood plasma collected at 452 +/- 18 days, 504 +/- 20 days, 558 +/- 18 days, 613 +/- 19 days, 675 +/- 19 days, 752 +/- 21 days and 852 +/- 19 days of age. At the end of the follow-up period, 53.3% of Ardenner horses were affected by a degenerative digital osteoarthropathy. A significant effect (p < 0.05) of time, sex and pathology was observed for Coll 2-1 NO2. Variations of Coll 2-1 were not significant except for the time effect. The elevation of Coll 2-1 NO2 in the pathological group could indicate an inflammatory process during the growth of the affected horses, as nitration of tyrosine is mediated through reactive oxygen/nitrogen species and/or myeloperoxidase activity. Coll 2-1 NO2 appears to be an interesting early marker of cartilage degradation and oxidation in degenerative osteoarthropathy. [less ▲]

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See detailPlasma concentration of insulin-like growth factor I (IGF-I) in growing Ardenner horses suffering from juvenile digital degenerative osteoarthropathy
Lejeune, Jean-Philippe ULg; Franck, Thierry ULg; Gangl, Monika et al

in Veterinary Research Communications (2007), 31(2), 185-195

Degenerative osteoarthropathy resulting in a reduced active lifespan was observed in Ardenner horses. In the context of joint biology, insulin-like growth factor I (IGF-I) is a potential candidate to ... [more ▼]

Degenerative osteoarthropathy resulting in a reduced active lifespan was observed in Ardenner horses. In the context of joint biology, insulin-like growth factor I (IGF-I) is a potential candidate to affect the anabolism of cartilage matrix molecules. A group of 30 Ardenner horses reared under standardized conditions from weaning were evaluated periodically from 15 to 28 months of age to detect the early manifestations of the disease. At the end of this period, horses were classified in two pathological groups related to the degree of interphalangeal degenerative osteoarthropathy based on clinical and radiographic evaluations: healthy (46.7%) and pathological (53.3%) horses. Seven sequential blood samples were taken from each horse (during the evaluation period) to study the variation of IGF-I plasma concentration. We tested the variations of the IGF-I plasma concentration during growth, and the effect of sex and of pathological classes. Significant variations were observed during the research period, with a maximum value corresponding to spring and a minimum in autumn. A significant reduction of the IGF-I plasma concentration was also observed in the pathological horses (433.5 +/- 19.5 ng/ml) compared to the healthy horses (493.9 +/- 18.2 ng/ml). An alteration in the level of this growth factor could induce a disregulation of the mechanisms involved in the local control of joint and bone tissue development. [less ▲]

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See detailA type II-collagen derived peptide and its nitrated form as new markers of inflammation and cartilage degradation in equine osteochondral lesions.
Gangl, Monika; Deberg, Michelle ULg; Lejeune, Jean-Philippe ULg et al

in Research in Veterinary Science (2007), 82

Markers of cartilage breakdown enable studying the degradation of cartilage matrix in equine joint pathologies. This study was designed to determine the levels of Coll2-1, a peptide of the triple helix of ... [more ▼]

Markers of cartilage breakdown enable studying the degradation of cartilage matrix in equine joint pathologies. This study was designed to determine the levels of Coll2-1, a peptide of the triple helix of type II collagen, and Coll2-1NO(2), its nitrated form in the plasma of healthy horses (controls; n=37) and horses suffering from osteochondrosis (n=34). Clinical and arthroscopic scores were attributed reflecting the severity of lesions and were related to the plasma levels of Coll2-1 and Coll2-1NO(2). The median of Coll2-1 was significantly higher in the control group, whereas the mean of Coll2-1NO(2) showed significant elevation in the pathological group. However, the measurement means of scoring classes did not vary significantly. The markers were able to differentiate the group of horses suffering from osteochondrosis from the group of healthy horses. The elevation of Coll2-1NO(2) in the pathological group indicates an inflammation, mediated through reactive oxygen species and/or increased myeloperoxidase activity. [less ▲]

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See detailGastrointestinal prokinetics'efficiency and risk factors of development of postoperative ileus: clinical study.
Salciccia, Alexandra ULg; Péters, Fabrice; Gangl, Monika et al

Conference (2006, June 29)

Because of the lack of clinical data in the area, this clinical study was performed to evaluate gastrointestinal prokinetics’ efficiency. Material used includes 2 groups composed each one by 25 horses ... [more ▼]

Because of the lack of clinical data in the area, this clinical study was performed to evaluate gastrointestinal prokinetics’ efficiency. Material used includes 2 groups composed each one by 25 horses which underwent surgery for small intestinal lesions in the University of Liège between january 1997 and august 2005. The 2 groups were formed by a selection resulting in similar (or not significantly different) mean values for the age, gravity score, shock score, packed cell volume on admission in the clinic and length of resected intestine when an enterectomy was performed. Between the 2 groups, we searched also equal (or not significantly different) proportions of Belgian Warmblood, of females/males, of horses wich underwent an enterectomy, of horses which had a concomitant lesion of the large intestine and of horses wich needed 1 or more sedative α2 agonist drug during the postoperative period. One group was treated with gastrointestinal prokinetics (lidocaine, erythromycin, metoclopramide) systematically, whereas the other one not and the incidence and duration of postoperative ileus was evaluated. No significant difference in the incidence or the duration of postoperative ileus was found between the 2 groups. Because our results did not show any effect of prokinetics, a statistical analysis searched in these 50 horses the risk factors of postoperative ileus among the following parameters: breed, age, sex, gravity score, shock score, packed cell volume on admission in the clinic, protocol of induction of anaesthesia, duration of anaesthesia, performing an enterectomy and length of the resected intestine, concomitant lesion of the large intestine, and administration of sedative α2 agonists during the postoperative period. Only the Belgian warmblood breed and the administration of sedative α2 agonist drugs after the recovery from anaesthesia were significantly more important in the group where horses developed a postoperative ileus. Undoubdtedly, this study includes only 50 cases selected for the homogeneity of their parameters and not all the cases of small intestine surgery during the test period. In view of these results, it would be interesting performing this study again on a larger number of cases in a prospective manner. [less ▲]

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See detailPrognostic value of white blood cell drop in horses undergoing post-colic surgery intensive care.
Chiavaccini, Ludovica; Péters, Fabrice; Gangl, Monika et al

Conference (2006)

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See detailComment réaliser une immobilisation avec des support externes rigides ? Description de deux techniques
Gangl, Monika; Verwilghen, Denis ULg; Piccot-Crezollet, Cyrille et al

Poster (2006)

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See detailPancreatic damage observed in two horses euthanized for persistent paralytic ileus.
Grulke, Sigrid ULg; Deby, Ginette ULg; Gangl, Monika et al

Poster (2002, July)

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See detailPeritoneal trypsin level in equine acute abdominal disease.
Grulke, Sigrid ULg; Gueret, Patricia; Gangl, Monika et al

Conference (2002, July)

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See detailPlasma trypsin level increase in horses during post-operative period after colic surgery.
Grulke, Sigrid ULg; Gangl, Monika; Deby, Ginette ULg et al

Conference (2001, October)

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See detailRetrospective study of 206 cases of surgical intestinal pathologies in the horse : incidence, diagnosis, prognosis and complications.
Grulke, Sigrid ULg; Gangl, Monika; Caudron, Isabelle et al

in Annales de Médecine Vétérinaire (2000), 144

This retrospective study of 206 surgical colic cases shows the incidence of the different types of pathologies. The small intestine is concerned in 106 (51,5 %) cases with 102 (96 %) strangulation ... [more ▼]

This retrospective study of 206 surgical colic cases shows the incidence of the different types of pathologies. The small intestine is concerned in 106 (51,5 %) cases with 102 (96 %) strangulation obstructions. The remaining 100 cases (48,5 %) are large intestine obstructions with 45 (45 %) strangulation obstructions. The global survival rate is of 51,5 %, of 42,2 % for small intestine and of 61 % for large intestine. A gravity and a shock score permit to define the prognosis before the decision for surgery. The incidence of the postoperative complications is higher (55,2 %) and the time for recovery is significantly longer for small intestinal pathologies than for large intestine affections. Shock and paralytic ileus are the most frequent complications accounting for 65 % of post operative mortalities. The survival rates are significantly different according to gravity and shock score. The time of recovery is also significantly different in function of the shock score. These findings show the importance of rapid diagnosis of the acute abdominal disease in order to improve the outcome. [less ▲]

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See detailGravity Score and Shock Score as an Aid to dertemine the prognosis in Equine Surgical Colic Cases
Grulke, Sigrid ULg; Olle, Enrice; Detilleux, Johann ULg et al

in Veterinary Surgery : The Official Journal of the American College of Veterinary Surgeons (1999, July)

Detailed reference viewed: 27 (10 ULg)