New Alkoxypyridine-sulfonamides: synthesis, biological evaluation and physicochemical properties

in Helvetica Chimica Acta (1991), 74(8), 1764-1772

Revision of the Structure of Strychnochromine

in Tetrahedron Letters (1991), 32(34), 4295-4298

The structure of strychnochromine, an unusual alkaloid isolated from a new batch of the root bark of Strychnos gossweileri has been revised . To confirm the indoline structure ( proposed in 1988) and to ... [more ▼]

The structure of strychnochromine, an unusual alkaloid isolated from a new batch of the root bark of Strychnos gossweileri has been revised . To confirm the indoline structure ( proposed in 1988) and to establish the stereochemistry of the compound extensive 2D-NMR experiments were carried out. The COSY experiments mostly confirmed the previous observations but the COLOC maps did not fit the first proposed structure!The problem was solved by single-crystal X-ray analysis of the p-bromobenzoyl ester of strychnochromine. The new structure, with its tetrahydroquinoline ring, is very unusual in Strychnos species but the formation of quinolines from indole alkaloids has already mentioned in some other plants ( Cinchona, Alstonia, Hunteria..). [less ▲]

Acide cyclohexyl-4 naphtalène-1-propionique

in Acta Crystallographica. Section B-Structural Crystallography and Crystal Chemistry (1982), 38(9), 2409-2411

Torasemide: a comparison of two refinement computer programs and effects on CNDO/2 calculations

in Extrait du Bulletin de la Société Royale des Sciences de Liège (1982), 5-8

The 4.5 A resolution structure analysis of the exocellular DD-carboxypeptidase of Streptomyces albus G.

in FEBS Letters (1980), 117(1), 212-214

Isolation and structure of sungucine, a new type of bisindoline alkaloid

in Tetrahedron Letters (1979), (43), 4227-4228

From the roots of Strychnos icaja BAILLON, an unsymmetrical dimeric alkaloid has been isolated and called sungucine. Its original structure has been established by X-Ray diffraction; UV,IR,MS and NMR data ... [more ▼]

From the roots of Strychnos icaja BAILLON, an unsymmetrical dimeric alkaloid has been isolated and called sungucine. Its original structure has been established by X-Ray diffraction; UV,IR,MS and NMR data are also given. [less ▲]

Structure Cristalline et Moléculaire de la Picrotoxine, C15H16O6.C15H18O7

in Acta Crystallographica. Section B-Structural Crystallography and Crystal Chemistry (1976), B32(11), 2987-2993

Picrotoxin is the toxic constituent of Anamirta cocculus fruits. Crystals of picrotoxin are monoclinic and are an addition component of two almost identical molecules :picrotoxinin, C15H16O6, and picrotin ... [more ▼]

Picrotoxin is the toxic constituent of Anamirta cocculus fruits. Crystals of picrotoxin are monoclinic and are an addition component of two almost identical molecules :picrotoxinin, C15H16O6, and picrotin, C15H18O7.The structure of each molecule is compared with the crystal structure of alpha1-bromopicrotoxinin. [less ▲]

Détermination de la Structure Cristalline et de la Configuration Absolue du Bromhydrate d'Usambarensine

in Acta Crystallographica. Section B-Structural Crystallography and Crystal Chemistry (1975), B31(6), 1571-1575

Usambarensine is a bisindolinic alkaloid found in the bark of Strychnos usambarensis roots. The crystal and molecular structure of usambarensine.2HBr.2H2O has been solved by direct methods thanks to a ... [more ▼]

Usambarensine is a bisindolinic alkaloid found in the bark of Strychnos usambarensis roots. The crystal and molecular structure of usambarensine.2HBr.2H2O has been solved by direct methods thanks to a Hilger-Watts four-circle diffractometer. The crystals are monoclinic; refinement of the parameters was carried out with 2459 reflexions. The absolute configuration of the molecule, determined by X-ray anomalous scattering, confirms the 3 alpha cis configuration ( 11alpha cis, IUPAC) assigned earlier by spectral, chromatographic and biogenetic data.This configuration seems dependent on the presence of an ethylidenic chain in the corynane part of the molecule. [less ▲]