References of "Dujardin, Marc"
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See detailA stepwise approach for chemical risks assessment at the workplace
Mairiaux, Philippe ULg; Balsat, Alain; Dujardin, Marc ULg et al

in Strasser, H.; Kluth, K.; Rausch, H. (Eds.) et al Quality of work and products in enterprises of the future (2003)

Detailed reference viewed: 15 (2 ULg)
Peer Reviewed
See detailSma Circuits Reduce Platelet Consumption and Platelet Factor Release During Cardiac Surgery
Defraigne, Jean-Olivier ULg; Pincemail, Joël ULg; Dekoster, Guy ULg et al

in Annals of Thoracic Surgery (2000), 70(6), 2075-81

BACKGROUND: Platelet count and function are particularly damaged by cardiopulmonary bypass (CPB). This study evaluated the effects of a novel CPB circuit in terms of platelet count and activation, and ... [more ▼]

BACKGROUND: Platelet count and function are particularly damaged by cardiopulmonary bypass (CPB). This study evaluated the effects of a novel CPB circuit in terms of platelet count and activation, and postoperative need for blood products. METHODS: One hundred patients undergoing coronary grafting were randomized in two groups: control group (n = 50) and test group (n = 50, surface modifying additives circuit, SMA group). Blood samples were taken before, during, and after CPB. Postoperative blood loss, number of transfused blood products, and postoperative variables were recorded. RESULTS: The platelet count decreased less in the SMA group compared to the control group (end of CPB: respectively, 165 +/- 9 x 10(3)/mm3 vs 137 +/- 8 x 10(3)/mm3; p < 0.01). This was paralleled by a reduction in beta-thromboglobulin plasma levels in the SMA group. There was a trend to decreased blood loss in the SMA group, but the difference was significant only in patients taking aspirin preoperatively (p < 0.05). In the SMA group nearly 50% less fresh frozen plasma and platelet units were administered (p < 0.01). No operative deaths were observed. CONCLUSIONS: The use of circuits with surface additives is clinically safe, preserves platelet levels, and attenuates platelet activation. This may lead to a reduced need for blood products. [less ▲]

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