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See detailHERPES SIMPLEX VIRUS REACTIVATION AND DENTAL PROCEDURES
EL HAYDERI, Lara ULg; DELVENNE, Philippe ULg; ROMPEN, Eric ULg et al

in Clinical Oral Investigations (2013)

Objectives : Dental extraction is reportes to trigger recurrent herpes labialis (RHL). Aim : This aims to prospectively study the clinical occurrence of RHL and the oral herpes simplex virus type 1 (HSV-1 ... [more ▼]

Objectives : Dental extraction is reportes to trigger recurrent herpes labialis (RHL). Aim : This aims to prospectively study the clinical occurrence of RHL and the oral herpes simplex virus type 1 (HSV-1) viral shedding before and 3 days after different dental procedures. Materials and methods : Oral HSV-1 DNA was measured by real-time PCR before and 3 days after dental procedures of the inferior dentition in 57 immunocometent patients (mean age 32.4 years) who were selected and divided into four distinct subgroups (dental inspection without anesthesia, n=14; molar extraction under local anesthesia, n=15; and molar extraction under general anesthesia, n=9) and compared to 32 healthy controls (mean age 33 years). Results : None of the patients suffered from RHL at day 3. Oral HSV-1 DNA was detected before and after procedure in 1.7 % (1/57) and 5.3 % (3/57), respectively [dental inspection without anesthesia, 5.3 % (1/19); molar extraction under local anesthesia, 6.7 % (1/15); and molar extraction under general anesthesia, 11 % (1/9)]. None of the controls presented RHL or detectable oral HSV-1 DNA. There was no statistically significant difference between the study groups and controls. [less ▲]

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See detailHair Loss after Varicella Zoster Virus
EL HAYDERI, Lara ULg; NIKKELS, Nazli ULg; Nikkels, Arjen ULg

in Case Reports in Dermatology (2013)

Varicella zoster virus (VZV) cutaneous infection occurs predominantly in epidermal and infundibular keratinocytes and accessorily in dermal dendritic cells. These latter cells play a role in cicatricial ... [more ▼]

Varicella zoster virus (VZV) cutaneous infection occurs predominantly in epidermal and infundibular keratinocytes and accessorily in dermal dendritic cells. These latter cells play a role in cicatricial processes. Two patients are presented with localized alopecia after VZV infection. A 4-year-old girl presented localized hair loss affecting about 20% of her upper right eyelash immediately following the resolution of the varicella skin lesions. No regrowth was observed after 3 months. An 80-year-old woman with a prior history of localized alopecia areata of the left occipital area presented severe left herpes zoster affecting the V1 and V2 dermatomes. At precisely the same site of the previous episode, a localized plaque of alopecia areata recurred. After topical corticosteroid therapy, a progressive hair regrowth occurred after about 3 months. These case reports are the first relating cutaneous VZV infection as the origin for permanent cicatricial alopecia and transitory alopecia areata. Localized hair loss should be added to the cutaneous complications of VZV skin infection. [less ▲]

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See detailHERPES SIMPLEX VIRUS TYPE_i AND PYOGENIC GRANULOMA : A VASCULAR ENDOTHELIAL GROWTH FACTOR-MEDIATED ASSOCIATION?
EL HAYDERI, Lara ULg; PAUROBALLY, Dilshad ULg; FASSOTTE, Marie-France ULg et al

in Case Reports in Dermatology (2013), 5

Pyogenic granuloma (PG) is a vascular endothelial growth factor (VEGF)-related neoangiogenic process. Minor trauma, chronic irritation, certain drugs and pregnancy may favor PG. Viral triggers have not ... [more ▼]

Pyogenic granuloma (PG) is a vascular endothelial growth factor (VEGF)-related neoangiogenic process. Minor trauma, chronic irritation, certain drugs and pregnancy may favor PG. Viral triggers have not been reported up to date. A 52-year-old woman with hairly-cell leukemia presented because of a3-month history of a giant pseudotumoral lesion on her left cheek. All prior antibacterial, antifungal and anti-inflammatory treatments had failed. Histology revealed PG with sparse and isolated epithelial cell aggregates. Immunohistochemistry (IHC) identified herpes simplex virus type-I (HSV-I) antigens in the nuclei and cytoplasm of normal-appearing as well as cytopathic epithelial cells, suggesting a chronic, low-productive HSV infection. No HSV-I signal was evidenced in the endothelial cells of the PG. Furthermore, IHC revealed VEGF in the HSV-I infected epithelial cells as well as within the PG endothelial cells. These results incited oral treatment with valaciclovir, and the PG promptly resolved after 2 weeks. These findings suggest that a chronic HSV-I infection might play and indirect, partial role in neoangiogenesis, presumably via HSV-I infection-related stimulation of keratinocytic VEGF production. [less ▲]

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See detailDermatological manifestations of varicella
EL HAYDERI, Lara ULg; NIKKELS, Arjen ULg

in Advances in Medicine and Biology (2013), 67

The Varicella zoster virus (VZV) is responsible for chickenpox and herpes zoster (HZ). VZV displays neuro- and epidermotropism, although other cells lines may be infected. A permissive type of VZV ... [more ▼]

The Varicella zoster virus (VZV) is responsible for chickenpox and herpes zoster (HZ). VZV displays neuro- and epidermotropism, although other cells lines may be infected. A permissive type of VZV infection in the epidermal and/or infundibular keratinocytes forms the majority of the skin lesions. This infections leads to intra-epidermal blistering, clinically characterized by vesicular lesions. During varicella, the haematogenous dissemination of VZV virions infects the dermal endothelial cells, which in their turn infect dermal dendrocytes who transport he virions to the keratinocytes of the basal layer. During HZ, the VZV virions arrive in the keratinocytes after release by the free nerve endings in close contact with the basal keratinocytes. The skin-associated immune system (SALT) furthermore determines the outcome of the virus/host cell relation. The spectrum of the VZV-related skin infections is presented with their pathogenic mechanisms, including lichenoid HZ, granulomatous HZ, verrucous HZ and follicular HZ. It is important to be aware of these manifestations of the VZV, in particular as VZV may present serious morbidity int eh immunocompromised patient. [less ▲]

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See detailSeasonal variations in vitamin D levels in melanoma patients: a single-centre prospective pilot comparative study
FAILLA, Valérie ULg; CAVALIER, Etienne ULg; EL HAYDERI, Lara ULg et al

in Journal of the European Academy of Dermatology & Venereology (2012), 26(5), 651-3

BACKGROUND: More than 90% of vitamin D synthesis is dependent on UV exposure. Photosensitive disorders such as lupus erythematosus, protoporphyria and xeroderma require strict sun avoidance, and vitamin D ... [more ▼]

BACKGROUND: More than 90% of vitamin D synthesis is dependent on UV exposure. Photosensitive disorders such as lupus erythematosus, protoporphyria and xeroderma require strict sun avoidance, and vitamin D deficiency has been demonstrated in these patients. Melanoma patients are also instructed to avoid sun exposure and may hence be expected to be vitamin D deficient. MATERIALS AND METHODS: Winter and summer vitamin D levels were compared in a group of melanoma patients (n =61) and age- and phototype-matched controls (n = 53) without photosensitive disorders. RESULTS: Oral supplementary vitamin D intake was reported in 32.7% of the melanoma patients and in 15.1% in the control group. Despite oral supplementation, only 25% of the melanoma patients and the controls presented with vitamin D levels of 30 ng/mL or higher. In non-supplemented subjects in the melanoma and control groups, respectively, mean winter vitamin D levels were below the recommended threshold at 12.6 ng/mL vs. 13.2 ng/mL, respectively, but not statistically different. These values increased significantly in both groups during the summer to 24.6 and 23.8 ng/mL respectively. CONCLUSION: Unexpected, significant increases in vitamin D levels were seen in melanoma patients during summer, suggesting non-adherence with photoprotective measures and reflecting a heliophilic behaviour. Vitamin D supplementation is recommended in melanoma patients during both winter and summer. [less ▲]

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See detailLe vemurafenib, une avancée majeure dans le traitement du mélanome métastatique exprimant le BRAF V600E
EL HAYDERI, Lara ULg; RORIVE, Andrée ULg; NIKKELS, Arjen ULg

in Skin Inc (2012)

Malgré une sensibilisation de la population concernant les dangers du soleil, des techniques diagnostiques très sensibles comme la dermoscopie et une diminution constante de l'épaisseur des mélanomes lors ... [more ▼]

Malgré une sensibilisation de la population concernant les dangers du soleil, des techniques diagnostiques très sensibles comme la dermoscopie et une diminution constante de l'épaisseur des mélanomes lors du premier diagnostic, il existe toujours des cas où le diagnostic arrive trop tard. Le pronostic du mélanome métastatique (stade IV) reste alors péjoratif avec une survie n'excédant pas les 5% à 5 ans. Les traitements par agents chimiothérapeutiques comme le DTIC (dacarbazine), les immunothérapies comme l'interféron ou les vaccinations à base de cellules dendritiques ne donnent que très peu d'espoir dans cette indication. Heureusement, des avancées significatives sont rapportées dans le traitement du mélanome métastatique exprimant la mutation BRAF V600E avec un inhibiteur de la BRAF kinase, le vemurafinib. Les résultats d'une étude de phase III montrent une diminution de 63 % du risque de décès et de 74 % du risque de progression avec le vemurafenib, par rapport à la chimiothérapie par DTIC. Le vemurafenib est associé à de nombreux effets indésirables cutanés (rash, alopécie, kérato-acanthome, carcinomes spinocellulaires, photosensibilité ...), qu'il est important de reconnaître pour pouvoir assurer une prise en charge thérapeutique adéquate. [less ▲]

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See detailHerpes Simplex Virus Infections of the Nipple
EL HAYDERI, Lara ULg; CAUCANAS, Marie ULg; NIKKELS, Arjen ULg

in Open Dermatology Journal (The) (2012)

The usual sites of herpes simplex virus (HSV) type 1 and 2 infections are orolabial and anogenital, respectiverly. HSV infection of the nipple and periareolar area is exceptional but probably ... [more ▼]

The usual sites of herpes simplex virus (HSV) type 1 and 2 infections are orolabial and anogenital, respectiverly. HSV infection of the nipple and periareolar area is exceptional but probably underrecognized. Typical features include severe pain and erosive or ulcerated erythematous confluent clusters of lesions of the nipple and periareolar area. It is usually unilateral and not recurring. HSV infection of the nipple is originating from autoinoculation, sexual transmission or breastfeeding. Diagnosis is often delayed. The Tzanck smear is the most rapid and adequate method of dagnosis. Immunohistochemistry enables viral identification. The treatment relies on topical disinfection and oral antiviral therapy, such as aciclovir, famciclovir or valaciclovir. Scarring is uncommon. [less ▲]

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See detailCOMPLICATIONS DERMATOLOGIQUES DES TATOUAGES DEFINITIFS ET TEMPORAIRES
CAUCANAS, MARIE; EL HAYDERI, Lara ULg; LEBAS, Eglantine ULg et al

in Annales de Dermatologie et de Vénéréologie (2011)

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See detailSeasonal variations in vitamin D levels in melanoma patients : a single-centre prospective pilot comparative study
FAILLA, Valérie ULg; CAVALIER, Etienne ULg; EL HAYDERI, Lara ULg et al

in Journal of the European Academy of Dermatology & Venereology (2011)

Background: More than 90% of vitamin D synthesis is dependent on UV exposure. Photosensitive disorders such as lupus erythematosus, protoporphyria and xeroderma require strict sun avoidance, and vitamin D ... [more ▼]

Background: More than 90% of vitamin D synthesis is dependent on UV exposure. Photosensitive disorders such as lupus erythematosus, protoporphyria and xeroderma require strict sun avoidance, and vitamin D deficiency has been demonstrated in these patients. Melanoma patients are also instructed to avoid sun exposure and may hence be expected to be vitamin D deficient. Materials and method : Winter and summer vitamin D levels were compared in a group of melanoma patients (n=61) and age- and phototype-matched controls (n=53) without photosensitive disorders. Results : Oral supplementary vitamin D intake was reported in 32.7% of the melanoma patients and in 15.1 % in the control group. Despite oral supplementation, only 25% of the melanoma patients and the controls presented with vitamin D levels of 30 ng/mL or higher. In non-supplemented subjects in the melanoma and control groups, respectively, mean winter vitamin D levels were below the recommended threshold at 12,6 ng/mL vs 13.2 ng/mL, respectively, but not statistically different. These values increased significantly in both groups during the summer to 24.6 and 23.8 ng/mL respectively. Conclusion: Unexpected, significant increases in vitamin D levels were seen in melanoma patients during summer, suggesting non-adherence with photoprotective measures and reflecting a heliophilic behaviour. Vitamin D supplementation is recommended in melanoma patients during both winter and summer. [less ▲]

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See detailOccurence familiale du syndrome de Leser-Trélat
EL HAYDERI, Lara ULg; NIKKELS, Arjen ULg

in Skin Inc (2010)

L'existence du syndrome de Leser-Trélat (SLT), defini comme l'apparition rapide

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See detailSevere herpes simplex virus type-I infections after dental procedures
EL HAYDERI, Lara ULg; RATY, Laurent ULg; FAILLA, Valérie ULg et al

in Oral Surgery, Oral Medicine, and Oral Pathology (2010)

Background : Reccurences of herpes labialis (RHL) may be triggered by systemic factors, including stress, menses, and fever. Local stimuli, such as lip injury or sunlight exposure are also associated to ... [more ▼]

Background : Reccurences of herpes labialis (RHL) may be triggered by systemic factors, including stress, menses, and fever. Local stimuli, such as lip injury or sunlight exposure are also associated to RHL. Dental extraction has also been reported as triggering event. Case report : Seven otherwise healthy patients are presented with severe and extensive RHL occuring about 2-3 days after dental extraction under local anaesthesia. Immunohistochemistry on smears and immunofluorescence on cell culture identified herpes simplex virus type I (HSV-I). Five patients reported more severe prodromal signs than usual. Although all the patients suffered from RHL, non had previously experienced RHL after dental care. Two patients required hospitalisation for intravenous acyclovir therapy, whereas the others were successfully treated with oral valaciclovir or acyclovir. Conclusion : Severe and extensive RHL can occur soon after dental extraction under local anaesthesia. Patients a with previous history of RHL seem to be at higher risk. It is not clear whether RHL is linked to the procedure itself, to the anaesthetic procedure or both. As the incidence is unknown, more studies are required to recommend prophylactif antiviral treatment in RHL patients who are undergoing extractions. Dentists should be aware of this potentially servere post-extraction complication. [less ▲]

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See detailLe syndrome de la traversée cervico-thoraco-brachiale : une lourde hérédité anatomique
CARLIER, Alain ULg; Ronsmans, C; BRILMAKER, Julien ULg et al

in e-mémoires de l'Académie Nationale de Chirurgie (2008), 7(3), 49-55

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