References of "Dubuc, JE"
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See detailProtective effect of a new CHITOSAN BIOMATERIAL against the development of experimental osteoarthritis lesions in rabbit
Oprenyeszk, Frédéric ULg; Chausson, M; Maquet, V et al

Conference (2013, November 23)

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See detailCharacterization of synovial angiogenesis in osteoarthritis patients and its modulation by chondroitin sulfate
Lambert, Cécile ULg; Mathy-Hartert, Marianne; Dubuc, JE et al

in Arthritis Research & Therapy (2012), 14(2), 58

INTRODUCTION: This work aimed at comparing the production of inflammatory and pro- and anti-angiogenic factors by normal/reactive (N/R) or inflammatory (I) areas of the osteoarthritic synovial membrane ... [more ▼]

INTRODUCTION: This work aimed at comparing the production of inflammatory and pro- and anti-angiogenic factors by normal/reactive (N/R) or inflammatory (I) areas of the osteoarthritic synovial membrane. The effects of interleukin (IL)-1β and chondroitin sulfate (CS) on the expression of pro- and anti-angiogenic factors by synovial fibroblasts cells (SFC) were also studied. METHODS: Biopsies from N/R or from I areas of osteoarthritic synovial membrane were collected at the time of surgery. The inflammatory status of the synovial membrane was characterized by the surgeon according to macroscopic criteria, including the synovial vascularization, the villi formation and the hypertrophic aspect of the tissue. We assessed the expression of CD45, von Willebrand factor and vascular endothelial growth factor (VEGF) antigen by immunohistochemistry in both N/R and I biopsies. The production of IL-6, -8, VEGF and thrombospondin (TSP)-1 by N/R or I synovial cells was quantified by ELISA. SFC were cultured in the absence or in the presence of IL-1β (1 ng/ml) and with or without CS (10, 50, 200 μg/ml). Gene expression of pro-angiogenic factors (VEGF, basic fibroblast growth factor (bFGF), nerve growth factor (NGF), matrix metalloproteinase (MMP)-2 and angiopoietin (ang)-1) and anti-angiogenic factors (vascular endothelial growth inhibitor (VEGI), TSP-1 and -2) were determined by real time RT-PCR. Production of VEGI and TSP-1 was also estimated by ELISA. RESULTS: Immunohistochemistry showed the increase of lymphocyte infiltration, vascular density and VEGF expression in I compared to N/R synovial biopsies. Synovial cells from I areas produced more IL-6, IL-8 and VEGF but less TSP-1 than cells isolated from N/R synovial biopsies. The expression of pro-angiogenic factors by SFC was stimulated by IL-1β. A time dependent regulation of the expression of anti-angiogenic factor genes was observed. IL-1β stimulated the expression of anti-angiogenic factor genes but inhibited it after 24 h. CS reversed the inhibitory effect of IL-1β on anti-angiogenic factors, VEGI and TSP-1. CONCLUSIONS: We demonstrated that synovial biopsies from I areas expressed a pro-angiogenic phenotype. IL-1β induced an imbalance between pro- and anti-angiogenic factors in SFC and CS tended to normalize this IL-1β-induced imbalance, providing a new possible mechanism of action of this drug. [less ▲]

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See detailFibulin-3 fragments (FIB3-1 and FIB3-2) are potential new biomarkers for the diagnosis of osteoarthritis
Gharbi, M; Dubuc, JE; Deberg, M et al

in Annals of the Rheumatic Diseases (2011), 70(Suppl 3), 354

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See detailColl2-1, Coll2-1 NO2 and myeloperoxidase in OA patients before and after hip or knee replacement
Deberg, M; Labasse, A; Quettier, E et al

Conference (2006)

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See detailColl2-1, Coll2-1 NO2 and myeloperoxydase in OA patients before and after hip or knee replacement
Deberg, M; Labasse, A; Quettier, E et al

in Osteoporosis International (2006)

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See detailEvaluation isocinétique des muscles de la hanche chez le patient coxarthrosique
Henrotin, Yves ULg; Ralet, B.; Croisier, Jean-Louis ULg et al

in Actes des 4èmes Journées Belges d’Isocinétisme (2003, October)

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See detailIsokinetic evaluation of knee extensors and flexors in patients with unilateral symptomatic gonarthrotis
Henrotin, Yves ULg; Croisier, Jean-Louis ULg; Dubuc, JE et al

in Clinical Rheumatology (2001), 20

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See detailIsokinetic evaluation of knee extensors and flexors in patients with unilateral symptomatic gonarthrosis
Henrotin, Yves ULg; Croisier, Jean-Louis ULg; Dumont, R. et al

in Isokinetics & Exercise Science (2000, March), 8

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See detailIsokinetic evaluation of knee extensors and flexors in patients with unilateral symptomatic gonarthrosis
Henrotin, Yves ULg; Croisier, Jean-Louis ULg; Dumont, R et al

in Annals of the Rheumatic Diseases (2000), 59(S1), 275

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See detailIntérêt de l'évaluation isocinétique du genou gonarthrosique
Henrotin, Yves ULg; Croisier, Jean-Louis ULg; Dumont, R. et al

in Actes de la 2e Journée Belge d'Isocinétisme (1999, March 20)

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See detailIsokinetic evaluation of knee extensors and flexors in patients with unilateral symptomatic gonarthrosis
Henrotin, Yves ULg; Croisier, Jean-Louis ULg; Dumont, R et al

in Osteoarthritis and Cartilage (1999), 7(SA), 94

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See detailGonarthrose: intérêt de l'évaluation isocinétique
Croisier, Jean-Louis ULg; Henrotin, Yves ULg; Dumont, R. et al

in KINE 2000 (1998, December), 9(98/5), 90

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See detailIsokinetic testing of knee musculature in patient with unilateral gonarthrosis
Henrotin, Yves ULg; Croisier, Jean-Louis ULg; Dumont, R. et al

in Revue du Rhumatisme (English ed.) (1997, November), 11

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See detailEvaluation isocinétique concentrique du genou chez le patient gonarthrosique
Henrotin, Yves ULg; Croisier, Jean-Louis ULg; Dumont, R. et al

in Revue du Rhumatisme et des Maladies Osteo-Articulaires (1997, November), 11

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