The impact of complete revascularization on long-term survival is strongly dependent on age

in Annals of Thoracic Surgery (2012), 94(4), 1166-1172

Cultural tourism in European Cities: Towards a strategic planning approach

in Proc. of the conference Life in the Urban Landscape (2005)

Oral monthly ibandronate is well tolerated and efficacious in postmenopausal women: results from the monthly oral pilot study (MOPS)

in Osteoporosis International (2004, May), 15(Suppl.1), 105-106

Low TSH requirement and goiter in transgenic mice overexpressing IGF-1 and IGF-1R in the thyroid gland

in Endocrinology (2001), 142(12), 5131-5139

Through the cAMP signaling pathway, TSH stimulates thyroid follicular cell proliferation, differentiation, and function. Although the autocrine production of IGF-I in the thyroid gland suggests an ... [more ▼]

Through the cAMP signaling pathway, TSH stimulates thyroid follicular cell proliferation, differentiation, and function. Although the autocrine production of IGF-I in the thyroid gland suggests an important physiological function for this factor in these processes, the exact role of the IGF-I/IGF-I receptor system in vivo remains unclear. Although the mitogenic action of TSH requires the presence of IGF-I or insulin in primary culture of dog and human thyroid cells, IGF-I has an effect equal to and independent of the effect of TSH on cell proliferation in rat thyroid cell lines and may even be the main growth regulator in this case. To investigate the in vivo function of the IGF-I/IGF-I receptor system, transgenic mice overexpressing human IGF-I, IGF-I receptor, or both in the thyroid were generated. Adult transgenic mice did not present external signs of thyroid dysfunction, but mice overexpressing both transgenes had significantly increased gland weight and follicular lumen area. A decreased TSH level together with a slightly increased serum T4 concentration and increased thyroidal iodine uptake were also observed, suggesting that IGF-I and IGF-I receptor stimulate thyroid function to some extent in vivo [less ▲]