  Effects of Alpha-Hederin, a Saponin Extracted from Hedera Helix, on Cells Cultured in Vitro; ; et al in Planta Medica (1994), 60(1), 45-9 In this work, we have analysed the effects of alpha-hederin, a monodesmosidic triterpenoid saponin isolated from Hedera helix, on mouse B16 melanoma cells and non-cancer mouse 3T3 fibroblasts cultured in ... [more ▼] In this work, we have analysed the effects of alpha-hederin, a monodesmosidic triterpenoid saponin isolated from Hedera helix, on mouse B16 melanoma cells and non-cancer mouse 3T3 fibroblasts cultured in vitro. Our results indicate that, in a serum-free medium, alpha-hederin is cytotoxic and inhibits proliferation in both cell lines at rather low concentrations (< 5 micrograms/ml) after only 8 hours of treatment. Its cytotoxicity decreases in the presence of serum in which BSA seems to be able to bind the saponin. alpha-Hederin also induces vacuolization of the cytoplasm and membrane alterations leading to cell death. [less ▲] Detailed reference viewed: 39 (0 ULg)Cytotoxic Activity of Some Triterpenoid Saponins; ; et al in Planta Medica (1992), 58 The present note deals with the cytotoxic activity of purified saponins of hedera helix and of saponins isolated from other plants ( Calendula officinalis, C. arvensis and Sapindus mukurossi with a view ... [more ▼] The present note deals with the cytotoxic activity of purified saponins of hedera helix and of saponins isolated from other plants ( Calendula officinalis, C. arvensis and Sapindus mukurossi with a view to the detection of possible structure-activity relationships. The most active compounds are the monodesmosides which show some degree of cytotoxicity at concentrations of 10 micrograms/ml and above. Among them, alpha- and beta-hederin are the most potent substances. [less ▲] Detailed reference viewed: 58 (0 ULg) |
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