References of "Frederich, Michel"
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See detailFood Compounds from Meadow Grasshoppers
Paul, Aman ULg; Frederich, Michel ULg; Uyttenbroeck, Roel ULg et al

Poster (2015, March 15)

Eating insects as food, particularly grasshopper is practiced in many cultures throughout the world. Meadow grasshopper (Chorthippus parallelus) is commonly found in Europe and some part of Asia. It is ... [more ▼]

Eating insects as food, particularly grasshopper is practiced in many cultures throughout the world. Meadow grasshopper (Chorthippus parallelus) is commonly found in Europe and some part of Asia. It is already known that grasshoppers of Chorthippus species are consumed as food in countries such as Thailand. With the aim of evaluating the nutritional potential of this insect species the proximate nutritional composition of grasshoppers caught from the local fields was realized. Besides this, the fatty acid profile of extracted lipids, amino acid profile and mineral composition of the insect was also revealed. Results suggest that meadow grasshopper is an excellent source of protein and essential amino acids. Lipids extracted from the grasshopper have an interesting fatty acid composition. Also the grasshopper contains some minerals that are important for body. With such protein content, amino acid profile, fatty acid profile of the lipids and mineral content this grasshopper species could present an interesting alternate to conventional protein sources. [less ▲]

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See detailLes plantes qui nous soignent : de la tradition à la médecine moderne
Frederich, Michel ULg

Scientific conference (2015, February 23)

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See detailMultiplicity editing in long-range heteronuclear correlation NMR experiments: Application to natural products
Sauri, Josep; Sistare, E.; Frederich, Michel ULg et al

Poster (2015, February)

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See detailIdentification of Cytotoxic and Antioxidant Compounds from Allium gramineum Flowers
Mskhiladze, Lasha; Chincharadze, David; Tits, Monique ULg et al

in International Journal of Pharmaceutical Sciences and Drug Research (2015), 7

The present study evaluates the in vitro anticancer, antiplasmodial and antioxidant activity of the ethanolic crude extract from the flowers of Allium gramineum growing in Georgia and of one flavonol and ... [more ▼]

The present study evaluates the in vitro anticancer, antiplasmodial and antioxidant activity of the ethanolic crude extract from the flowers of Allium gramineum growing in Georgia and of one flavonol and two steroidal glycosides which were isolated from this plant. The flowers were extracted with ethanol and this total extract was subjected to successive bioguided fractionations to provide glycosides 1-3. Their structures were elucidated on the basis of NMR and ESI-MS spectrometric data in comparison with the existing literature and have been identified as: isorhamnetin-3-O-β-D-glucopyranoside (1), diosgenin-3-O-α-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (Prosapogenin A of dioscin) (2), diosgenin-3-O-α-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)-]-β-D-glucopyranoside (Deltonine) (3). The ethanolic extract has been shown to strongly inhibit the growth of breast adenocarcinoma cell lines, with an IC50 of 4.5 ± 0.7μg/mL for MDAMB-231 and 4.8 ± 0.9μg/mL for MCF-7 cells. The cytotoxic activity was related to 2 and 3 which exhibited potent cytotoxicity, with an IC50 of ± 3μM. Concerning antiplasmodial activities, only weak activities were observed using the ethanolic extract and the two saponins. The flavonoid was almost inactive. Finally, the radical-scavenging activity of the ethanolic extract was tested in presence of ABTS·+ solution. A decrease of the absorbance intensity was observed, with an IC50 value of 22.1 ± 0.6μg/mLwhile trolox, used as Standard drug, showed a pronounced activity (IC50 = 12.7±0.5μM). The glycoside 1 showed the lowest IC50 value of 20.1 ± 0.8μM while both 2 and 3 exhibited very weak radical scavenging activity. [less ▲]

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See detailThe emergence of metabolomics as a key discipline in the drug discovery process
Fillet, Marianne ULg; Frederich, Michel ULg

in Drug Discovery Today: Technologies (2015)

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See detailA new ent-clerodane diterpenoid from Crassocephalum bauchiense Huch. (Asteraceae).
Tchinda, Alembert T.; Mouokeu, Simplice R.; Ngono, Rosalie A. N. et al

in Natural product research (2015)

A phytochemical investigation of the whole plant of Crassocephalum bauchiense Huch. resulted in the isolation of a new clerodane diterpenoid, ent-2beta,18,19-trihydroxycleroda-3,13-dien-16,15-olide (1 ... [more ▼]

A phytochemical investigation of the whole plant of Crassocephalum bauchiense Huch. resulted in the isolation of a new clerodane diterpenoid, ent-2beta,18,19-trihydroxycleroda-3,13-dien-16,15-olide (1), together with two known flavonoids 3',5-dihydroxy-4',5',6,7,8-pentamethoxyflavone (2) and 4',5-dihydroxy-3',5',6,7,8-pentamethoxyflavone (3). The compounds were tested against the chloroquine-sensitive 3D7 strain of Plasmodium falciparum. Compound 2 showed weak activity (IC50 = 10.1 g/mL) whilst compounds 1 and 3 were inactive. The structures of the compounds were elucidated by using detailed spectral analyses, especially 1H and 13C NMR, 1H-1H COSY, NOESY, HMBC and HR-ESI-MS. [less ▲]

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See detailLes nouveaux outils de diagnostic et de pronostic de la myopathie atypique
Habyarimana, Jean ULg; BOEMER, François ULg; Amory, Hélène ULg et al

in Proceeding de la 41ème Journée de la Recherche équine (2015)

In equines, ingestion of hypoglycin A, a toxin produced in the seeds (samaras) of sycamore maple (Acer pseudoplatanus) tree alters the energetic metabolism of muscle cells and results in atypical myopathy ... [more ▼]

In equines, ingestion of hypoglycin A, a toxin produced in the seeds (samaras) of sycamore maple (Acer pseudoplatanus) tree alters the energetic metabolism of muscle cells and results in atypical myopathy (AM). This alterations leads to a characteristic biochemical profile of acylcarnitines (AC) that enables to confirm the diagnosis of AM. This study aims at validating a methodology for the dosage of hypoglycin A in vegetal extracts but also in blood. In addition, the biochemical profile in AC has been determined in AM cases (5 survivors and 13 deceased) and in 5 horses suffering from exercise-induced myopathy. The AC profiles of these horses have been compared to the one of healthy horses (n = 35). This study showed that hypoglycin A was present in seeds and spring seedlings of sycamore and also in blood of AM cases horses. In addition, the establishment of AC profile contributes to the diagnostic and helps to assess the prognosis of AM cases. [less ▲]

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See detailTwo new aromadendrane sesquiterpenes from the stem bark of Alafia multiflora
Tchinda Tiabou, Alembert ULg; Tsala, David E.; Nnanga, Nga et al

in Natural Product Communications (2014), 9(12), 1673-1675

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See detailINVESTIGATION OF TWO IMPROVED TRADITIONAL MEDICINES: DEVELOPMENT AND VALIDATION OF A LC-UV METHOD FOR THE DOSAGE OF A TRACER COMPOUND
Tshisekedi Tshibangu, Pascal; Kalenda Dibungi, Pascal; Rozet, Eric ULg et al

Poster (2014, June)

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See detailMealworms: Alternate Source of Lipids
Danthine, Sabine ULg; Blecker, Christophe ULg; Paul, Aman ULg et al

Scientific conference (2014, May 16)

The aim of present study was to determine the physicochemical properties of the oil obtained from Tenebrio molitor larvae (mealworms) and explore its potential as edible oil. Five batches of Tenebrio ... [more ▼]

The aim of present study was to determine the physicochemical properties of the oil obtained from Tenebrio molitor larvae (mealworms) and explore its potential as edible oil. Five batches of Tenebrio molitor larvae were investigated for their lipid content and physiochemical properties. Three batches were reared in lab (3 different productions) and two were purchased from a local supplier. The lipids were extracted using a cold extraction technique employing 2:1 ratio chloroform/methanol as solvent. The fatty acid profile was determined using gas chromatography and triacylglycerol profile using HPLC. The thermal properties of the lipid extracts were also analyzed using differential scanning calorimetry. All the samples contained high amount of unsaturated fatty acids. The chemical composition and the thermal properties of the samples varied with the source. With this quantity and quality of lipid content, mealworms offer potential as an important source of edible lipids. [less ▲]

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See detailBelgian Grasshoppers: A Nutritious Food Source
Paul, Aman ULg; Frederich, Michel ULg; Blecker, Christophe ULg et al

Poster (2014, May 14)

Rapid urbanization and rising economies are creating shifts in the composition of global food demand, so it is necessary to explore new sources of food with better nutritional profile. Among the ... [more ▼]

Rapid urbanization and rising economies are creating shifts in the composition of global food demand, so it is necessary to explore new sources of food with better nutritional profile. Among the alternative food that exists are the grasshoppers, about 80 species of which are consumed worldwide. Grasshoppers are not only rich source of proteins and lipids but also some important minor component like vitamins and minerals. Edible species of grasshopper in Belgium were identified and attempts were made for the lab rearing of meadow grasshopper (Chorthippus parallelus). The lipids as well as protein contents of meadow grasshopper (Chorthippus parallelus) & long winged conehead (Conocephalus discolor) were investigated. The fatty acid compositions of these two species were determined by gas chromatography. Some of the physicochemical properties of the lipids extracted were also analyzed. These two grasshopper species could be really nutritious source of food. [less ▲]

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See detailLocusts and Grasshoppers: Future Foods?
Paul, Aman ULg; Frederich, Michel ULg; Uyttenbroeck, Roel ULg et al

Scientific conference (2014, May 08)

Consuming locusts and grasshoppers as food is not a new concept, because some people have been doing it for a long time and there are many references in the religious literature to support this. About 80 ... [more ▼]

Consuming locusts and grasshoppers as food is not a new concept, because some people have been doing it for a long time and there are many references in the religious literature to support this. About 80 locust and grasshopper species are consumed worldwide, and the large majority of grasshopper species are edible. From the nutritional point of view they are an excellent source of proteins, lipids and other minor components like vitamins and minerals. They are an excellent source of amino acids and their lipids contain a large majority of unsaturated fatty acids. Environmentalists have supported human consumption of grasshoppers owing to the facts that they usually appear as pests. Using them as food could help reduce their population and result in limited application of harmful pesticides. Their production usually generates lesser amount of greenhouse gases & ammonia; a lower amount of water is required for their production in comparison to conventional proteins sources. Some species of grasshoppers usually feed on dead organic matter, this reduces the environmental load. In the developing world, catching of grasshoppers and selling them for human consumption has played a key role in improving the livelihood of women and underprivileged children. Eating grasshopper and locust is not a very common practice in temperate areas. However it is a very common practice in the tropical areas of world because of the higher density, bigger size of the insect and yearlong availability in such areas. To encourage their consumption in temperate areas, it is now necessary to perform accurate research regarding food safety (minor components, toxicity, allergens,…) but also to develop value added products to make it easier for people to adapt with entomophagy. Furthermore we have to develop methods for commercial production and organize awareness campaigns to explain about the nutritional and other benefits related to locust & grasshopper consumption as food to people. [less ▲]

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See detailNetamines H-N, Tricyclic Alkaloids from the Marine Sponge Biemna laboutei and Their Antimalarial Activity.
Gros, Emmanuelle; Al-Mourabit, Ali; Martin, Marie-Therese et al

in Journal of natural products (2014), 77(4), 818-23

Chemical examination of the CH2Cl2-MeOH (1:1) extract of the Madagascar sponge Biemna laboutei resulted in the isolation of seven new tricyclic alkaloids, netamines H-N (1-7), along with the known ... [more ▼]

Chemical examination of the CH2Cl2-MeOH (1:1) extract of the Madagascar sponge Biemna laboutei resulted in the isolation of seven new tricyclic alkaloids, netamines H-N (1-7), along with the known netamine G and mirabilins A, C, and F. Their structures were elucidated by interpretation of 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their cytotoxicity against KB cells and their antiplasmodial activity. Netamine M (6) was found to be cytotoxic, with an IC50 value in the micromolar range, and netamine K (4) exhibited activity against Plasmodium falciparum with an IC50 value of 2.4 muM. [less ▲]

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See detailChemical analyses of the seeds from Prunella vulgaris: A chemotaxonomic approach
Paul, Aman ULg; Frederich, Michel ULg; Cieckiewicz, Ewa ULg et al

Poster (2014, April)

Common self-heal (Prunella vulgaris) plants are traditionally sown along the border of crops to enhance the biodiversity. Besides enhancing the biodiversity, they can also be a source of interesting ... [more ▼]

Common self-heal (Prunella vulgaris) plants are traditionally sown along the border of crops to enhance the biodiversity. Besides enhancing the biodiversity, they can also be a source of interesting compounds which could be important for food, pharmaceutical and cosmetic industries. The seeds of Common Yarrow were investigated for proteins, fatty acid compositions and polyphenolic compounds. The protein content was analyzed according to Dumas method, the extraction of oil was done using a cold extraction technique employing 2:1 chloroform/methanol as solvent, the fatty acid composition was determined using the gas chromatography and the amount of polyphenolic compounds were estimated using the method as described in European Pharmacopoeia, 8th edition. Common self-heal seeds can be of great commercial importance. [less ▲]

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See detailSome Interesting Sources of Plant Seed Oil
Paul, Aman ULg; Danthine, Sabine ULg; Blecker, Christophe ULg et al

Poster (2014, March 05)

There is a growing realization worldwide that biodiversity is fundamental to agricultural production and food security, as well as a valuable ingredient of environmental conservation. Flowering strips ... [more ▼]

There is a growing realization worldwide that biodiversity is fundamental to agricultural production and food security, as well as a valuable ingredient of environmental conservation. Flowering strips around the border of the crops serves as an important function to improve the biodiversity, besides this they play a major role in the ruminant nutrition and serve as a source of numerous beneficial compounds. It is well known that seeds store their food reserves for next generation mainly in the form of lipids; some of the seeds from these flowering strips could be an interesting source of lipids. These seed oils could play important role in food, pharmaceutical, cosmetics and other industries. The extraction of seed oil from four such plant species in Belgium namely Oregano (Origanum vulgare), Yellow Bedstraw (Galium verum), Common Self-heal (Prunella vulgaris) & Purple loosestrife (Lythrum salicaria) was carried out. Extraction was done by a cold extraction technique using chloroform/methanol in 2:1 ratio as solvent. Amount of oil extracted from Oregano, Yellow Bedstraw, Common Self-heal and Purple loosestrife was 22.58±0.03 %, 3.28±0.01 %, 14.84±0.12 % & 20.32±0.15 %. The fatty acid profiles of these four species were determined by gas chromatography (using methyl esters of their fatty acids); Oleic acid and Linoleic acid were found in all the four species, Gamma-linolenic acid was found in Purple loosestrife & Alpha-linolenic acid was found in Oregano and Common Self-heal plant species. Thermal behaviour of these four plant seed oils were analyzed using Differential Scanning Calorimetry (DSC), while some other physicochemical properties of the seed oils were also analyzed. These plant seed oils can be of great commercial importance. [less ▲]

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See detailField bordering flower strips as source of lipids
Paul, Aman ULg; Danthine, Sabine ULg; Stephanie, Heuskin et al

Poster (2014, February 07)

Field bordering flower strips not just only improves the biodiversity but also serves as a source of beneficial compounds. Some of the plants in these strips can be really interesting source of lipids ... [more ▼]

Field bordering flower strips not just only improves the biodiversity but also serves as a source of beneficial compounds. Some of the plants in these strips can be really interesting source of lipids, the oils extracted from their seeds can be important for food, pharmaceutical and cosmetics industries. Six species of plants from flowering strips in Belgium were investigated for their seed oil content. The oil from seeds was extracted by cold extraction technique using chloroform/methanol in 2:1 ratio as solvent. Oil extraction from seeds of Red Clover (Trifolium pratense), Rough Hawkbit (Leontodon hispidus), Cow Parsley (Anthriscus sylvestris), St John’s Wort (Hypericum perforatum), Common Yarrow (Achillea millefollium) and Birdsfoot Trefoil (Lotus corniculatus) plant species was done on wet weight which came out to be 7.89±0.11%, 11.86±0.07%, 14.78±0.31%, 24.20±0.02%, 20.08±0.15% and 7.04±0.12% respectively. The physicochemical properties of the extracted oils were analyzed. Some of these oils can be of great commercial value. [less ▲]

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See detailBiodiversity and ecosystem services: think functional!
Uyttenbroeck, Roel ULg; Hatt, Séverin ULg; Paul, Aman ULg et al

Poster (2014, February 07)

During the last years, several studies and reviews have considered the relation between biodiversity and ecosystem functioning or the provision of ecosystem services. Many studies found that plant ... [more ▼]

During the last years, several studies and reviews have considered the relation between biodiversity and ecosystem functioning or the provision of ecosystem services. Many studies found that plant functional traits and plant functional diversity (FD) are key drivers in this relation in terrestrial ecosystems. Researchers used different methods to obtain a gradient in plant FD to examine the effect on ecosystem services, going from observational studies of natural communities to synthetic assemblages. Furthermore, different methods exist to quantify plant FD going from simple functional trait richness to indices, distance-based frameworks and the division into FD components. In the AgricultureIsLife project, we set up a field experiment aiming to examine the biodiversity – ecosystem service relation in agricultural context. The experiment consists of perennial wildflower strips with different plant functional diversities in an arable field with conventional crop production. The wildflower strips were sown as synthetic assemblages but are subject to natural succession during the following years. We monitor the evolution of FD from the sowing to the establishment of a typical wildflower strip using Rhao’s quadratic entropy index to quantify FD. In addition, the flower strips will be monitored for four ecosystem services they are expected to provide: pollination, pest control, biodiversity support and provision of valuable compounds. [less ▲]

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See detail« Les plantes qui nous soignent : de la tradition à la médecine moderne »
Frederich, Michel ULg

Scientific conference (2014, January 20)

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See detailAntiplasmodial anthraquinones and hemisynthetic derivatives from the leaves of Tectona grandis (Verbenaceae)
Kopa, T.K.; Tchinda Tiabou, Alembert ULg; Tala, M.F. et al

in Phytochemistry Letters (2014), 8

Chemical investigation of the methanol extract of the leaves of Tectona grandis led to the isolation of one new anthraquinone derivative, grandiquinone A (3-acetoxy-8-hydroxy-2-methylanthraquinone) (1 ... [more ▼]

Chemical investigation of the methanol extract of the leaves of Tectona grandis led to the isolation of one new anthraquinone derivative, grandiquinone A (3-acetoxy-8-hydroxy-2-methylanthraquinone) (1), along with nine known compounds: 5,8-dihydroxy-2-methylanthraquinone (2), hydroxysesamone (3), 3-hydroxy-2-methylanthraquinone (4), quinizarine (5), betulinic acid (6), ursolic acid (7), tectograndone (8), corosolic acid (9) and sitosterol 3-O-β-d-glucopyranoside (10). Compounds 2 and 3 were isolated for the first time from the leaves of this plant, while 5 has never been reported from the genus Tectona. Hydroxysesamone (3) and tectograndone (8) were subjected to cyclisation and acetylation reactions to afford two hemisynthetic derivatives, 6,9-dihydroxy-2,2-(dimethyldihydropyrano)-3,4-dihydro-2H-benzo[g]chromene-5,10-dione (11) and acetyltectograndone (12) respectively, which are reported here for the first time. The ethyl acetate-soluble portion, some of the isolated compounds and hemisynthetic derivatives were evaluated for their antiplasmodial activity against the multidrug-resistant Dd2 strain of Plasmodium falciparum. Compound 3 showed a prominent activity, while 2, 8, 9, 11 and 12 showed significant in vitro anti-malarial activity. Compound 1 was weakly active in this test. The structures of the compounds were elucidated by spectroscopic methods and comparison of the data with the literature. [less ▲]

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