References of "Dupuis, Marie-Capucine"
     in
Bookmark and Share    
Full Text
See detailGénétique de la neuropathie laryngée récurrente chez le cheval
Dupuis, Marie-Capucine ULg

Doctoral thesis (2011)

Recurrent laryngeal neuropathy (RLN), known as « roaring » or « whistling », has been considered as the most important equine airway disease of the horse. It can cause abnormal respiratory noise during ... [more ▼]

Recurrent laryngeal neuropathy (RLN), known as « roaring » or « whistling », has been considered as the most important equine airway disease of the horse. It can cause abnormal respiratory noise during fast exercise, secondary to a reduced abduction of the left arytenoid cartilage, which may impair performance. Despite significant research into the disease, some aspects, such as etiology and pathogenesis, remain unknown. Several papers suggest a genetic basis but molecular studies have never been reported. Using the EquineSNP50 Beadchip, we genotyped 234 cases (196 Warmbloods, 20 Trotters, 14 Thoroughbreds and 4 Draft Horses), 228 breed-matched controls and 69 parents. Linkage disequilibrium and population structure were quantified before performing single marker and haplotype-based association studies, as well as family-based linkage analyses. Two genome-wide suggestive loci were identified on chromosomes 21 and 31, driven by the enrichment of a “protective” haplotype in controls compared to cases. Our study indicates that predisposition to RLN has a complex determinism, probably involving a high number of genes, of which the candidates on chromosome 21 and 31 may have the largest effects. We performed a copy-number variants analysis on the same data. After characterization of the regions harbouring these variants, an association study with RLN was conducted. A duplication on chromosome 10 was identified in ten affected horses and two unphenotyped parents that were sharing a long haplotype. This work provides novel insights in the genetic determinism of NLR and opens new field of research. If the genuine nature of these loci is confirmed in independent cohorts, identifying the causative genes may increase our understanding of RLN pathogenesis. Assuming that RLN is very polygenic, predictive diagnosis and selection may be more effective using a genomic selection type of approach. [less ▲]

Detailed reference viewed: 34 (13 ULg)
Full Text
Peer Reviewed
See detailResults of a haplotype-based GWAS for recurrent laryngeal neuropathy in the horse.
Dupuis, Marie-Capucine ULg; Zhang, Zhiyan ULg; Druet, Tom ULg et al

in Mammalian Genome : Official Journal of the International Mammalian Genome Society (2011)

Recurrent laryngeal neuropathy (RLN) is a major upper-airway disease of horses that causes abnormal respiratory noise during exercise and can impair performance. Etiopathogenesis remains unclear but ... [more ▼]

Recurrent laryngeal neuropathy (RLN) is a major upper-airway disease of horses that causes abnormal respiratory noise during exercise and can impair performance. Etiopathogenesis remains unclear but genetic factors have been suspected for many decades. The objective of this study was to identify risk loci associated with RLN. To that end we genotyped 234 cases (196 Warmbloods, 20 Trotters, 14 Thoroughbreds, and 4 Draft horses), 228 breed-matched controls, and 69 parents with the Illumina Equine SNP50 BeadChip. Using these data, we quantified population structure and performed single-marker and haplotype-based association studies, as well as family-based linkage analyses. We accounted for population stratification by modeling a random polygenic background effect with covariance structure estimated from genome-wide SNP data. Using the haplotype-based approach, we identified two genome-wide suggestive loci in Warmbloods, respectively on chromosomes 21 (p = 1.62 x 10(-6)) and 31 (p = 1.69 x 10(-5)). The two signals were driven by the enrichment of a "protective" haplotype in controls compared to cases. [less ▲]

Detailed reference viewed: 29 (10 ULg)
Full Text
Peer Reviewed
See detailSubclinical diseases affecting performance in Standardbred trotters: Diagnostic methods and predictive parameters
Richard, Eric ULg; Fortier, Guillaume; Pitel, Pierre-Hugues et al

in Veterinary Journal (2010), 184(3), 282-289

The objectives of this study were to determine the prevalence of sub-clinical diseases in poorly-performing Standardbred horses, compare their physiological response to exercise with control horses, and ... [more ▼]

The objectives of this study were to determine the prevalence of sub-clinical diseases in poorly-performing Standardbred horses, compare their physiological response to exercise with control horses, and identify predictive parameters of poor-performance. Fifty horses underwent thorough clinical and ancillary examinations, including haematological and biochemical evaluation, Doppler echocardiography, standardised exercise tests (SETs) on both treadmill and racetrack, treadmill video-endoscopy and collection of respiratory fluids. Most of the poorly-performing horses exhibited many concomitant diseases. The most frequently diagnosed problems involved the lower and upper respiratory tract and the musculoskeletal system. Poor-performers had lower speeds at a blood lactate (LA) concentration of 4 mmol/L (VLA4) and a heart rate (HR) of 200 bpm (V200) on treadmill and racetrack, as well as lower values for haematological parameters, plasma angiotensin-converting enzyme and antioxidants, compared to control horses. Problems of the respiratory system were the most frequently diagnosed sub-clinical diseases affecting performance. SETs, together with some blood markers, may be useful as a non-specific diagnostic tool for early detection of diseases that may affect performance. [less ▲]

Detailed reference viewed: 100 (16 ULg)
Full Text
Peer Reviewed
See detailEndoscopie à l'effort : les examens sur piste et sur tapis roulant sont-ils équivalents ?
Van Erck, Emmanuelle ULg; Frippiat, Thibault ULg; Dupuis, Marie-Capucine ULg et al

in Proceedings des Journées annuelles de l’Association vétérinaire équine française (2009) (2009, October)

Detailed reference viewed: 65 (11 ULg)
Full Text
Peer Reviewed
See detailSyndrome d'inflammation trachéale : évaluation clinique et bactériologique
Richard, Eric ULg; Maillard, K.; Dupuis, Marie-Capucine ULg et al

in Pratique Vétérinaire Equine (2009), 41(162), 45-49

Lower airway inflammation is a frequent cause of poor-performance in hors e s .An association between inflammation and bacterial isolation in tracheal wash fluid has previously been found ; bacterial ... [more ▼]

Lower airway inflammation is a frequent cause of poor-performance in hors e s .An association between inflammation and bacterial isolation in tracheal wash fluid has previously been found ; bacterial counts were neve rtheless not defined.The aims of this study were to qualitatively and quantitatively compare tracheal bacterial flora of French Trotters with tracheal inflammation (SIT) and control horses (CTL), and evaluate association between endoscopic, cytological and microbiological evaluation of the trachea. Neutrophil percentage in tracheal wash was significantly different between groups whereas tracheal mucus accumulation was not. No significant difference was found between groups for neither percentage of respectively sterile samples or percentage pathogenic bacteria being isolated. Bacterial counts in SIT group were however 10 to 200 times higher than in the CTL group.This study suggests that isolation of pathogenic bacteria alone do not allow estimation of the level of airway inflammation; whereas severe tracheal inflammation may be present in absence of any bacteriological infection [less ▲]

Detailed reference viewed: 317 (16 ULg)
Full Text
Peer Reviewed
See detailUpper airway dynamic endoscopy: are track and treadmill observations comparable ?
Van Erck, Emmanuelle ULg; Frippiat, Thibault ULg; Dupuis, Marie-Capucine ULg et al

in Tessier, Caroline; Gerber, Vincent (Eds.) Abstract book: 4th World Equine Airways Symposium (WEAS) (2009)

Detailed reference viewed: 170 (26 ULg)
Full Text
Peer Reviewed
See detailAssociation between inflammatory airway disease, tracheal inflammation and respiratory function evaluated by impulse oscillometry
Richard, Eric ULg; Fortier, G.; Dupuis, Marie-Capucine ULg et al

in Tessier, Caroline; Gerber, Vincent (Eds.) Abstract book: 4th World Equine Airways Symposium (WEAS) (2009)

Detailed reference viewed: 31 (6 ULg)