References of "Felekidis, Apostolos"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailPreparation and pharmacological evaluation of the R- and S-enantiomers of 3-(2’-butylamino)-4H- and 3-(3’-methyl-2’-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide, two tissue selective ATP-sensitive potassium channel openers
Khelili, S.; De Tullio, Pascal ULiege; Lebrun, P. et al

in Bioorganic & Medicinal Chemistry (1999), 7(8), 1513-1520

The preparation and the pharmacological evaluation of the R- and S-isomers of 3-(2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 42) and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4 ... [more ▼]

The preparation and the pharmacological evaluation of the R- and S-isomers of 3-(2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 42) and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 44), two potassium channel openers, is described. Their optical purity was estimated by means of capillary electrophoresis (R- and S-BPDZ 42) and chiral HPLC (R- and S-BPDZ 44). The absolute configuration of each isomer of BPDZ 44 was deduced from crystallographic data. Pharmacological assays performed with the R- and S-isomers of BPDZ 44 revealed only slight differences in their activity on pancreatic B-cells but significant differences in their activity on vascular smooth muscle cells: the R-isomer being sixfold more potent than its corresponding S-isomer. The R-isomer of BPDZ 42 was shown to be more potent than its corresponding S-isomer on the endocrine pancreas. S-BPDZ 44 as well as R- and S-BPDZ 42 were found to exhibit tissue selectivity for the pancreatic versus the vascular smooth muscle tissue. [less ▲]

Detailed reference viewed: 23 (1 ULiège)
Full Text
Peer Reviewed
See detailEffective resolution of racemic pirlindole at the preparative scale
De Tullio, Pascal ULiege; Ceccato, A.; Liégeois, Jean-François ULiege et al

in Chirality (1999), 11

Detailed reference viewed: 27 (6 ULiège)
Peer Reviewed
See detailSéparation énantiomérique du pirlindole à l’échelle préparative
De Tullio, Pascal ULiege; Ceccato, A.; Felekidis, Apostolos ULiege et al

Poster (1998, January 16)

Detailed reference viewed: 9 (0 ULiège)
Peer Reviewed
See detailTentatives de synthèse énantiosélective des isomères R et S du pirlindole
Pirotte, Bernard ULiege; De Tullio, Pascal ULiege; Stachow, M. et al

in Journal de Pharmacie de Belgique (1998), 53

Detailed reference viewed: 29 (2 ULiège)
Peer Reviewed
See detailPreparative resolution of racemic pirlindole: chromatographic methods and determination of the absolute configuration
De Tullio, Pascal ULiege; Ceccato, A.; Liégeois, Jean-François ULiege et al

in European Journal of Pharmaceutical Sciences (1998), suppl.1

Detailed reference viewed: 32 (3 ULiège)
Peer Reviewed
See detailRésolution préparative du pirlindole
De Tullio, Pascal ULiege; Felekidis, Apostolos ULiege; Liégeois, Jean-François ULiege et al

in Journal de Pharmacie de Belgique (1998), 53

Detailed reference viewed: 26 (3 ULiège)
Peer Reviewed
See detailRésolution préparative du pirlindole
De Tullio, Pascal ULiege; Felekidis, Apostolos ULiege; Liégeois, Jean-François ULiege et al

Poster (1997, May)

Detailed reference viewed: 15 (0 ULiège)
Peer Reviewed
See detailTentatives de synthèse énantiosélective des isomères R et S du pirlindole
Pirotte, Bernard ULiege; De Tullio, Pascal ULiege; Stachow, M. et al

Poster (1997, May)

Detailed reference viewed: 13 (0 ULiège)
Peer Reviewed
See detailStereoselective hydrogenation of methacycline to doxycycline catalysed by rhodium-carborane complexes
Fontaine, M.; Demonceau, Albert ULiege; Noels, A. F. et al

Poster (1993, July)

Detailed reference viewed: 33 (0 ULiège)
Full Text
Peer Reviewed
See detailStereoselective hydrogenation of methacycline to doxycycline catalysed by rhodium-carborane complexes
Pirotte, Bernard ULiege; Felekidis, Apostolos ULiege; Fontaine, M. et al

in Tetrahedron Letters (1993), 34

Detailed reference viewed: 28 (1 ULiège)
Peer Reviewed
See detailStereoselective hydrogenation of methacycline to doxycycline catalysed by rhodium-carborane complexes
Fontaine, M.; Demonceau, Albert ULiege; Noëls, A. F. et al

Poster (1992, November)

Detailed reference viewed: 15 (1 ULiège)