Implication des propriétés biomécaniques des muscles transformés dans le mécanisme de la cardiomyoplastie

in Journal of Cardiology (1999), 9

Selection and identification of lumped models of the arterial vasculature using multiple regression and backward elimination in the time domain

in Medical & Biological Engineering & Computing (1996), 34

Effects of PEEP on abdominal aortic input impedance

in Intensive Care Medicine (1996), 22

Effects of PEEP on systemic vascular compliance in intact pigs

in Pflügers Archiv : European Journal of Physiology (1995), 430

Lung fluid balance and septic shock

in Chicago (1975) (1989)

A comparison of single bolus endotoxin injection with low-dose endotoxin infusion on pulmonary and systemic vascular changes in intact anesthetized dogs

in Circulatory Shock (1987), 21

Lack of defective cardiac oxidative metabolism in intact dogs subjected to a prolonged low - dose infusion of E. Coli endotoxin

in Circulatory Shock (1986), 18

Early changes in myocardial carbohydrate oxidative metabolism during E. Coli endotoxin infusion in dog

in Archives Internationales de Physiologie et de Biochimie (1985), 93

Effect of protein-supplemented fasting on the fuel-hormone response to prolonged exercise in obese subjects.

in International Journal of Obesity & Related Metabolic Disorders (1983), 7(4), 327-37

This study aimed at investigating the influence of protein-supplemented fasting (PSF) on the tolerance and the fuel-hormone response to endurance exercise in the severely obese subject. For this purpose ... [more ▼]

This study aimed at investigating the influence of protein-supplemented fasting (PSF) on the tolerance and the fuel-hormone response to endurance exercise in the severely obese subject. For this purpose, eight obese men (27 +/- 2 yr, 182 +/- 7 per cent of ideal body weight) exercised on a horizontal treadmill (4 km/h) during 3 h before and after 13 d of PSF (Alburone, 70 g protein/day). Because of the 8.9 +/- 0.7 kg weight loss and the corresponding lower energy cost, exercise oxygen consumption decreased from 1.6 +/- 0.1 (before PSF) to 1.4 +/- 0.1 l/min (after PSF). In contrast, mean exercise heart rate was identical (119 +/- 5/min) in both conditions, resulting in a lower oxygen pulse after PSF. The mean respiratory quotient measured during exercise was lower after PSF (0.72 +/- 0.01 vs 0.75 +/- 0.01 2 P less than 0.05), thus demonstrating a higher fat utilization. This was supported by a higher exercise-induced plasma free fatty acid (FFA) mobilization after PSF (delta plasma FFA: + 675 +/- 101 vs + 376 +/- 121 mumol/l, 2 P less than 0.05). This metabolic adaptation mainly results from two mechanisms: a significantly lower plasma IRI at rest and during exercise after PSF (5.7 +/- 0.8 vs 11.4 +/- 1.4 microunits/ml, 2 P less than 0.001); and a lower basal blood glucose (4.2 +/- 0.2 vs 4.6 +/- 0.1 mmol/l) and an earlier decrease of glucose (30th vs 90th min) during exercise after PSF, suggesting a relative depletion of the carbohydrates stores. The lipolytic hormones (glucagon, epinephrine, norepinephrine, cortisol, growth hormone) did not significantly increase during exercise after PSF when compared to exercise before PSF; thus, their role in the enhanced FFA mobilization appears less important. Only two of our eight subjects were unable to achieve the third hour of exercise after PSF; however, no major clinical events or electrocardiographical disturbances were observed in any of the eight subjects. In conclusion, moderate exercise can be tolerated at least for 2 h during PSF when appropriate fluid, mineral and vitamin therapy is given. Under these conditions it induces a preferential utilization of fat-derived substrates and selectively augments fat mobilization which favors weight loss. For these reasons, moderate exercise can be recommended under strict medical supervision as part of all weight reduction therapy. [less ▲]