References of "FLAGOTHIER, Caroline"
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See detailA four-generation Ehlers-Danlos syndrome with vascular dissections. Skin ultrastructure and biomechanical properties.
Flagothier, Caroline ULg; Goffin, Véronique ULg; Hermanns-Le, Trinh ULg et al

in Journal of Medical Engineering & Technology (2007), 31(3), 175-80

Ehlers-Danlos syndrome (EDS) is heterogenous with regard to genetic traits, clinical manifestation, the biomechanical and microscopic properties of connective tissues, and basic molecular defects. We ... [more ▼]

Ehlers-Danlos syndrome (EDS) is heterogenous with regard to genetic traits, clinical manifestation, the biomechanical and microscopic properties of connective tissues, and basic molecular defects. We report on nine relatives of four generations who suffered from large vessel dissections and cutaneous microscopic changes consistent with EDS. Measurements of the mechanical properties of skin were performed using a computerized suction device (Cutometer). Morphological and biomechanical alterations suggestive of EDS were present in all examined subjects. A loose network of collagen bundles was admixed with clumsy elastic fibres. Factor XIIIa-positive dermal dendrocytes looked almost normal but were slim and rarefied in four subjects. The severity in ultrastructural alterations of the collagen network differed among the subjects. The group with the most prominent changes showed the most striking biomechanical alterations characterized by increased biologic elasticity without any excess in skin extensibility. A positive correlation was found between skin extensibility and elasticity. In conclusion, distinct alterations in the collagen scaffolding were found to be correlated to variable severity in biomechanical alterations of the skin. The predictive value of these changes for large vessel dissections in some families at risk remains to be settled. [less ▲]

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See detailComment je traite... un intertrigo lie a l'embonpoint.
Henry, Frédérique ULg; Pierard, Claudine ULg; Flagothier, Caroline ULg et al

in Revue Médicale de Liège (2007), 62(2), 67-70

Intertrigo is a common inflammatory disorder of various origins. It can represent a single skin manifestation or be part of a disorder possibly exhibiting specific manifestations on other parts of the ... [more ▼]

Intertrigo is a common inflammatory disorder of various origins. It can represent a single skin manifestation or be part of a disorder possibly exhibiting specific manifestations on other parts of the body. Hence, intertrigo may represent a sign of a peculiar disease. It may also result from physicochemical aggressions of the skin following occlusion of the large skinfolds particularly in case of stoutness. In this intance, a treatment similar to that of diaper dermatitis can be offered. A paste enriched or not with miconazole nitrate is indicated to prevent or treat most presentations of intertrigo. [less ▲]

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See detailLipolyse electromagnetique et lipoatrophie semi-circulaire des cuisses
Flagothier, Caroline ULg; Quatresooz, Pascale ULg; Pierard, Gérald ULg

in Annales de Dermatologie et de Vénéréologie (2006), 133(6-7, Jun-Jul), 577-80

INTRODUCTION: The semicircular lipoatrophy of the thighs is a disorder whose incidence remained rare for years. Only recently, an "epidemic" situation emerged, affecting hundreds of subjects who shared a ... [more ▼]

INTRODUCTION: The semicircular lipoatrophy of the thighs is a disorder whose incidence remained rare for years. Only recently, an "epidemic" situation emerged, affecting hundreds of subjects who shared a status of administrative employee. OBSERVATION: The older etiopathogenic hypotheses give way to a newer one implying the electromagnetic fields generated by computers and their wirings. The resulting modifications in the intrinsic bioelectrical properties of the skin could influence the biology of macrophages exhibiting lipophagic activity in the hypodermis. The electroactivation of these cells could lead to TNF-alpha release. DISCUSSION: The semicircular lipoatrophy of the thighs is a problem that may affect an employee out of two. Rather than hoping an efficaceous drug therapy, prevention must be advocated by adapting the work conditions related to the use of computerized devices. [less ▲]

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See detailCutaneous myospherulosis and membranous lipodystrophy: extensive presentation in a patient with severe steroid-induced dermal atrophy.
Flagothier, Caroline ULg; Pierard, Gérald ULg; Quatresooz, Pascale ULg

in Journal of the European Academy of Dermatology & Venereology (2006), 20(4), 457-60

Myospherulosis is a rare disorder that may develop in various organs including the skin. It is characterized by a typical histological presentation resulting from the interaction between erythrocytes and ... [more ▼]

Myospherulosis is a rare disorder that may develop in various organs including the skin. It is characterized by a typical histological presentation resulting from the interaction between erythrocytes and lipids. We present a case of cutaneous myospherulosis associated with membranous lipodystrophy. The lesions were supervening on severe steroid-induced skin atrophy upon which ointments had been applied. [less ▲]

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See detailCutaneous mucormycosis.
Flagothier, Caroline ULg; Arrese Estrada, Jorge ULg; Quatresooz, Pascale ULg et al

in Journal de Mycologie Médicale (2006), 16

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See detailComment je traite ... un psoriasis en plaques par l'association calcipotriol-dipropionate de betamethasone.
Henry, Frédérique ULg; Flagothier, Caroline ULg; Franchimont, Claudine ULg et al

in Revue Médicale de Liège (2006), 61(3), 139-41

The combination of calcipotriol and betamethasone dipropionate in a single topical formulation is a recent advance in treatment of plaque type psoriasis. Studies rooted on evidence-based medicine have ... [more ▼]

The combination of calcipotriol and betamethasone dipropionate in a single topical formulation is a recent advance in treatment of plaque type psoriasis. Studies rooted on evidence-based medicine have been recently published. We report a synthesis and a critical analysis, critical analysis of these investigations, and translate their data with a view to apply them in daily practice. [less ▲]

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See detailEffect of a single overnight topical application of miconazole nitrate paste on acne papules.
Flagothier, Caroline ULg; Vroome, Valerie; Borgers, Marcel et al

in International Journal of Dermatology (2006), 45(3), 316-9

BACKGROUND: The classical management of acne calls for prolonged oral and/or topical treatments; however, some patients request a rapid effect to make the papules disappear within a few hours or days ... [more ▼]

BACKGROUND: The classical management of acne calls for prolonged oral and/or topical treatments; however, some patients request a rapid effect to make the papules disappear within a few hours or days. OBJECTIVE: To test the effect of a single overnight application of a paste containing 0.25% miconazole nitrate on acne papules, and comparison with the effect of the same but unmedicated paste. METHOD: Narrow-band reflectance spectroscopy was used to assess the changes in E index (erythema) after overnight application of the pastes. In the first study, a total of 117 acne papules were assessed in 15 adolescents. Measurements of the E index were performed at 24-h intervals for 4 days on acne papules and the surrounding normal-looking skin. The last two assessments were performed the mornings preceding and following, respectively, a single application of the medicated paste. The second part of the study consisted of a double-blind, split-face study on 25 adolescents with acne. They applied each of the two formulations on a randomized part of the forehead. A total of 161 acne papules received the medicated paste and 160 received the same but unmedicated paste. Measurements were performed the mornings before and after the overnight treatment. RESULTS: In the first part of the study, no significant daily difference was observed between the three series of pretreatment E indices, on both acne papules and normal skin. The treatment did not affect the E index of normal skin. By contrast, it decreased significantly the E index of the acne papules. The second part of the study also showed that the medicated paste significantly decreased the E index of acne papules. This effect was significantly (P < 0.05) superior to that of the unmedicated paste. CONCLUSION: A single overnight application of miconazole nitrate paste appears to reduce the erythematous aspect of acne papules. [less ▲]

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See detailGranulomes à corps étrangers exogènes et endogènes
PIERARD, Gérald ULg; FLAGOTHIER, Caroline ULg; QUATRESOOZ, Pascale ULg et al

in Encyclopédie médico-chirurgicale Dermatologie (2005)

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See detailStigmates cutanés du diabète.
Flagothier, Caroline ULg; Quatresooz, Pascale ULg; Bourguignon, Raphaël et al

in Revue Médicale de Liège (2005), 60(5-6), 553-9

A number of relationships exist between diabetes mellitus and a series of cuteanous disorders. Skin lesions may reveal diabetes in a more or less specific way. They may also represent complications ... [more ▼]

A number of relationships exist between diabetes mellitus and a series of cuteanous disorders. Skin lesions may reveal diabetes in a more or less specific way. They may also represent complications supervening in an already treated diabetic patient. Some of these dermatoses (acanthosis nigricans, purpuric and pigmented capillaritis) are markers of macrovascular complications. The same disorders and some others (xerosis, Dupuytren's disease) are more frequently associated with microangiopathy in Type II diabetes. Other skin diseases (alopecia areata, vitiligo) are markers of auto-immunity in Type I diabetes. [less ▲]

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See detailLe médicament du mois. L'association calcipotriol-dipropionate de bétamethasone (dovobet).
Henry, Frédérique ULg; Flagothier, Caroline ULg; Delvoye, Pierre et al

in Revue Médicale de Liège (2005), 60(11), 893-5

The topical treatment of psoriasis benefits from the alternate use of dermocorticosteroids and vitamin D3 analogues. A new galenic formulation allows to combine them in a single application. Dovobet (LEO ... [more ▼]

The topical treatment of psoriasis benefits from the alternate use of dermocorticosteroids and vitamin D3 analogues. A new galenic formulation allows to combine them in a single application. Dovobet (LEO Pharma) ointment is the association of calcipotriol 50 microg/g with betamethasone dipoprionate 0.5 mg/g. This formulation boosts the therapeutic activity of calcipotriol. It also decreases the irritative inflammatory reaction due to calcipotriol without increasing the atrophogenic risk of the dermocorticoid. [less ▲]

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See detailNew insights into the effect of amorolfine nail lacquer.
Flagothier, Caroline ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Mycoses (2005), 48(2), 91-4

Despite improvements in antifungal strategies, the outcome of treating onychomycoses often remains uncertain. Several factors account for treatment failure, of which the pharmacokinetics and ... [more ▼]

Despite improvements in antifungal strategies, the outcome of treating onychomycoses often remains uncertain. Several factors account for treatment failure, of which the pharmacokinetics and pharmacodynamics of the antifungal are of importance. The taxonomic nature and ungual location of the fungus cannot be neglected, besides the type of nail and its growth rate. In addition, the biological cycle of the fungus and the metabolic activity of the pathogen likely play a marked influence in drug response. The presence of natural antimicrobial peptides in the nail is also probably a key feature controlling the cure rates. There are many outstanding publications that cover the full spectrum of the field. The purpose of this review is to put in perspective some facets of activity of the topical treatment using amorolfine nail laquer. The antifungal activity of the drug is likely less pronounced in onychomycosis than that expected from conventional in vitro studies. However, the nail laquer formulation should reduce the propensity to form antifungal-resistant spores and limit the risk of reinfection. [less ▲]

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See detailLa peau et ses nuances ethniques.
Flagothier, Caroline ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2005), 60 Suppl 1

Ethnic (racial) differences exist for a series of physiological skin characteristics. Colour is responsible for typology and resistance to ultraviolet irradiations. Other differences have also been ... [more ▼]

Ethnic (racial) differences exist for a series of physiological skin characteristics. Colour is responsible for typology and resistance to ultraviolet irradiations. Other differences have also been reported for the transepidermal water loss, the size and cohesion of corneocytes, the vascular reactiviy, the biomechanical properties, the pH, the lipidic content, the superficial microflora and the structure of mast cell granules. [less ▲]

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See detailLe lymphome T anaplasique CD30 positif cutané primitif, une affection au pronostic favorable.
Flagothier, Caroline ULg; Quatresooz, Pascale ULg; Franchimont, Claudine ULg et al

in Dermatologie Actualité (2004), 80

Le mycosis fongoïde représente le plus fréquent des lymphomes primitifs de la peau. Le syndrome de Sézary et les lymphomes T anaplasiques sont beaucoup plus rares. Malgré un aspect cytologique très ... [more ▼]

Le mycosis fongoïde représente le plus fréquent des lymphomes primitifs de la peau. Le syndrome de Sézary et les lymphomes T anaplasiques sont beaucoup plus rares. Malgré un aspect cytologique très atypique, le lymphome T anaplasique CD30 positif à localisation cutanée primitive est un lymphome de pronostic favorable. Une concertation et une prise en charge multidisciplinaire sont nécessaires afin d’éviter les écueils d’une thérapeutique résolument trop agressive. [less ▲]

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See detailBiocénose cutanée, peptides antimicrobiens cutanés et antiseptiques.
Flagothier, Caroline ULg; Uhoda, Emmanuelle ULg; Goffin, Véronique ULg et al

in Dermatologie Actualité (2004), 86

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See detailComment je traite...un psoriasis du cuir chevelu.
Uhoda, I.; Flagothier, Caroline ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2004), 59(9), 481-4

Scalp involvement by psoriasis requires a ted treatment suited to the particularities of the anatomical site In course of time, the improvement of therapeutic agents and the galenic refinement have ... [more ▼]

Scalp involvement by psoriasis requires a ted treatment suited to the particularities of the anatomical site In course of time, the improvement of therapeutic agents and the galenic refinement have enhanced both the efficacy and cosmetic acceptability of the scalp care. The main therapeutic classes encompass keratolytics, dermocorticosteroids and vitamine D3 analogues. The patient compliance is reported to be best for the liquid or foam formulations. [less ▲]

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See detailLes toxidermies paroxystiques graves.
Paquet, Philippe ULg; Flagothier, Caroline ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2004), 59(5), 286-92

Some drug reactions showing cutaneous expression exhibit a paroxysmal course. These diseases encompass the toxic epidermal necrolysis, the drug hypersensitivity syndrome, and the acute generalized ... [more ▼]

Some drug reactions showing cutaneous expression exhibit a paroxysmal course. These diseases encompass the toxic epidermal necrolysis, the drug hypersensitivity syndrome, and the acute generalized exanthematic pustulosis. These syndromes are associated with dismal outcome. They represent medical emergencies needing hospitalization in specialized care units. [less ▲]

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See detailLe cas clinique du mois. La syphilis, une MST de retour en nos murs.
Flagothier, Caroline ULg; Arrese Estrada, Jorge ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2004), 59(7-8), 426-9

Sexually transmitted diseases (STD) show frequent epidemiological changes. We report a case of secondary syphilis diagnosed in a 32-year old woman during post-partum. The disease, although showing a ... [more ▼]

Sexually transmitted diseases (STD) show frequent epidemiological changes. We report a case of secondary syphilis diagnosed in a 32-year old woman during post-partum. The disease, although showing a typical presentation, raises the problem of dating with precision the contamination time. This is of importance for treating the newborn at risk of congenital syphilis. We highlight the constant attention that should be brought to disclose this venereal disease that shows so variable clinical and histological presentations. Syphilis seems on the rise in the Mosan valley and in some cities where prostitution is imported from Eastern Europe and Africa. [less ▲]

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