References of "Felekidis, Apostolos"
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See detailPreparation and pharmacological evaluation of the R- and S-enantiomers of 3-(2’-butylamino)-4H- and 3-(3’-methyl-2’-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide, two tissue selective ATP-sensitive potassium channel openers
Khelili, S.; De Tullio, Pascal ULg; Lebrun, P. et al

in Bioorganic & Medicinal Chemistry (1999), 7(8), 1513-1520

The preparation and the pharmacological evaluation of the R- and S-isomers of 3-(2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 42) and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4 ... [more ▼]

The preparation and the pharmacological evaluation of the R- and S-isomers of 3-(2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 42) and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 44), two potassium channel openers, is described. Their optical purity was estimated by means of capillary electrophoresis (R- and S-BPDZ 42) and chiral HPLC (R- and S-BPDZ 44). The absolute configuration of each isomer of BPDZ 44 was deduced from crystallographic data. Pharmacological assays performed with the R- and S-isomers of BPDZ 44 revealed only slight differences in their activity on pancreatic B-cells but significant differences in their activity on vascular smooth muscle cells: the R-isomer being sixfold more potent than its corresponding S-isomer. The R-isomer of BPDZ 42 was shown to be more potent than its corresponding S-isomer on the endocrine pancreas. S-BPDZ 44 as well as R- and S-BPDZ 42 were found to exhibit tissue selectivity for the pancreatic versus the vascular smooth muscle tissue. [less ▲]

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See detailEffective resolution of racemic pirlindole at the preparative scale
De Tullio, Pascal ULg; Ceccato, A.; Liégeois, Jean-François ULg et al

in Chirality (1999), 11

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See detailSéparation énantiomérique du pirlindole à l’échelle préparative
De Tullio, Pascal ULg; Ceccato, A.; Felekidis, Apostolos ULg et al

Poster (1998, January 16)

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See detailTentatives de synthèse énantiosélective des isomères R et S du pirlindole
Pirotte, Bernard ULg; De Tullio, Pascal ULg; Stachow, M. et al

in Journal de Pharmacie de Belgique (1998), 53

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See detailPreparative resolution of racemic pirlindole: chromatographic methods and determination of the absolute configuration
De Tullio, Pascal ULg; Ceccato, A.; Liégeois, Jean-François ULg et al

in European Journal of Pharmaceutical Sciences (1998), suppl.1

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See detailRésolution préparative du pirlindole
De Tullio, Pascal ULg; Felekidis, Apostolos ULg; Liégeois, Jean-François ULg et al

in Journal de Pharmacie de Belgique (1998), 53

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See detailTentatives de synthèse énantiosélective des isomères R et S du pirlindole
Pirotte, Bernard ULg; De Tullio, Pascal ULg; Stachow, M. et al

Poster (1997, May)

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See detailStereoselective hydrogenation of methacycline to doxycycline catalysed by rhodium-carborane complexes
Fontaine, M.; Demonceau, Albert ULg; Noels, A. F. et al

Poster (1993, July)

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See detailStereoselective hydrogenation of methacycline to doxycycline catalysed by rhodium-carborane complexes
Pirotte, Bernard ULg; Felekidis, Apostolos ULg; Fontaine, M. et al

in Tetrahedron Letters (1993), 34

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See detailStereoselective hydrogenation of methacycline to doxycycline catalysed by rhodium-carborane complexes
Fontaine, M.; Demonceau, Albert ULg; Noëls, A. F. et al

Poster (1992, November)

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