References of "Flandroy, P"
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See detailLe cathétérisme bilatérale des sinus pétreux avec dosages multihormonaux dans la maladie de Cushing
Valdes Socin, Hernan Gonzalo ULg; Bataille, Yoann ULg; Meurisse, Nicolas ULg et al

in Annales d'Endocrinologie (2002), 63(1), 23-30

Multihormonal bilateral petrosal sinus sampling (BPSS) has been proposed to improve corticotroph microadenomas prediction of lateralisation. Few series have simultaneously compared data of pituitary MRI ... [more ▼]

Multihormonal bilateral petrosal sinus sampling (BPSS) has been proposed to improve corticotroph microadenomas prediction of lateralisation. Few series have simultaneously compared data of pituitary MRI, surgical findings and multihormonal BPSS. Seven patients (6F/1M) with Cushing's disease, mean age at diagnosis of 35 years (range 24-55) were prospectively studied to compare radiological and multihormonal BPSS data with surgical and pathological findings. In untreated patients, simultaneous measures of ACTH, TSH and prolactine (PRL) were done at time 0, 7, 15, 22 minutes after CRH (500 mg) and TRH (200 mg) stimulation. An intersinus gradient of 1.4 was considered as a lateralisation. All microadenomas were identified during surgery, diameters ranged from 2 to 7 mm. All patients were in long-term surgical remission. Pathological studies confirmed a tumoral tissue with ACTH immunostaining in 6/7 cases and PRL in 3/7 cases. Pituitary MRI correctly identified tumors in 4 cases, the remaining tumors were not seen. Basal and stimulated intersinus gradients of ACTH, TSH and PRL were homolateral in 6/7 cases and were coincident with surgical findings in 4/7 cases. The other three cases were contralateral to MRI and surgical data. In conclusion, simultaneous gradient of ACTH, PRL and TSH did not improve lateralisation prediction in this series. Hormonal hypersecretion was homolateral in six cases whereas pathological studies demonstrated a mixed secretion in only three cases. A preferential pituitary draining could explain these discordances. Data from our series and from others (done with CRH stimulation and ACTH-PRL measures) strongly suggest a paracrine interaction between tumoral and normal pituitary tissue. [less ▲]

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See detailExtensive inflammatory pseudotumor of the pituitary.
Hansen, Isabelle ULg; Petrossians, Patrick ULg; Thiry, Albert ULg et al

in Journal of Clinical Endocrinology and Metabolism (2001), 86(10), 4603-4610

A 40-yr-old female presented with an extensive lesion of the sellar area and the sphenoid sinus, spreading to the optic nerves and associated with pachymeningitis. Histological findings were consistent ... [more ▼]

A 40-yr-old female presented with an extensive lesion of the sellar area and the sphenoid sinus, spreading to the optic nerves and associated with pachymeningitis. Histological findings were consistent with an inflammatory pseudotumor, and steroid treatment allowed the disappearance of all the lesions. Inflammatory pseudotumors of the pituitary are very rare. This case appears unique with regard to the extension of the lesions and the dramatic response to medical treatment. The differential diagnosis of inflammatory lesions of the pituitary is difficult. It relies mainly on histological analysis and includes sarcoidosis, Wegener's granulomatosis, histiocytosis (Langerhans, Rosai-Dorfman, and Erdheim-Chester diseases) and lymphocytic hypophysitis. [less ▲]

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See detailSurgical outcome inagromecalics treated with somatostatin analogues before surgery
Stevenaert, Achille ULg; Valdes Socin, Hernan Gonzalo ULg; Flandroy, P. et al

in 5th European Congress of Endocrinology - Abstract book (2001)

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See detailApport du cathétérisme des sinus pétreux inférieux (CSPI) dans la prédiction de la localisation d'un adénome hypophysaire
Valdes Socin, Hernan Gonzalo ULg; Bataille, Yoann ULg; Meurisse, Nicolas ULg et al

in Annales d'Endocrinologie : XIXe Congrès de la Société Française d'Endocrinologie - Abstract book (2001)

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See detailRésultats de la chirurgie trans-sphénoïdale chez les acromégales traités par analogues de la somatostatine avant chirurgie
Stevenaert, Achille ULg; Valdes Socin, Hernan Gonzalo ULg; Flandroy, P. et al

in Annales d'Endocrinologie : XIXe Congrès de la Société Française d'Endocrinologie - Abstract book (2001)

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See detailAn unusual pituitary pathology
Petrossians, Patrick ULg; Delvenne, Philippe ULg; Flandroy, P. et al

in Journal of Clinical Endocrinology and Metabolism (1998), 83(10), 3454-3458

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See detailMRI of a presumptive trigeminal nerve tumor in a seven years old husky dog : a case report and review of the litterature
Saunders, J.; Clercx, Cécile ULg; Poncelet, Luc et al

in Veterinary Radiology & Ultrasound (1998), 39

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See detailComparative Evaluation of Cerebral Aneurysms with Selective Arterially Enhanced Ct and Dsa
Vanderschelden, P.; Flandroy, P.; Dondelinger, R. F. et al

in European Radiology (1998), 8(7), 1181-6

The purpose of our study was to compare selective arterially enhanced spiral computed tomographs (ACT) with digital subtraction angiographies (DSA) in the presurgical assessment of cerebral aneurysms. A ... [more ▼]

The purpose of our study was to compare selective arterially enhanced spiral computed tomographs (ACT) with digital subtraction angiographies (DSA) in the presurgical assessment of cerebral aneurysms. A total of 24 aneurysms in 18 patients were explored in a prospective study by ACT and DSA, using an interactive combined CT-angiography suite. Dimensions of the aneurysm, its relation to the parent vessel, and the aneurysmal index were defined on DSA and on surface-shaded display of 3D reformatted images obtained from ACT. Results were correlated with surgical findings. Three aneurysms suspected on DSA were not confirmed by ACT. One fusiform aneurysm suspected on DSA corresponded to a sacciform aneurysm on ACT. Surgical findings confirmed 20 sacciform aneurysms. The aneurysmal index could be measured in all 20 cases of sacciform aneurysms on ACT and could not be determined with confidence in 55 % of the cases on DSA. DSA and ACT gave identical results in 35 % of cases. In 10 %, the index measured by ACT was superior to that determined by DSA for aneurysms which had a diameter of less than 3 mm. In conclusion, the combination of DSA and ACT improved the results of DSA alone. ACT is a reliable method to measure the aneurysmal index in aneurysms with a diameter superior to 3 mm. [less ▲]

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See detailIn vivo behavior of poly(D,L)-lactide microspheres designed for chemoembolization
Flandroy, P.; Grandfils, Christian ULg; Danen, B. et al

in Journal of Controlled Release (1997), 44(2-3), 153-170

Although chemoembolization advantageously combines arterial embolization of the vascular supply of a neoplasm with controlled intra-arterial infusion of chemotherapeutic drug(s), its application is ... [more ▼]

Although chemoembolization advantageously combines arterial embolization of the vascular supply of a neoplasm with controlled intra-arterial infusion of chemotherapeutic drug(s), its application is limited by the lack of appropriate and reliable embolization materials. Recently, calibrated microspheres of poly(D,L)-lactide have proved to be promising in embolization. Nevertheless, repetitive chemoembolization requires the availability of microspheres degradable within a few days. For this purpose, microspheres consisting of a blend of two polyesters of a very different molecular weight (Mn =65 000 and 3500 in a 16:84 wt. ratio) have been prepared and injected in the renal arteries of rabbits. The in vivo fate of these two component microspheres has been compared by radiology and histology to microspheres prepared from the high molecular weight poly(D,L)-lactide. Furthermore, the in vivo degradation of the polymer has been measured by size exclusion chromatography after quantitative reextraction from the embolized kidney. Degradation kinetics has been compared to data previously reported in vitro. According to the observations performed during the in vivo study, the 50/50 microspheres appear more useful for the chemoembolization of tumors. [less ▲]

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See detailIntraarterial spiral CT angiography combined with DSA in pretherapeutic assessment of cerebral aneurysms.
Flandroy, P.; Vanderschelden, P.; Dondelinger, Robert ULg et al

Conference (1996, September 21)

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See detailUtilisation des microsphères biodégradables en thérapie anti-cancéreuse expérimentale. Application chronopharmacologique
Milis, G.; Grandfils, Christian ULg; Flandroy, P. et al

in Pathologie Biologie (1996), 44(3), 208-11

We describe the initial experimentations which show that is possible to chronomodulate the cisplatin liberation out of some microspheres. The goal is to generate, inside one tumeur embolished by those ... [more ▼]

We describe the initial experimentations which show that is possible to chronomodulate the cisplatin liberation out of some microspheres. The goal is to generate, inside one tumeur embolished by those cisplatin loaded microspheres, some concentration peaks at the best tolerance time. The cancer is than more hit, by the high local anticancer drug concentration, and doses chronomodulations preserve the patient by following his tolerance. The experimentation on cancerous mice show that this technique could lead to great survival increases. Such a protocol might usefuly improve the anticancer therapy. [less ▲]

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See detailControl of the biodegradation rate of poly(DL-lactide) microparticles intended as chemoembolisation materials
Grandfils, Christian ULg; Flandroy, P.; Jérôme, Robert ULg

in Journal of Controlled Release (1996), 38(2-3), 109-122

There is an interest in polylactide microspheres that biodegrade within a few days, particularly for chemoembolization applications. For this purpose, two poly(DL-lactide) samples of a very different ... [more ▼]

There is an interest in polylactide microspheres that biodegrade within a few days, particularly for chemoembolization applications. For this purpose, two poly(DL-lactide) samples of a very different molecular weight have been combined. The basic concept relies upon the capability of the high molecular weight component (Mn: 65 000) to provide the microspheres with a high mechanical strength, whereas the low molecular weight component (Mn: 3500) should decrease the particle lifetime dramatically. It has been shown that changing the weight ratio of these two components is an efficient way to control the kinetics of the in vitro degradation of poly(DL-lactide) microspheres on the expected time scale. The microspheres have been prepared by the oil-in-water emulsion/evaporation process, and their final polymer content has been compared to the initial composition of the oil phase. They have also been analyzed by differential scanning calorimetry to know whether the two polymers form a monophase blend or not. Kinetics of the in vitro biodegradation has been estimated from the decrease in molecular weight of the constitutive poly(DL-lactide)s, the time-dependency of the microsphere weight and the observation of changes in the morphology by scanning electron microscopy. Progress in the hydrolysis of the ester groups has also been reckoned from the increasing acidity of the incubation medium and associated with the polymer. [less ▲]

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See detailPretherapeutic assessment of cerebral aneuvrysms with arterially enhanced spiral CT
Vanderschelden, P.; Flandroy, P.; Dondelinger, Robert ULg et al

Conference (1995, November 26)

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See detail132. Intrasellar arachnoïd cysts: diagnosis and treatment
Dubuisson, Annie ULg; Martin, Didier ULg; Bruggeman, L. et al

Conference (1995, May 07)

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See detailIntrasellar Arachnoïd Cysts: Diagnosis, Management, and Pathophysiology.
Dubuisson, Annie ULg; Martin, Didier ULg; Bruggeman, L. et al

Conference (1995, April 22)

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See detailContribution de la chimie macromoléculaire à l'élaboration de matériaux colloïdaux et microparticulaires destinés à la vectorisation de médicaments
Grandfils, Christian ULg; Flandroy, P.; Jérôme, Robert ULg

in Innovation et Technologies en Biologie et en Médecine (1995), 16

Various colloidal and microparticular vector have been tailored during the last few years in order to promote the transport , the protection and the orientation of the drug towards its pharmacological ... [more ▼]

Various colloidal and microparticular vector have been tailored during the last few years in order to promote the transport , the protection and the orientation of the drug towards its pharmacological target. The aim of the paper is to give some insight about the contribution of the macromolecular engineering for the development of two vectors : microparticles of a control biodegradation rate designed for the chemoembolization of hepatocarcinoma , amphiphile copolymeric micelles able to transport drug within the targeted cells. Starting from a synthetic polymer : polylactide, degradation rate caracteristics , and functionalities can be tailored for the intended applications. One of the major problems , and largely underestimated in the past , for the successfull design of polymeric carrier is to take into account the interaction of proteins with polymer surfaces. [less ▲]

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