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See detailCrystal structure of 7-chloro-3-isopropylsulfanyl-4H-1,2,4-benzothiadiazine 1,1-dioxide, C10H11CIN2O2S2
Dupont, L.; Boverie, S.; De Tullio, Pascal ULg et al

in Zeitschrift für Kristallographie. New Crystal Structures (2005), NCS 220

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See detailCrystal structure of 7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide, C10H12CIN3O2S
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg

in Zeitschrift für Kristallographie. New Crystal Structures (2005), NCS 220

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See detailCrystal structure of 7-chloro-3-isopropoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide monohydrate, C10H13CIN2O4S H2O
Dupont, L.; Boverie, S.; Pirotte, Bernard ULg et al

in Zeitschrift für Kristallographie. New Crystal Structures (2005), NCS 220

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See detail3-Isopropylamino-7-nitro-1,4,2-benzodithiazine 1,1-dioxide
Dupont, L.; Somers, F.; De Tullio, Pascal ULg et al

in Acta Crystallographica (2003)

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See detailOriginal 2-alkylamino-6-halogenoquinazolin-4(3H)-ones and KATP channel activity
Somers, F.; Ouedraogo, R.; Antoine, M.-H. et al

in Journal of Medicinal Chemistry (2001), 44

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See detail7-Chloro-2-methyl-3-methylamino-2H-1,2,4-benzothiadiazine 1,1-dioxide
Dupont, L.; Somers, F.; Boverie, S. et al

in Acta Crystallographica (2001), E57

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See detail3-Amino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxide
Dupont, L.; De Tullio, Pascal ULg; Boverie, S. et al

in Acta Crystallographica (2001), E57

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See detail(R/S)-3-(3-Methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide mono-hydrate
Dupont, L.; De Tullio, Pascal ULg; Tinant, B. et al

in Acta Crystallographica (2001), E57

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See detailAbsolute configuration of N-[(R)-3-methyl-2-butyl]-(S)-2-(6-methoxy-2-naphthyl)-propionamide
Dupont, L.; Khellili, S.; Pirotte, Bernard ULg et al

in Acta Crystallographica (2001), E57

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See detailPreparation and pharmacological evaluation of the R- and S-enantiomers of 3-(2’-butylamino)-4H- and 3-(3’-methyl-2’-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide, two tissue selective ATP-sensitive potassium channel openers
Khelili, S.; De Tullio, Pascal ULg; Lebrun, P. et al

in Bioorganic & Medicinal Chemistry (1999), 7(8), 1513-1520

The preparation and the pharmacological evaluation of the R- and S-isomers of 3-(2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 42) and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4 ... [more ▼]

The preparation and the pharmacological evaluation of the R- and S-isomers of 3-(2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 42) and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 44), two potassium channel openers, is described. Their optical purity was estimated by means of capillary electrophoresis (R- and S-BPDZ 42) and chiral HPLC (R- and S-BPDZ 44). The absolute configuration of each isomer of BPDZ 44 was deduced from crystallographic data. Pharmacological assays performed with the R- and S-isomers of BPDZ 44 revealed only slight differences in their activity on pancreatic B-cells but significant differences in their activity on vascular smooth muscle cells: the R-isomer being sixfold more potent than its corresponding S-isomer. The R-isomer of BPDZ 42 was shown to be more potent than its corresponding S-isomer on the endocrine pancreas. S-BPDZ 44 as well as R- and S-BPDZ 42 were found to exhibit tissue selectivity for the pancreatic versus the vascular smooth muscle tissue. [less ▲]

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See detail7-Iodo-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg

in Acta Crystallographica (1999), C55

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See detail4-Ethyl-2,3-dihydro-4H-pyrido[3,2-e]-1,2,4-thiadiazine 1,1-dioxide and 4-ethyl-2,3-dihydro-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide
Dupont, L.; Pirotte, Bernard ULg; Podona, T. et al

in Acta Crystallographica (1999), C55

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See detail3-Alkylamino-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as potent KATP-channel activators: structural study and influence of stereochemistry
De Tullio, Pascal ULg; Khelili, S.; Ouedraogo, R. et al

in Pharmacy and Pharmacology Communications (1999), 5

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