References of "Ericsson, Anders"
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See detailThymus Gland, Neuroendocrinology
Geenen, Vincent ULg; Robert, Françoise; Ericsson, Anders et al

in Smith, Barry; Adelman, George (Eds.) The Neuroscience Year, Supplement 2 to the Encyclopedia of Neuroscience (1992)

T-cell differentiation occurs primarily within the thymus and is regulated through intimate intercellular contacts, interactions between major histocompatibility proteins and the T-cell receptor complex ... [more ▼]

T-cell differentiation occurs primarily within the thymus and is regulated through intimate intercellular contacts, interactions between major histocompatibility proteins and the T-cell receptor complex, as well as exchanges of peptide signals between immature lymphocytes and thymic environmental cellular populations. There is now ample evidence that neuropeptide-lymphocyte interactions occur at multiple levels in the thymus, and that the sources of neuropeptides are encountered in different sites such as thymic innervating fibers, stromal cells, and developing thymocytes themselves. An important question to consider is the fact that neuropeptides are intrinsic components of the 'self' molecular structure, and therefore may contribuye to the induction of T-cell self tolerance. After immature thymocytes have escaped the deletion process of clones highly reactive for 'self' peptides, thymic neuropeptides could also represent accessory signals for activation (or inhibition) steps in the developmental programme of the T-cell system. [less ▲]

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See detailExpression of preprotachykinin-A and neuropeptide-Y messenger RNA in the thymus
Ericsson, Anders; Geenen, Vincent ULg; Robert, François et al

in Molecular Endocrinology (1990), 4

The preprotachykinin-A gene, the common gene of mRNAs encoding both substance-P (SP) and neurokinin- A (NKA), was shown to be expressed in Sprague-Dawley rat thymus by detection of specific mRNA in gel ... [more ▼]

The preprotachykinin-A gene, the common gene of mRNAs encoding both substance-P (SP) and neurokinin- A (NKA), was shown to be expressed in Sprague-Dawley rat thymus by detection of specific mRNA in gel-blot analyses. In situ hybridization revealed dispersed PPT-A-labeled cells in sections from rat thymus, with a concentration of grains over a subpopulation of cells in the thymic medulla. Also, neuropeptide-Y mRNA-expressing cells were found in the rat thymus, primarily in the thymic medulla. Rat thymic extracts contained SP-like immunoreactivity (SP-LI), and the major part of the immunoreactivity coeluted with authentic SP and SP sulfoxide standards. SP-LI was also detected in human thymus, which contained between 0.09-0.88 ng SP-LI/ g wet wt. Evidence for translation of preprotachykinin- A mRNA in the rat thymus was obtained from the demonstration of NKA-LI in thymic cells with an epithelial-like cell morphology. Combined with previous observations on the immunoregulatory roles of tachykinin peptides and the existence of specific receptors on immunocompetent cells, the demonstration of intrathymic synthesis of NKA suggests a role for NKA-LI peptides in T-cell differentiation in the thymus. [less ▲]

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