References of "Franchimont, Paul"
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See detailSepsis and Serum Cytokine Concentrations
Damas, Pierre ULg; Canivet, Jean-Luc ULg; de Groote, Donat et al

in Critical Care Medicine (1997), 25(3), 405-12

OBJECTIVE: To look for relationships between the classification of sepsis and plasma cytokine concentrations. DESIGN: Prospective, consecutive entry study of patients meeting severe sepsis criteria and ... [more ▼]

OBJECTIVE: To look for relationships between the classification of sepsis and plasma cytokine concentrations. DESIGN: Prospective, consecutive entry study of patients meeting severe sepsis criteria and having bacteriologically documented infections. SETTING: University hospital, surgical intensive care unit. PATIENTS: Fifty consecutive patients developing severe sepsis or septic shock between December 1991 and December 1993. MEASUREMENTS AND MAIN RESULTS: Concentrations of tumor necrosis factor, interleukin (IL)-6, IL-8, and leukemia inhibitory factor were measured by immunoradiometric assay in the plasma of patients as soon as they developed severe sepsis or septic shock. Septic shock patients were divided into three groups in a blinded fashion (i.e., without knowing the results of the concentrations of cytokines), according to the presence of sustained hyperlactacidemia and to the rapidity of the onset of sepsis. Peak concentrations of all cytokines were statistically different between severe sepsis and septic shock patients. This finding was almost exclusively due to the data from patients with rapid onset of septic shock, who demonstrated very high but transient cytokine concentrations. Septic shock patients may thus have different profiles in the time course of their cytokine concentrations. The transient, high peak concentrations of cytokines were also related to transient leukopenia. Among the cytokines measured, IL-8 appeared to be the one that correlated best with lactacidemia, the presence of disseminated intravascular coagulation, severe hypoxemia, the Acute Physiology and Chronic Health Evaluation II score, and mortality rate. CONCLUSIONS: According to the profiles of the cytokines, septic shock patients do not represent a homogeneous population. These profiles should be described in order to distinguish between patients, and the profiles may be useful to identify those patients susceptible to new therapies. [less ▲]

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See detailEffects of iproflavone and its metabolites on human articular chondrocytes
Bassleer, Corinne; Franchimont, Paul; Henrotin, Yves ULg et al

in Osteoarthritis and Cartilage (1995), 4

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See detailOrganic silicon decreases interleukine-6 but not leukemia inhibitory factor in human osteoblast-like cells in vitro
Franchimont, Nathalie; Franchimont, Paul; Weekers, Laurent ULg et al

Poster (1995)

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See detailCryptocrine Signaling in the Thymus Network. Implications for Central T-Cell Tolerance of Neuroendocrine Functions
Geenen, Vincent ULg; Cormann-Goffin, Nadine; Vandersmissen, Eric et al

in Annals of the New York Academy of Sciences (1994), 741

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See detailUtilisation de prodelphinidines pour le traitement de l'arthrose
Franchimont, Paul; Bassleer, Corine; Angenot, Luc ULg et al

Patent (1994)

The subject of the invention is the use of prodelphinidins for obtaining medicaments intended for the treatment of articular pathologies associated with the destruction of the cartilage, and more ... [more ▼]

The subject of the invention is the use of prodelphinidins for obtaining medicaments intended for the treatment of articular pathologies associated with the destruction of the cartilage, and more particularly of arthrosis. [less ▲]

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See detailEffet de la prise de Condrosulf® 400 dans l'arthrose d'Heberden et de Bouchard
WANG, François-Charles ULg; Collignon, Laurent; REGINSTER, Jean-Yves ULg et al

Conference (1994)

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See detailThe education of developing T cells in neuroendocrine self principles: Evidence for an evolutionary continuum of immunoendocrine interactions
Geenen, Vincent ULg; Franchimont, Paul

in Savage, Martin O.; Bourguignon, Jean-Pierre; Grossman, Ashley B. (Eds.) Frontiers in Pediatric Neuroendocrinology (1994)

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See detailLes choix stratégiques actuels dans la prévention du processus diabétogène auto-immun
Geenen, Vincent ULg; Martens, Henri ULg; Kecha, Ouafae et al

in Médecine et Hygiène (1994), 52

Le diabète insulino-dépendant (DID) est de plus en plus admis comme résultant d'une rupture de la tolérance immunitaire vis-à-vis de la cellule ß pancréatique. La compréhension des mécanismes centraux et ... [more ▼]

Le diabète insulino-dépendant (DID) est de plus en plus admis comme résultant d'une rupture de la tolérance immunitaire vis-à-vis de la cellule ß pancréatique. La compréhension des mécanismes centraux et périphériques de la tolérance vis-à-vis de la cellule ß doit logiquement aboutir à une prévention non toxique et efficace du DID. Deux choix stratégiques sont proposés à l'heure actuelle. D'une part, la tolérance périphérique à l'insuline en tant que cible du processus auto-immun pourrait être restaurée via l'administration d'insuline à faibles doses par voie sous-cutanée ou orale. D'autre part, le facteur de croissance apparenté à l'insuline de type 2 (IGF2) pourrait réinduire la tolérance centrale de l'insuline et, secondairement, de la cellule ß insulino-sécrétrice. [less ▲]

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See detailThe education of developing T cells in neuroendocrine self principles: Evidence for an evolutionary continuum of immunoendocrine interactions
Geenen, Vincent ULg; Franchimont, Paul

in Savage, Martin O.; Bourguignon, Jean-Pierre; Grossman, Ashley B. (Eds.) Frontiers in Pediatric Neuroendocrinology (1994)

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See detailThymic neuroendocrine self peptides and T-cell selection
Geenen, Vincent ULg; Martens, Henri ULg; Vandersmissen, Eric et al

in Heinen, Ernst; Defresne, Marie-Paule; Boniver, Jacques (Eds.) et al In Vivo Immunology - Regulatory Processes during Lymphopoiesis and Immunopoiesis (1994)

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See detailThe Dual Role of Thymic Neurohypophysial-Related Self Peptides in T Cell Selection. Physiological and Pharmacological Implications
Geenen, Vincent ULg; Martens, Henri ULg; Robert, Françoise et al

in Annals of the New York Academy of Sciences (1993), 689

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See detailThymic neurohypophysial-related peptides and T cell selection
Geenen, Vincent ULg; Cormann-Goffin, Nadine; Martens, Henri ULg et al

in Regulatory Peptides (1993), 45(1-2), 273-278

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See detailEvidence that insulin-like growth factor 2 (IGF2) is the dominant thymic peptide of the insulin superfamily
Geenen, Vincent ULg; Achour, Imane; Robert, Françoise et al

in Thymus (1993), 21(2), 115-127

Central T-cell tolerance of neurondocrine functions has been proposed to be primarily induced by the thymic repertoire of neuroendocrine self antigens. The present study aimed at characterizing the human ... [more ▼]

Central T-cell tolerance of neurondocrine functions has been proposed to be primarily induced by the thymic repertoire of neuroendocrine self antigens. The present study aimed at characterizing the human thymic insulin-related self antigen able to represent the pancreatic islet ß cell function in face of the developing T cells. Immunofluorescence studies were performed on human and rat thymic sections, as wess as on the rat IT-45R1 thymic epithelial cell line using several antibodies to epitopes of the insulin peptide family. These studies identify beyond any doubt that IGF2 is the dominant thymic peptide of the insulin family. The sequence of an insulin-derived autoantigen is proposed. This autoantigen is a nonamer and has a hydrophobic residue leucine at position 9. In human species, this autoantigen would primarily be tolerogenic for the pancreatic ß-cell endocrine function during fetal development. [less ▲]

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See detailEvidence for the association between human thymic MHC class I molecules and a dominant neurohypophysial thymic peptide
Geenen, Vincent ULg; Vandersmissen, Eric; Martens, Henri ULg et al

in Journal of Immunology (1993), 150

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See detailEvidence that insulin-like growth factor 2 (IGF2) is the dominant thymic peptide of the insulin superfamily
Geenen, Vincent ULg; Achour, Imane; Martens, Henri ULg et al

in The Endocrine Society (Ed.) Proceedings of the 75th Annual Meeting of the Endocrine Society (1993)

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See detailThe central role of the thymus in the education of T cells to neuroendocrine self principles
Geenen, Vincent ULg; Martens, Henri ULg; Cormann-Goffin, Nadine et al

in Archives Internationales de Physiologie et de Biochimie (1993), 101

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See detailCytokine serum level during severe sepsis in human Il-6 as a marker of severity
Damas, Pierre ULg; Ledoux, Didier ULg; Nys, Monique ULg et al

in Annals of Surgery (1992), 215(4), 356-362

Forty critically ill surgical patients with documented infections were studied during their stay in an intensive care unit. Among these patients, 19 developed septic shock and 16 died, 9 of them from ... [more ▼]

Forty critically ill surgical patients with documented infections were studied during their stay in an intensive care unit. Among these patients, 19 developed septic shock and 16 died, 9 of them from septic shock. Interleukin 1 beta (IL-1 beta), tumor necrosis factor (TNF alpha), and interleukin 6 (IL-6) were measured each day and every 1 or 2 hours when septic shock occurred. Although IL-1 beta was never found, TNF alpha was most often observed in the serum at a level under 100 pg/mL except during septic shock. During these acute episodes TNF alpha level reached several hundred pg/mL, but only for a few hours. In contrast, IL-6 was always increased in the serum of acutely ill patients (peak to 500,000 pg/mL). There was a direct correlation between IL-6 peak serum level and TNF alpha peak serum level during septic shock and between IL-6 serum level and temperature or C-reactive protein serum level. Moreover, IL-6 correlated well with APACHE II score, and the mortality rate increased significantly in the group of patients who presented with IL-6 serum level above 1000 pg/mL. Thus, IL-6 appears to be a good marker of severity during bacterial infection. [less ▲]

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See detailOrales Chondroïtinsulfat bei Arthrose
WANG, François-Charles ULg; Collignon, Laurent; REGINSTER, Jean-Yves ULg et al

in Litera Rheumatologica (1992)

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See detailEtude de l'efficacité du Valtran® gouttes chez des patients atteints de lombarthrose
WANG, François-Charles ULg; Franchimont, Paul

in Medical Trends (1992)

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See detailNouvelles approches pharmacologiques basées sur les interactions neuroendocrino-immunitaires
Geenen, Vincent ULg; Franchimont, Nathalie; Louis, Edouard ULg et al

in Médecine et Hygiène (1992), 50

La description des interactions neuroendocrino-immunitaires a été un domaine de recherche très fructueux au cours des dernières années. Si les circonstances physiopathologiques au cours desquelles ces ... [more ▼]

La description des interactions neuroendocrino-immunitaires a été un domaine de recherche très fructueux au cours des dernières années. Si les circonstances physiopathologiques au cours desquelles ces interactions interviennent restent encore à préciser, la caractérisation biochimique de signaux neuropeptidiques et de leurs récepteus exprimés par des cellules immunocompétentes permet d'entrevoir de nouvelles possibilités thérapeutiques. En particulier, l'action immunomodulatrice et antiinflammatoire potentielle d'antagonistes spécifiques de neuropeptides représente une voie intéressante pour la mise au point d'immunothérapies sélectives. [less ▲]

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