References of "GERARD, Pascale"
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See detailEffects of light deprivation on visual evoked potentials in migraine without aura.
Coppola, Gianluca; Cremers, Julien ULg; GERARD, Pascale ULg et al

in BMC Neurology (2011), 11

BACKGROUND: The mechanisms underlying the interictal habituation deficit of cortical visual evoked potentials (VEP) in migraine are not well understood. Abnormal long-term functional plasticity of the ... [more ▼]

BACKGROUND: The mechanisms underlying the interictal habituation deficit of cortical visual evoked potentials (VEP) in migraine are not well understood. Abnormal long-term functional plasticity of the visual cortex may play a role and it can be assessed experimentally by light deprivation (LD). METHODS: We have compared the effects of LD on VEP in migraine patients without aura between attacks (MO, n = 17) and in healthy volunteers (HV, n = 17). Six sequential blocks of 100 averaged VEP at 3.1 Hz were recorded before and after 1 hour of LD. We measured VEP P100 amplitude of the 1st block of 100 sweeps and its change over 5 sequential blocks of 100 responses. RESULTS: In HV, the consequence of LD was a reduction of 1st block VEP amplitude and of the normal habituation pattern. By contrast, in MO patients, the interictal habituation deficit was not significantly modified, although 1st block VEP amplitude, already lower than in HV before LD, further decreased after LD. CONCLUSIONS: Light deprivation is thought to decrease both excitatory and subsequent inhibitory processes in visual cortex, which is in line with our findings in healthy volunteers. The VEP results in migraine patients suggest that early excitation was adequately suppressed, but not the inhibitory mechanisms occurring during long term stimulation and habituation. Accordingly, deficient intracortical inhibition is unlikely to be a primary factor in migraine pathophysiology and the habituation deficit. [less ▲]

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See detailInterictal abnormalities of gamma band activity in visual evoked responses in migraine: an indication of thalamocortical dysrhythmia?
Coppola, G.; Ambrosini, Anna; Di Clemente, L. et al

in Cephalalgia : An International Journal of Headache (2007), 27(12), 1360-1367

Between attacks, migraineurs lack habituation in standard visual evoked potentials (VEPs). Visual stimuli also evoke high-frequency oscillations in the gamma band range (GBOs, 20-35 Hz) assumed to be ... [more ▼]

Between attacks, migraineurs lack habituation in standard visual evoked potentials (VEPs). Visual stimuli also evoke high-frequency oscillations in the gamma band range (GBOs, 20-35 Hz) assumed to be generated both at subcortical (early GBOs) and cortical levels (late GBOs). The consecutive peaks of GBOs were analysed regarding amplitude and habituation in six successive blocks of 100 averaged pattern reversal (PR)-VEPs in healthy volunteers and interictally in migraine with (MA) or without aura patients. Amplitude of the two early GBO components in the first PR-VEP block was significantly increased in MA patients. There was a significant habituation deficit of the late GBO peaks in migraineurs. The increased amplitude of early GBOs could be related to the increased interictal visual discomfort reported by patients. We hypothesize that the hypofunctioning serotonergic pathways may cause, in line with the thalamocortical dysrhythmia theory, a functional disconnection of the thalamus leading to decreased intracortical lateral inhibition, which can induce dishabituation. [less ▲]

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See detailSearch for correlations between genotypes and electrophysiological patterns in migraine: the MTHFR C677T polymorphism and visual evoked potentials
Magis, Delphine ULg; Allena, M.; Coppola, G. et al

in Cephalalgia : An International Journal of Headache (2007), 27(10), 1142-1149

Interictally, migraineurs have on average a reduction in habituation of pattern-reversal visual evoked potentials (PR-VEP) and in mitochondrial energy reserve. 5,10-Methylenetetrahydrofolate reductase ... [more ▼]

Interictally, migraineurs have on average a reduction in habituation of pattern-reversal visual evoked potentials (PR-VEP) and in mitochondrial energy reserve. 5,10-Methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism and its C677T polymorphism may be more prevalent in migraine. The aim of this study was to search in migraineurs for a correlation between the MTHFR C677T polymorphism and the PR-VEP profile. PR-VEP were recorded in 52 genotyped migraine patients: 40 female, 24 without (MoA), 28 with aura (MA). Among them 21 had a normal genotype (CC), 18 were heterozygous (CT) and 13 homozygous (TT) for the MTHFR C677T polymorphism. Mean PR-VEP N1-P1 amplitude was significantly lower in CT compared with CC, and tended to be lower in TT with increasing age. The habituation deficit was significantly greater in CC compared with TT subjects. The correlation between the cortical preactivation level, as reflected by the VEP amplitude in the first block of averages, and habituation was stronger in CC than in CT or TT. The MTHFR C677T polymorphism could thus have an ambiguous role in migraine. On one hand, the better VEP habituation which is associated with its homozygosity, and possibly mediated by homocysteine derivatives increasing serotoninergic transmission, may protect the brain against overstimulation. On the other hand, MTHFR C677T homozygosity is linked to a reduction of grand average VEP amplitude with illness duration, which has been attributed to brain damage. [less ▲]

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See detailInterictal cognition in migraineurs: a study correlating psychometric and neurophysiological tests
Magis, Delphine ULg; Coppola, G.; Di Clemente, L. et al

in Cephalalgia : An International Journal of Headache (2007, June), 27(6), 714

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See detailDegré d'atteinte nerveuse périphérique dans la SLA, la SLP et la maladie de Kennedy
WANG, François-Charles ULg; Le Forestier, Nadine; GERARD, Pascale ULg et al

in Neurophysiologie Clinique = Clinical Neurophysiology (2006)

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See detailValeur pronostique de la TASPM dans la SLA
WANG, François-Charles ULg; GERARD, Pascale ULg; MAERTENS DE NOORDHOUT, Alain ULg

in Neurophysiologie Clinique = Clinical Neurophysiology (2006)

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See detailNovel diagnostic approach to carpal tunnel syndrome
WANG, François-Charles ULg; GERARD, Pascale ULg; ISERENTANT, Cynthia ULg

Scientific conference (2005, December)

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See detailLack of habituation of visual evoked gamma band oscillations in migraine patients between attacks
Coppola, G.; Ambrosini, A.; Di Clemente, L. et al

in Cephalalgia : An International Journal of Headache (2005, October), 25(10), 885

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See detailEffects of nitroglycerin on the nociception specific blink reflex
Di Clemente, Laura; Magis, Delphine ULg; Coppola, Gianluca et al

in Cephalalgia : An International Journal of Headache (2005, October), 25(10), 888

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See detailThe syndrome of transient headache with neurological deficits and CSF lymphocytosis (HaNDL): electrophysiological findings suggesting a migrainous pathophysiology
Fumal, Arnaud ULg; Vandenheede, Michel; Coppola, Giunluca et al

in Cephalalgia : An International Journal of Headache (2005), 25(9), 754-758

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See detailPROGNOSTIC VALUE OF AMPS METHOD IN ALS PATIENTS
WANG, François-Charles ULg; GERARD, Pascale ULg; BOUQUIAUX, Olivier ULg et al

in Amyotrophic Lateral Sclerosis & Other Motor Neuron Disorders (2005)

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See detailMOTOR UNIT INVOLVEMENT IN PLS, ALS AND KENNEDY’S DISEASE
WANG, François-Charles ULg; Le Forestier, Nadine; GERARD, Pascale ULg et al

in Amyotrophic Lateral Sclerosis & Other Motor Neuron Disorders (2005)

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See detailMOTOR UNIT INVOLVEMENT IN PLS, ALS AND KENNEDY’S DISEASE
WANG, François-Charles ULg; Le Forestier, Nadine; GERARD, Pascale ULg et al

Poster (2005)

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See detailAnalyse critique des techniques d'estimation du nombre d'unites motrices.
Wang, François-Charles ULg; Gerard, Pascale ULg; Bouquiaux, Olivier ULg

in Revue Médicale de Liège (2004), 59 Suppl 1

It is now 30 years since the first motor unit number estimation (MUNE) technique was introduced by Allan McComas as a way of providing an objective, sensitive and reproducible means of measuring the ... [more ▼]

It is now 30 years since the first motor unit number estimation (MUNE) technique was introduced by Allan McComas as a way of providing an objective, sensitive and reproducible means of measuring the number of motor axons in living human muscle or muscle group. MUNE techniques have substantially evolved over the past decade and have been applied, with increasing frequency, to the study of age effects on motoneurone population and muscle denervating disorders such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy, poliomyelitis and different types of inherited and acquired peripheral neuropathies. In the future, one of the most important topics involving MUNE, will probably be its use in monitoring the progress of ALS patients undergoing experimental drug trials. However, among incremental, multiple point stimulation, spike-triggered averaging, F-wave analysis and statistical methods, there is no consensus about the best MUNE method. There is only a general feeling that some techniques are more valid than others. For this reason, in the present review, brief descriptions of the distinct MUNE methods are presented. In the second part of the paper, advantages and limitations (alternation, sampling errors, temporal registration etc...) of the most commonly employed procedures are considered. [less ▲]

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See detailMUNE in the last 30 years: what can we expect of it in practice?
WANG, François-Charles ULg; GERARD, Pascale ULg; BOUQUIAUX, Olivier ULg

in Correspondances en Nerf & Muscle (2004)

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See detailPost-stroke reorganization of hand motor area : a 1-year prospective follow-up with focal transcranial magnetic stimulation
DELVAUX, Valérie ULg; Alagona, Giovanna; GERARD, Pascale ULg et al

in Clinical Neurophysiology (2003), 114(Issue 4), 1217-1225

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See detailSingle motor axon conduction velocities of human upper and lower limb motor units. A study with transcranial electrical stimulation
Dalpozzo, Francesca; GERARD, Pascale ULg; De Pasqua, Victor ULg et al

in Clinical Neurophysiology (2002), 113(2), 284-291

OBJECTIVES: To calculate conduction velocities (CV) of single motor axons innervating hand, forearm and leg muscles, weak anodal electrical transcranial stimuli were used and single motor unit potentials ... [more ▼]

OBJECTIVES: To calculate conduction velocities (CV) of single motor axons innervating hand, forearm and leg muscles, weak anodal electrical transcranial stimuli were used and single motor unit potentials were recorded in 17 normal subjects. METHODS: The central motor conduction time and neuromuscular transmission delay were subtracted from the latency of unit response to cortical stimulation and single motor axon CV were calculated. RESULTS: In extensor indicis proprius (EIP) units, CV ranged from 30.3 to 76.1m/s (mean: 51.3 +/- 7.1m/s, 139 units). In first dorsal interosseous (FDI), they ranged from 45.1 to 66.2m/s (mean: 54.6 +/- 2.6m/s, 88 units). In tibialis anterior (TA), velocities ranged from 27.8 to 55.9m/s (mean: 41.3 +/- 7.5m/s, 123 units). In FDI units, velocities were compared with those obtained with the F-wave method (range: 50.3-64.5m/s, mean: 58.1 +/- 2.0m/s). CONCLUSIONS: Compared with previously published values, the present method gives better access to slow-conducting units, first recruited by transcranial stimulation and voluntary effort. The spectrum of individual CV was much broader for EIP and TA than for FDI. A linear decline of maximal CV with age was observed, while minimal CV were not affected, suggesting that aging causes a selective loss of the fastest-conducting units. [less ▲]

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