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See detailMeasurement of urinary biomarkers of parabens, benzophenone-3 and phthalates in a Belgian population
Dewalque, Lucas ULg; PIRARD, Catherine ULg; Charlier, Corinne ULg

in BioMed Research International (2014), 2014(Article ID 649314,), 1-13

Parabens, benzophenone-3 (BP3) and phthalates are commonly used as antimicrobial conservator, UV-filter and plasticizer respectively, and are thought to exhibit endocrine disrupting properties. These ... [more ▼]

Parabens, benzophenone-3 (BP3) and phthalates are commonly used as antimicrobial conservator, UV-filter and plasticizer respectively, and are thought to exhibit endocrine disrupting properties. These endocrine disrupting activities have been recently assumed to lead to cutaneous malignant melanoma. Humans are exposed to these chemicals through different sources such as food, personal care products or cosmetics. In this study we measured urinary levels of 4 parabens, BP3 and 7 metabolites of phthalates in samples collected from 261 participants living in and around Liege (Belgium). The analyses were carried out by liquid chromatography tandem mass spectrometry (LC-MS/MS) using isotopic dilution. To the best of our knowledge, this is the first time that the urinary levels of these 3 classes of chemicals are reported for the same general population in Belgium. Most of the parabens, the BP3 and all the phthalate metabolites were detected in 82.8 to 100.0% of the samples. For most of these chemicals, the exposure patterns significantly differ between children and adults, but also between males and females, especially with higher concentrations of parabens and phthalate metabolites in female and children subjects respectively. [less ▲]

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See detailSimultaneous determination of some phthalate metabolites, parabens and benzophenone-3 in urine by ultra high pressure liquid chromatography tandem mass spectrometry
Dewalque, Lucas ULg; PIRARD, Catherine ULg; DUBOIS, Nathalie ULg et al

in Journal of Chromatography. B : Analytical Technologies in the Biomedical & Life Sciences (2014), 949-950

Phthalates, parabens and 2-hydroxy-4-methoxybenzophenone or benzophone-3 are thought to act as endocrine disrupting chemicals, being able to disrupt the endocrine balance and therefore able to lead to ... [more ▼]

Phthalates, parabens and 2-hydroxy-4-methoxybenzophenone or benzophone-3 are thought to act as endocrine disrupting chemicals, being able to disrupt the endocrine balance and therefore able to lead to some hormonal diseases. Numerous large-scale biomonitoring studies have detected the biomarkers of these compounds in more than 75% of the general population. To assess the exposure to these chemicals, we developed an analytical method based on a Solid Phase Extraction (SPE) prior to ultra high pressure liquid chromatographytandem mass spectrometry (UPLC-MS/MS) for the simultaneous measurement of seven phthalate metabolites (monobenzyl phthalate, mono-n-butyl phthalate, mono-iso-butyl phthalate, mono-2-ethylhexyl phthalate, mono-2-ethyl-5-hydroxyhexyl phthalate, mono-2- ethyl-5-oxohexyl phthalate, monoethyl phthalate), four parabens (methyl paraben, ethyl paraben, n-propyl paraben, n-butyl parabens) and benzophenone-3 in human urine. The distinction between unconjugated, glucuro- and sulfoconjugated forms was achieved using different enzymatic hydrolyses. The whole procedure was validated according to the total error approach, and was demonstrated to be linear (regression coefficient ranging from 0.987 to 0.998) and accurate (inter and intra assay precision <17.71%, relative bias <5.87%) in the dosing range of concentrations. The limits of quantification (LOQs) obtained ranged between 0.30 and 1.23 ng/ml depending on the analyte. The reliability of the method was proven in passing successfully the German External Quality Assessment Scheme (G-EQUAS). Moreover, the urine from 25 volunteers were analyzed for the determination of glucuro-, sulfo- and free species separately. Phthalate metabolites, parabens and benzophenone-3 were positively detected in almost all urine samples, with detection rates ranging from 40 to 100%. Levels measured ranged from <LOQ to 2207 ng/ml varying widely depending on the compound and the individual. In our small participating population, most of the phthalate metabolites were excreted predominately as glucuroconjugated forms while parabens and benzophenone-3 were detected as glucuro- and sulfoconjugated species in variable proportions according to the target compound. [less ▲]

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See detailDétection des signaux faibles des perturbateurs endocriniens en santé environnementale
Dewalque, Lucas ULg; Charlier, Corinne ULg

in Environnement Risques & Santé (2013), 12(4), 345-351

Dans l’étude de l’impact des produits chimiques à effet perturbateur endocrinien sur la santé de l’homme, l’apport du laboratoire de toxicologie est significatif. En effet, il peut aider à établir le ... [more ▼]

Dans l’étude de l’impact des produits chimiques à effet perturbateur endocrinien sur la santé de l’homme, l’apport du laboratoire de toxicologie est significatif. En effet, il peut aider à établir le risque toxique pour l’homme des polluants de l’environnement par des mesures d’exposition (identification et dosage des principaux polluants) ou des mesures d’effet, dans les différents compartiments de l’environnement, sur des populations sentinelles, ou sur l’homme. [less ▲]

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See detailQuantitative determination of non persistent endocrine disruptors in human urine
Dewalque, Lucas ULg; PIRARD, Catherine ULg; DUBOIS, Nathalie ULg et al

in Acta Clinica Belgica (2013), 68(6),

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See detailLa fertilité masculine menacée par la présence de perturbateurs endocriniens dans l'environnement ?
Dewalque, Lucas ULg; Charlier, Corinne ULg

in Revue Médicale de Liège (2012), 67(5-6), 243-249

Les perturbateurs endocriniens sont des substances chimiques interférant avec le système hormonal. Ces polluants, présents dans l’environnement, peuvent entraîner l’apparition de maladies chez l’Homme ... [more ▼]

Les perturbateurs endocriniens sont des substances chimiques interférant avec le système hormonal. Ces polluants, présents dans l’environnement, peuvent entraîner l’apparition de maladies chez l’Homme. Dans cet article, nous nous intéressons à ces produits chimiques à effets perturbateurs endocriniens susceptibles d’entraîner une diminution de la qualité du sperme et un syndrome de dysgénésie testiculaire, deux pathologies impliquées dans le déclin de la fertilité masculine. La question de l’influence environnementale sur cette pathologie complexe qu’est l’hypofertilité masculine prend ici tout son sens. [less ▲]

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