  Recommandations pour le choix et l'harmonisation des techniques de dosage de la créatinine; ; et al in Annales de Biologie Clinique (2011), 69(1), 9-16 En 2010, un groupe de travail mixte constitué de la Société française de biologie clinique (SFBC) et de la Société de nephrologie (SN) a formulé les propositions suivantes afin de réactualiser les ... [more ▼] En 2010, un groupe de travail mixte constitué de la Société française de biologie clinique (SFBC) et de la Société de nephrologie (SN) a formulé les propositions suivantes afin de réactualiser les recommanadations pour le dosage de la créatinine plasmatique. [less ▲] Detailed reference viewed: 147 (1 ULg)A multicentric evaluation of IDMS-traceable creatinine enzymatic assays; DELANAYE, Pierre  ; et alin Clinica Chimica Acta (2011), 412 Chronic kidney disease definition is based on glomerular filtration rate (GFR) estimations which are derived from creatinine-based equations. The accuracy of GFR estimation is thus largely dependent of ... [more ▼] Chronic kidney disease definition is based on glomerular filtration rate (GFR) estimations which are derived from creatinine-based equations. The accuracy of GFR estimation is thus largely dependent of those of serum creatinine assays. International recommendations highlight the need for traceable creatinine assays. The French Society of Clinical Biochemistry conducted a study for measuring accuracy of creatinine enzymatic methods. This evaluation involved 25 clinical laboratories. Creatinine was measured in serum pools ranging from 35.9±0.9 μmol/L to 174.5±3.1 μmol/L (IDMS determination) using 12 creatinine enzymatic methods. For all creatinine values greater than 74.4±1.4 μmol/L, the bias and imprecision did not exceed 5% and 5.9%, respectively. For the lowest value (35.9±0.9 μmol/L), the bias ranged from −1.8 to 9.9% (with one exception). At this level, the imprecision ranged from 1.9 to 7.8%. The true performances of the assays (couples of bias and relative standard deviation), were evaluated using Monte-Carlo simulations. Most of the assays fall within the maximum Total Error of 12% at all concentrations. This study demonstrates substantial improvements in the calibration, traceability and precision of the enzymatic methods, reaching the NKDEP recommendations. Moreover, most of these assays allowed accurate creatinine measurements for creatinine levels lower than 40 μmol/L. [less ▲] Detailed reference viewed: 27 (2 ULg)Cystatin C: current position and future prospects.; Delanaye, Pierre ; et alin Clinical Chemistry & Laboratory Medicine (2008), 46(12), 1664-1686 Abstract Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal function that could replace creatinine. Indeed, the concentration of cystatin C is mainly determined by ... [more ▼] Abstract Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal function that could replace creatinine. Indeed, the concentration of cystatin C is mainly determined by glomerular filtration and is particularly of interest in clinical settings where the relationship between creatinine production and muscle mass impairs the clinical performance of creatinine. Since the last decade, numerous studies have evaluated its potential use in measuring renal function in various populations. More recently, other potential developments for its clinical use have emerged. This review summarises current knowledge about the physiology of cystatin C and about its use as a renal marker, either alone or in equations developed to estimate the glomerular filtration rate. This paper also reviews recent data about the other applications of cystatin C, particularly in cardiology, oncology and clinical pharmacology. Clin Chem Lab Med 2008;46:1664-86. [less ▲] Detailed reference viewed: 63 (3 ULg)Reproducibility of GFR measured by chromium-51-EDTA and iohexol.Delanaye, Pierre ; Cavalier, Etienne ; et alin Nephrology Dialysis Transplantation (2008), 23(12), 4077-84078 Detailed reference viewed: 18 (2 ULg)Cystatine C: point d'etape et perspectives.; Delanaye, Pierre ; et alin Annales de Biologie Clinique (2008), 66(3), 301-23 Cystatin C is a low molecular weight-protein, which may replace creatinine for the evaluation of renal function, particularly in the clinical settings where the relationship between creatinine production ... [more ▼] Cystatin C is a low molecular weight-protein, which may replace creatinine for the evaluation of renal function, particularly in the clinical settings where the relationship between creatinine production and muscular mass impairs the clinical performance of creatinine. This paper intends to summarize the current knowledge about the physiology of cystatin C and about its use as a renal marker, alone or within formulas developed to estimate the glomerular filtration rate. Moreover, this paper reviews the recent data about potential other applications of cystatin C, especially in cardiology, in oncology and in clinical pharmacology. [less ▲] Detailed reference viewed: 51 (1 ULg)Evaluation de la fonction renale: une actualisation.; Delanaye, Pierre ; et alin Annales de Biologie Clinique (2008), 66(3), 269-75 During the last years, GFR estimation has received substantial attention with a focus on comparing results of new formulas with GFR measurements, and standardization of creatinine assays. Calibration of ... [more ▼] During the last years, GFR estimation has received substantial attention with a focus on comparing results of new formulas with GFR measurements, and standardization of creatinine assays. Calibration of creatinine should improve performances. However, frequently used equations have lower precision in high GFR populations. This is the reason why a continuous effort in improving predicting equations is still needed. The use of calibrated creatinine, the onset of new GFR markers such as cystatin C, and pooling data across many study populations are underway to develop better prediction. [less ▲] Detailed reference viewed: 108 (2 ULg)Renal extraction of cystatin CDelanaye, Pierre ; Cavalier, Etienne ; Chapelle, Jean-Paul et alin Nephrology Dialysis Transplantation (2006), 21(11), 3333-3333 Detailed reference viewed: 18 (1 ULg) |
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