References of "Gandar, Frederic"
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See detailDetection of Usutu virus in a bullfinch (Pyrrhula pyrrhula) and a great spotted woodpecker (Dendrocopos major) in north-west Europe
Garigliany, Mutien-Marie ULg; Marlier, Didier ULg; Tenner-Racz, Klara et al

in Veterinary Journal (2014), 199

In October 2012, a 3-year-old bullfinch (Pyrrhula pyrrhula) held in captivity for its entire lifespan and a wild adult great spotted woodpecker (Dendrocopos major), both with neurological signs, were ... [more ▼]

In October 2012, a 3-year-old bullfinch (Pyrrhula pyrrhula) held in captivity for its entire lifespan and a wild adult great spotted woodpecker (Dendrocopos major), both with neurological signs, were found 4 km from each other and 5 days apart in the Meuse Valley, Belgium. Non-suppurative encephalitis and mild degeneration and necrosis were identified in the brain and cerebellum, and Usutu virus antigen and RNA were detected by immunohistochemistry and real-time reverse transcriptase PCR, respectively. The two cases reported here represent the most western distribution of clinical disease in birds due to Usutu virus. [less ▲]

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See detailDetection of Usutu virus in a bullfinch (Pyrrhula pyrrhula) and a great spotted woodpecker (Dendrocopos major) in north-west Europe
Garigliany, Mutien-Marie ULg; Marlier, Didier ULg; Tenner-Racz, Klara et al

in Veterinary Journal (2014), 199

In October 2012, a 3-year-old bullfinch (Pyrrhula pyrrhula) held in captivity for its entire lifespan and a wild adult great spotted woodpecker (Dendrocopos major), both with neurological signs, were ... [more ▼]

In October 2012, a 3-year-old bullfinch (Pyrrhula pyrrhula) held in captivity for its entire lifespan and a wild adult great spotted woodpecker (Dendrocopos major), both with neurological signs, were found 4 km from each other and 5 days apart in the Meuse Valley, Belgium. Non-suppurative encephalitis and mild degeneration and necrosis were identified in the brain and cerebellum, and Usutu virus antigen and RNA were detected by immunohistochemistry and real-time reverse transcriptase PCR, respectively. The two cases reported here represent the most western distribution of clinical disease in birds due to Usutu virus. [less ▲]

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See detailIN-VITRO EVALUATION OF A-5021 ANTI-VIRAL ACTIVITY AGAINST TESTUDINID HERPESVIRUS 3 AND INITIAL PHARMACOKINETIC STUDY IN HERMANN'S TORTOISE (Testudo hermanni)
Gandar, Frederic ULg; Vrancken, Robert; Diez, Marianne ULg et al

Conference (2013, April 23)

Testudinid herpesvirus infections in tortoises belonging to the Testudinidae family are well known for decades, but their pathogenesis remains poorly understood and treatments are often empirical. This ... [more ▼]

Testudinid herpesvirus infections in tortoises belonging to the Testudinidae family are well known for decades, but their pathogenesis remains poorly understood and treatments are often empirical. This study describes the in vitro evaluation of selected anti-herpesvirus compounds against Testudinid Herpesvirus 3 (THV-3). A-5021, a compound with known broad-spectrum anti-herpetic activity, showed to be 9 times more potent than acyclovir, with an EC50 of 13.2 µM and inducing a complete inhibition of viral replication at 37.7 µM. Initial pharmacokinetic parameters were determined after a single sub-cutaneous administration of 5 and 10 mg/kg in Hermann’s tortoises (Testudo hermanni, n=3). Blood samples were collected at different time points and plasma concentrations of A-5021 were determined. No adverse effects were clinically observed and plasma concentrations remained above the EC50 for 2.8 and 4.2 h after administration of 5 and 10 mg/kg, respectively. These preliminary data provide a basis for further proof-of-concept studies for a potential prophylactic or therapeutic treatment of THV-3 infection in tortoises [less ▲]

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See detailAdenoid Hepatocellular Carcinoma Accompanied by Uncharacterized Eosinophilic Intracytoplasmic Inclusions in a Green Iguana (Iguana iguana)
Schilliger, Lionel; Selleri, Paolo; Gandar, Frederic ULg et al

in Journal of Herpetological Medicine and Surgery (2012), 22(3-4), 70-75

An adult, 2.9 kg, 4-year-old female green iguana, Iguana iguana, was examined for anorexia, weight loss, and lethargy. Physical examination revealed a dull integument, minimal pelvic and tailbase adipose ... [more ▼]

An adult, 2.9 kg, 4-year-old female green iguana, Iguana iguana, was examined for anorexia, weight loss, and lethargy. Physical examination revealed a dull integument, minimal pelvic and tailbase adipose deposits, and a distended coelom. Bilateral renal enlargement was identified on intracloacal digital palpation. Complete blood count and serum biochemistry results indicated hepatic and renal disease. Radiographs and ultrasound revealed severe liver enlargement and ascites. Exploratory coeliotomy revealed a massive and diffusely enlarged liver with rounded margins and a smooth capsular surface, indicative of an infiltrative process. Due to poor prognosis, the owner requested that the animal be euthanized. A diagnosis of acinar hepatocellular carcinoma was made on histopathological evaluation of liver tissue collected after euthanasia. Eosinophilic intracytoplasmic inclusion bodies, surrounded by clear halos, were seen in a few neoplastic cells. Several malignant hepatic tumors have been previously reported in reptiles; however, this case report documents the first reptilian adenoid hepatocellular carcinoma associated with intracytoplasmic eosinophilic inclusions in neoplastic hepatocytes. [less ▲]

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See detailPneumonia with Aeromonas sobria in a Carpet Python
Gandar, Frederic ULg; Szalo, Ioan Mihai ULg; Marlier, Didier ULg

Conference (2011, August 11)

Aeromonas sobria was isolated and identified upon post-mortem examination from the respiratory tract and the blood of a carpet python (Morelia spilota variegata). The snake was referred to the Faculty of ... [more ▼]

Aeromonas sobria was isolated and identified upon post-mortem examination from the respiratory tract and the blood of a carpet python (Morelia spilota variegata). The snake was referred to the Faculty of Veterinary Medicine of Liège for necropsy, just the day after it suddenly died without previous clinical sign. Lung and liver biopsies were performed and fixed in neutral buffered 10% formalin and paraffin embedded. Blood samples were collected via cardiocentesis, and air sac abscesses were cultured. Bacterial strains were identified as Aeromonas sobria by 16S rDNA sequencing. Based on histological and bacterial examinations, the death of this snake was attributed to a septicemia, following an acute primary, or secondary exudative pneumonia. Aeromonas sp. is established as a potential pathogen in reptiles. Among this genus, Aeromonas hydrophila is the most frequently isolated. A. sobria has been reported as a primary pathogen in farmed perch (Perca fluviatilis) and humans. Conversely, few data are available concerning the pathogenicity of A. sobria in reptiles. Other non-bacterial agents (virus, fungus, endoparasites) or predisposing factors (such as obesity) can also be responsible for respiratory tract disease in snakes . Unfortunately, in the current case, virological investigations were not performed. [less ▲]

Detailed reference viewed: 106 (15 ULg)