The impact of concomitant rhinitis on asthma-related quality of life and asthma control.
; ; et al
in Allergy (2010)
To cite this article: Vandenplas O, Dramaix M, Joos G, Louis R, Michils A, Verleden G, Vincken W, Vints A-M, Herbots E, Bachert C. The impact of concomitant rhinitis on asthma-related quality of life and ... [more ▼]
To cite this article: Vandenplas O, Dramaix M, Joos G, Louis R, Michils A, Verleden G, Vincken W, Vints A-M, Herbots E, Bachert C. The impact of concomitant rhinitis on asthma-related quality of life and asthma control. Allergy 2010; DOI: 10.1111/j.1398-9995.2010.02365.x. Abstract Background: Characterizing the interactions between the upper and lower airways is important for the management of asthma. This study aimed at assessing the specific impact of concomitant rhinitis on asthma-related quality of life (QOL) and asthma control. Methods: A cross-sectional, observational survey was conducted among 1173 patients with asthma (aged 12-45) recruited by general practitioners and chest physicians. AR was defined by self-reported rhinitis symptoms and previously documented sensitization to inhalant allergens. The primary outcomes were (1) asthma control assessed by the Asthma Control Questionnaire (ACQ) and (2) asthma-specific QOL evaluated through the Mini Asthma Quality of Life Questionnaire (mAQLQ). Results: AR was present in 73.9% of the population with asthma and nonallergic rhinitis (NAR) in 13.6%. AR and NAR were associated with an increased risk of uncontrolled asthma (i.e. ACQ score > 1.5) with adjusted odds ratios (OR) of 2.00 (95% confidence interval [CI]: 1.35-2.97) and 1.77 (95%CI: 1.09-2.89), respectively. Multivariate linear regression analysis showed that AR and NAR had a modest, although significant, negative impact on the global mAQLQ score (beta coefficient: -0.293, standard error [SE]: 0.063 and beta coefficient: -0.221, SE: 0.080, P < 0.001, respectively), even after adjustment for the level of asthma control and demographic characteristics. Conclusion: This survey provides direct evidence that AR and NAR are associated with an incremental adverse impact on the disease-specific QOL of patients with asthma and the level of asthma control. Further investigations are required to determine whether appropriate treatment of rhinitis would efficiently reduce asthma morbidity. [less ▲]Detailed reference viewed: 29 (4 ULg)
Alcohol consumption and the prevalence of metabolic syndrome : a meta-analysis of observational studies
; ; et al
Poster (2009)Detailed reference viewed: 13 (1 ULg)
Deux protocoles d’hyperimmunisation au moyen de vaccins marqués réduisent l’incidence de séroconversion envers l’herpèsvirus bovin 1 en cheptels laitiers : résultats d’une étude sur le terrain
; ; et al
in Annales de Médecine Vétérinaire (2004), 148(1), 47-61
A 28 months long cohort study was organized in dairy herds in Belgium, to assess the efficacy of hyperimmunisation as a tool for the control of infectious bovine rhinotracheitis. Two protocols of ... [more ▼]
A 28 months long cohort study was organized in dairy herds in Belgium, to assess the efficacy of hyperimmunisation as a tool for the control of infectious bovine rhinotracheitis. Two protocols of hyperimmunisation in which glycoprotein-E deleted marker vaccines were repeatedly administered were compared to a positive control group in which the usual vaccination protocols were authorised. The two hyperimmunisation protocols differed in the primovaccination : the first group was treated with an attenuated vaccine firstly given intra-nasally then by intramuscular route whereas the second group was given an inactivated vaccine by subcutaneous injection. Afterwards, booster vaccinations were the same in both groups : an inactivated vaccine was administered by subcutaneous route every 6 months. In the control group, as a rule, part of the herd was vaccinated annually. For each group, 6 half-yearly reports specify : 1. the evolution of the population, categorized by birth half-year, 2. the incidence of seroconversion against gE in the cohorts and 3. the evolution of the gE seroprevalence. The survival curves of the hyperimmunised groups show a significantly higher proportion (P < 0,001) of animals remaining seronegative against glycoprotein- E compared to the positive control group. No significant difference was shown between the two protocols of hyperimmunisation. Both of them could then be used as tools for the control of infectious bovine rhinotracheitis. [less ▲]Detailed reference viewed: 55 (0 ULg)
Ineffectiveness of chloroquine antenatal prophylaxis in East of Democratic Republic of Congo (RDC).
; ; Porignon, Denis et al
in Tropical doctor (2003), 33(3), 177-178Detailed reference viewed: 17 (7 ULg)
Références et issues des accouchements au Kivu, République démocratiquedu Congo
; ; Porignon, Denis et al
in Revue d'Epidémiologie et de Santé Publique = Epidemiology and Public Health (2003), 51(2), 237-244
BACKGROUND: The process of referral between the first and the second level of the health system in the Democratic Republic of Congo is poorly understood. This report intends to study the association ... [more ▼]
BACKGROUND: The process of referral between the first and the second level of the health system in the Democratic Republic of Congo is poorly understood. This report intends to study the association between the referral and the hospital perinatal outcomes. METHODS: Delivery outcomes in a retrospective cohort of 1162 women admitted between June 95 and May 96, in two referral hospitals in Kivu were analyzed according to the referral status and the women's characteristics. RESULTS: Forty-three percent (n=492)of women admitted, corresponding to 2.3% of expected pregnant women, were referred. Referred women had higher risks of obstetrical complications (OR=2.0; CI95%: 1.3-3.1) and intervention (OR=1.5; CI95%: 1.0-2.3) and similar risks of low birth weight and perinatal mortality. Women with complications during the antenatal period had a double risk of intervention and perinatal mortality. The risk of obstetrical intervention was lower when women had attended 2 visits (OR=0.5; CI95%: 0.3-0.8); the risk of low birth weight was lowest only for mothers who had attended one visit (OR=0.5; CI95%: 0.3-0.9). Distance > or =90 minutes walking from home to hospital raised the risk of obstetrical complication (OR=1.7; CI95%: 1.1-2.5), the risk of obstetrical intervention (OR=1.5; CI95%: 1.0-2.1), and the risk of perinatal mortality (OR=1.6; CI95%: 1.0-2.7). Late admission raised the risk of perinatal mortality (OR=1.8; CI95%: 1.2-2.9) and lowered the risk of obstetrical complication (OR=0.7; CI95%: 0.5-1.0). Part payment of care was associated with higher risks of low birth weight (OR=1.9; CI95%: 1.3-2.9), perinatal mortality (OR=2.2; CI95%: 1.4-3.5) and obstetrical intervention (OR=2.4; CI95%: 1.7-3.4). CONCLUSION: These results suggest a deficit of referred cases considering that 15% of pregnant women in the area covered by the referral hospitals should have been referred. They confirm the negative influence of economic and geographic constraints on the delivery outcomes. They point out the relevance of making reorganization of the referral system a priority. [less ▲]Detailed reference viewed: 4 (0 ULg)
The unseen face of humanitarian crisis in eastern Democratic Republic of Congo: was nutritional relief properly targeted?
Porignon, Denis ; ; et al
in Journal of epidemiology and community health (2000), 54(1), 6-9
STUDY OBJECTIVE: Comparison of children's nutritional status in refugee populations with that of local host populations, one year after outbreak refugee crisis in the North Kivu region of Democratic ... [more ▼]
STUDY OBJECTIVE: Comparison of children's nutritional status in refugee populations with that of local host populations, one year after outbreak refugee crisis in the North Kivu region of Democratic Republic of Congo. DESIGN: Cross sectional surveys. SETTING: Temporary and other settlements, in the town of Goma and surrounding rural areas. SUBJECTS: Anthropometric indicators of nutritional status and presence or absence of oedema were measured among 5121 children aged 6 to 59 months recruited by cluster sampling with probability proportional to size, between June and August 1995. RESULTS: Children in all locations demonstrated a typical pattern of growth deficit relative to international reference. Prevalence of acute malnutrition (wt/ht < -2 Z score) was higher among children in the rural non-refugee populations (3.8 and 5.8%) than among those in the urban non-refugee populations (1.4%) or in the refugee population living in temporary settlements (1.7%). Presence of oedema was scarcely noticed in camps (0.4%) while it was a common observation at least in the most remote rural areas (10.1%). As compared with baseline data collected in 1989, there is evidence that nutritional status was worsening in rural non-refugee populations. CONCLUSIONS: Children living in the main town or in the refugee camps benefited the most from nutritional relief while those in the rural non-refugee areas were ignored. This is a worrying case of inequity in nutritional relief. [less ▲]Detailed reference viewed: 5 (0 ULg)
Prognostic indices for mortality of hospitalized children in central Africa.
; ; et al
in American journal of epidemiology (1996), 143(12), 1235-43
A hospital-based follow-up study was conducted between 1986 and 1988 at Lwiro (South Kivu Province, Zaire). Of 1,129 children in the study, three of four were severely malnourished, and 17.4% died. This ... [more ▼]
A hospital-based follow-up study was conducted between 1986 and 1988 at Lwiro (South Kivu Province, Zaire). Of 1,129 children in the study, three of four were severely malnourished, and 17.4% died. This study analyzes the mortality in hospital; its objectives are to evaluate the prognostic power of edema and anthropometric and biologic indicators and to seek indices that perform better. Receiver operating characteristic curves were established for each parameter under study and for each index constructed. Areas under receiver operating characteristic curves were highest for biologic indicators, and simple indices, obtained by counting the number of risk factors present, performed best. In the absence of biologic parameters, the authors suggest classifying children as at risk of dying when they present with edema and/or with arm circumference of less than 115 mm. When biologic measurements are possible, in addition to edema and arm circumference, the authors suggest taking serum albumin and transthyretin into account. For serum albumin and transthyretin, mortality risk is defined in terms of values of less than 16 g/liter and 6.5 mg/dl, respectively. Children will be classified as at risk of dying when they present with at least two of the four risk factors. The resulting diagnostic test has a high sensitivity (91.2%) and positive and negative predictive values of 40.8% and 97.9%, respectively. [less ▲]Detailed reference viewed: 3 (0 ULg)