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See detailNeurofibromatose de type 1
Hermanns-Le, Trinh ULg; Devillers, Céline ULg; Franchimont, Claudine ULg et al

in Revue Médicale de Liège (2009), 64

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See detailPseudolymphomes cutanés et pseudoclonalité des infiltrats lymphoïdes.
Quatresooz, Pascale ULg; Franchimont, Claudine ULg; Devillers, Céline ULg et al

in Revue Médicale de Liège (2009), 64

Cutaneous pseudolymphomas represent an heterogeneous group of tumours resembling lymphomas by some clinical and histological aspects. They are distinguished, in particular, by their benign evolution. The ... [more ▼]

Cutaneous pseudolymphomas represent an heterogeneous group of tumours resembling lymphomas by some clinical and histological aspects. They are distinguished, in particular, by their benign evolution. The histological and immunohistological examinations combined with molecular biology help to elucidate any diagnostic uncertainty. In these diseases, monoclonality and pseudoclonality must be distinguished in the lymphoid infiltrates. Searching for any specific etiology is important because removing the cause is likely to clear the lesions. [less ▲]

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See detailComment j'explore... des lésions cutanées chez un toxicomane adepte de la cocaïne ou du crack.
Devillers, Céline ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg et al

in Revue Médicale de Liège (2009), 64

Both cocaine and crack exert sympathetic and prothrombotic effects. The induced lesion may affect the skin, and other organ systems as well. Various types of vasculitis and infectious dermatoses are the ... [more ▼]

Both cocaine and crack exert sympathetic and prothrombotic effects. The induced lesion may affect the skin, and other organ systems as well. Various types of vasculitis and infectious dermatoses are the predominant issues. In addition, tactile and visual hallucinations may occur suggesting insect crawling underneath the skin. [less ▲]

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See detailNodules violacés sporotrichoïdes chez une patiente immunodéprimée.
Devillers, Céline ULg; Franchimont, Claudine ULg; Quatresooz, Pascale ULg et al

in Dermatologie Actualité (2009), 115

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See detailL'image du mois. Chancre mixte, combinaison d'un chancre mou et d'un chancre syphilitique.
Henry, Frédérique ULg; Devillers, Céline ULg; Szepetiuk, Grégory ULg et al

in Revue Médicale de Liège (2009), 64(4), 177-8

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See detailFungal chitin-glucan scaffold for managing diabetic xerosis of the feet in menopausal women.
Quatresooz, Pascale ULg; Franchimont, Claudine ULg; Szepetiuk, Grégory ULg et al

in Expert Opinion on Pharmacotherapy (2009), 10(14), 2221-9

BACKGROUND: Corneocyte accumulation (hyperkeratosis, xerosis) commonly occurs in the stratum corneum (SC) of the feet of diabetic patients, as well as menopausal women. OBJECTIVE: To compare the effects ... [more ▼]

BACKGROUND: Corneocyte accumulation (hyperkeratosis, xerosis) commonly occurs in the stratum corneum (SC) of the feet of diabetic patients, as well as menopausal women. OBJECTIVE: To compare the effects of a 2.5% chitin-glucan formulation with its placebo, and commercially available glycerol formulations. METHODS: This two-step controlled double-blind, randomized, intra-individual study was performed in 30 type 1 and 2 diabetic menopausal women suffering from xerosis of the feet. The formulations were applied once daily for 3 weeks. Electrometric assessments were performed on three sites of the feet at entry in the study, at weekly intervals during the treatment phase, and in a 2-week follow-up out of treatment. Positive controls consisted in two commercially available formulations enriched in glycerol. RESULTS: Data revealed an unequivocal benefit provided by the 2.5% chitin-glucan formulation compared with placebo. The electrometric values were significantly higher at each evaluation time during both treatment and follow-up phases. The two glycerol-enriched formulations showed slightly different kinetics of SC moisturization. A steep increase was followed by a plateau level and a rapid decline after stopping the treatments. CONCLUSION: The increased moisturization of the SC of the sole probably improves the desquamation process and reduces xerosis of the soles. [less ▲]

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See detailComment j'explore...une escarre de decubitus.
Devillers, Céline ULg; Franchimont, Claudine ULg; Giet-Lesuisse, M. et al

in Revue Médicale de Liège (2009), 64(10), 535-7

Pressure ulcers represent a major health problem causing both considerable morbidity and a high financial burden for the healthcare system. The geriatric segment of the population at risk of pressure ... [more ▼]

Pressure ulcers represent a major health problem causing both considerable morbidity and a high financial burden for the healthcare system. The geriatric segment of the population at risk of pressure ulcer is progressively increasing. This condition occurs at home, in old people's homes and in hospitals as well. The severity, duration and orientation of forces applied to the skin represent the most important factors responsible for pressure ulcers. Prevention measures are essential to reduce the prevalence of the disease. [less ▲]

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See detailLe carcinome de Merkel: du diagnostic a la prise en charge therapeutique.
Franchimont, Claudine ULg; Devillers, Céline ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2009), 64(10), 500-5

Merkel cell carcinoma is a skin malignancy showing an increasing trend of incidence in the white population. Its viral origin due to the MC polyomavirus is likely. The diagnosis relies on the histological ... [more ▼]

Merkel cell carcinoma is a skin malignancy showing an increasing trend of incidence in the white population. Its viral origin due to the MC polyomavirus is likely. The diagnosis relies on the histological and targeted immunopathological examinations. Histoprognostic criteria remain to be defined. An assessment using medical imaging is important to establish. Treatments rely on surgery and radiotherapy. Chemotherapy is mandatory at the metastatic stage. Some biotherapies are potentially active. [less ▲]

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See detailGranulome de Majocchi sur tinea incognito chez une Africaine.
Devillers, Céline ULg; Willemaers, V.; Lesuisse, Marianne et al

in Dermatologie Actualité (2009), 116

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See detailStreamlining of cellulite concepts.
Pierard, Gérald ULg; Devillers, Céline ULg; Franchimont, Claudine ULg

in European Dermatology (2009), 4

Basically, cellulite is a gender-related condition. It is not a result of increased body mass, but its aspect may be influenced by the waist-to-hip ratio. There are glaring discrepancies in the ... [more ▼]

Basically, cellulite is a gender-related condition. It is not a result of increased body mass, but its aspect may be influenced by the waist-to-hip ratio. There are glaring discrepancies in the microanatomical descriptions regarding this condition. A lumpy aspect of the dermo-hypodermal interface is often mentioned, but this aspect rather represents a gender-linked characteristic of the thighs and buttocks of women without being a specific sign of cellulite. Incipient cellulite recognized by a discrete padded look or “orange peel” aspect appears correlated with the presence of a network of focally enlarged fibrosclerotic strands partitioning the hypodermis and serving as a physiologic buttress limiting the outpouching of fat lobules on pinching the skin. Such connective tissue structures have been ascribed to be the result of a hormonal-dependent reactive process to sustained mechanical tensions caused by the adipocyte lobules. Full blown cellulite is recognized by a lumpy-bumpy and dimpled skin surface. It likely represents subjugation of the hypertrophic response of the hypodermal connective tissue strands when their resistance is overcome by progressive fat accumulation. In these cases, histological aspects reminiscent of striae distensae are identified within the hypodermal connective tissue strands. The mechanical properties of skin involved in the cellulite process are altered. They influence the mechanobiology of connective tissue cells, in particular the Factor XIIIa-positive dermal dendrocytes. [less ▲]

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See detailComment je traite... une hidradénite suppurée
Devillers, Céline ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2009), 64

Hidradenitis suppurativa is a chronic and debilitating inflammatory disease. It presents as recurrent abcesses, sinus tracts and scarring. The condition usually develops in the axillae and groins, and ... [more ▼]

Hidradenitis suppurativa is a chronic and debilitating inflammatory disease. It presents as recurrent abcesses, sinus tracts and scarring. The condition usually develops in the axillae and groins, and more rarely involves the breasts, perineum and buttocks. There are many myths around hidradenitis suppurativa including its origin and pathomechanisms. Some antibiotics as well as corticosteroids and other immune downregulators are porly effective in this stubborn condition. By contrast, TNF-α antagonists appear promising. Radical surgery is another effective option. [less ▲]

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See detailComment j'explore ... une rarefaction des sourcils.
Devillers, Céline ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2009), 64(1), 49-51

The rarefaction or loss of eyebrow hair may represent an esthetic complaint or a peculiar finding associated with a given disease. The causal disorders correspond to a few dermatitides and several ... [more ▼]

The rarefaction or loss of eyebrow hair may represent an esthetic complaint or a peculiar finding associated with a given disease. The causal disorders correspond to a few dermatitides and several endocrine, auto-immune, infectious, neoplastic, traumatic, iatrogenic and genetic disorders. [less ▲]

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See detailPET for carcinomas of the genitourinary system
Belhocine, Tarik; Hustinx, Roland ULg; Devillers, Céline ULg et al

in Khakhali, I.; Laublant, J.; Goldsmith, S. J. (Eds.) NUCLEAR ONCOLOGY : DIAGNOSIS AND THERAPY (2000)

This book is intended to provide the state-of-the-art in the present knowledge of the fast growing field of nuclear oncology. The enormous sum of data it gathers is presented by the leading authors in ... [more ▼]

This book is intended to provide the state-of-the-art in the present knowledge of the fast growing field of nuclear oncology. The enormous sum of data it gathers is presented by the leading authors in their respective fields. Recent breakthrough as well as validated techniques are explained in details. Among the most stimulating issues, it becomes clear that the long awaited era of radioimmunotherapy is finally coming to reality and is close to enter into routine clinical use. Several chapters are devoted to this future important aspect of our practice. They should allow the reader to become quickly and completely informed about the main results of the recent trials and also to comprehend the expected evolutions in this field. Positron emission tomography (PET) also occupies a large place. Numerous illustrations help the reader to appreciate the wide capabilities of this technique. The more usual radiopharmaceuticals labeled by single photons emitters are not forgotten and all the aspects of the daily practice of nuclear oncology are covered, from thyroid and bone imaging to sentinel lymph node detection. The first part of the book covers transversally the field of nuclear oncology. A radiopharmaceuticals chapter provides an in-depth review of the properties and chemistry of the single-photon and positron emitters radionuclides. The various mechanisms of localization are also described at the membrane level as well as for metabolic substrates. The properties of the agents aiming at hormone receptors and tumor antigens are excellently described, as well as the recently introduced gene expression imaging. Multidrug resistance (MDR) is divided in two parts. The breast cancer chapter retraces the history and background of sestamibi in the detection of MDR. It also describes the methodology and clinical results of the most important scintigraphic studies that have demonstrated the possibility to detect the early development of resistance to chemotherapy. An interesting series of other agents with a high potential in this indication, particularly positron emitters, is discussed. The role of technetium and positron agents for MDR detection in other tumor localisations, especially in the lung, is also well covered. An instrumentation chapter goes through the fundamentals of planar and SPECT imaging, and also presents the new reconstruction and correction algorithms. A large section is occupied by positron imaging. The pros and cons of dedicated detector and camera coincidence are very well detailed. This part should definitely help to decide those who are trying to make a choice between these two options. The general principles of radiolabeled monoclonal antibodies imaging and therapy are covered in two very interesting chapters. Then radiotherapy of painful bone metastases compares the capabilities of the various agents available. A large chapter deals with pediatric nuclear oncology, in particular neuroblastoma, bone and central nervous system tumors. Finally, the often forgotten role of nuclear medicine in the detection, and possibly in the prevention, of the cardiotoxicity and nephrotoxicity resulting from cancer therapy are addressed at the end of that first part. The second part of the book goes by organ and begins by addressing brain tumors. A vast chapter is devoted to PET imaging. Besides the tracers and instrumentation issues, patient management occupies a central place, in particular with discussion on the role of nuclear medicine in tissue characterization, treatment planning and assessment of treatment response. Cerebrospinal fluid and shunt imaging are described, with particular attention paid to ventriculoperitoneal shunts. After PET imaging of head and neck carcinoma, a chapter extensively reviews thyroid carcinoma. Iodine therapy and long-term monitoring are covered with great details and useful practical recommendations are provided. Emerging radioimmunotherapy is discussed apart. Parathyroid scintigraphy also occupies a large and well documented chapter. PET imaging of lung carcinoma is particularly well illustrated by several cases. The potential of peptide scintigraphy is presented. Breast cancer occupies five chapters, namely, scintimammography, PET imaging, lymphatic mapping, monoclonal antibody imaging and radionuclide therapy. This provides an extensive review of the present and potential possibilities of nuclear medicine in one of the most frequent tumors. Then the role of PET imaging and the capabilities of radioimmunotherapy for maligancies of the gastrointestinal and genitourinary tracts are presented, in particular in two chapters entirely dedicated to prostate carcinoma and in two others to ovarian carcinoma. Radiolabeled somatostatin analogues and their value in the diagnosis and treatment of the neuroendocrine tumors are reviewed. Hepatic neoplasia are addressed through the utilization of technetium-labeled galactosyl neoglycoalbumin and hepatic artery infusion. For lymphomas, besides gallium and PET imaging, a very complete chapter is devoted to monoclonal antibody therapy. The extremely promising results obtained with several radiolabeled-anti-CD monoclonal antibodies in the treatment of B-cell non-Hodgkin’s lymphomas are reviewed in depth. Additional chapters cover adrenal tumors, melanoma, musculoskeletal tumors, in particular imaging of bone metastases. This comprehensive, didactic, up-to-date, well illustrated review of nuclear oncology should help nuclear medicine physicians as well as oncologists to optimize their practice. This book is intended to provide the state-of-the-art in the present knowledge of the fast growing field of nuclear oncology. The enormous sum of data it gathers is presented by the leading authors in their respective fields. Recent breakthrough as well as validated techniques are explained in details. Among the most stimulating issues, it becomes clear that the long awaited era of radioimmunotherapy is finally coming to reality and is close to enter into routine clinical use. Several chapters are devoted to this future important aspect of our practice. They should allow the reader to become quickly and completely informed about the main results of the recent trials and also to comprehend the expected evolutions in this field. Positron emission tomography (PET) also occupies a large place. Numerous illustrations help the reader to appreciate the wide capabilities of this technique. The more usual radiopharmaceuticals labeled by single photons emitters are not forgotten and all the aspects of the daily practice of nuclear oncology are covered, from thyroid and bone imaging to sentinel lymph node detection. The first part of the book covers transversally the field of nuclear oncology. A radiopharmaceuticals chapter provides an in-depth review of the properties and chemistry of the single-photon and positron emitters radionuclides. The various mechanisms of localization are also described at the membrane level as well as for metabolic substrates. The properties of the agents aiming at hormone receptors and tumor antigens are excellently described, as well as the recently introduced gene expression imaging. Multidrug resistance (MDR) is divided in two parts. The breast cancer chapter retraces the history and background of sestamibi in the detection of MDR. It also describes the methodology and clinical results of the most important scintigraphic studies that have demonstrated the possibility to detect the early development of resistance to chemotherapy. An interesting series of other agents with a high potential in this indication, particularly positron emitters, is discussed. The role of technetium and positron agents for MDR detection in other tumor localisations, especially in the lung, is also well covered. An instrumentation chapter goes through the fundamentals of planar and SPECT imaging, and also presents the new reconstruction and correction algorithms. A large section is occupied by positron imaging. The pros and cons of dedicated detector and camera coincidence are very well detailed. This part should definitely help to decide those who are trying to make a choice between these two options. The general principles of radiolabeled monoclonal antibodies imaging and therapy are covered in two very interesting chapters. Then radiotherapy of painful bone metastases compares the capabilities of the various agents available. A large chapter deals with pediatric nuclear oncology, in particular neuroblastoma, bone and central nervous system tumors. Finally, the often forgotten role of nuclear medicine in the detection, and possibly in the prevention, of the cardiotoxicity and nephrotoxicity resulting from cancer therapy are addressed at the end of that first part. The second part of the book goes by organ and begins by addressing brain tumors. A vast chapter is devoted to PET imaging. Besides the tracers and instrumentation issues, patient management occupies a central place, in particular with discussion on the role of nuclear medicine in tissue characterization, treatment planning and assessment of treatment response. Cerebrospinal fluid and shunt imaging are described, with particular attention paid to ventriculoperitoneal shunts. After PET imaging of head and neck carcinoma, a chapter extensively reviews thyroid carcinoma. Iodine therapy and long-term monitoring are covered with great details and useful practical recommendations are provided. Emerging radioimmunotherapy is discussed apart. Parathyroid scintigraphy also occupies a large and well documented chapter. PET imaging of lung carcinoma is particularly well illustrated by several cases. The potential of peptide scintigraphy is presented. Breast cancer occupies five chapters, namely, scintimammography, PET imaging, lymphatic mapping, monoclonal antibody imaging and radionuclide therapy. This provides an extensive review of the present and potential possibilities of nuclear medicine in one of the most frequent tumors. Then the role of PET imaging and the capabilities of radioimmunotherapy for maligancies of the gastrointestinal and genitourinary tracts are presented, in particular in two chapters entirely dedicated to prostate carcinoma and in two others to ovarian carcinoma. Radiolabeled somatostatin analogues and their value in the diagnosis and treatment of the neuroendocrine tumors are reviewed. Hepatic neoplasia are addressed through the utilization of technetium-labeled galactosyl neoglycoalbumin and hepatic artery infusion. For lymphomas, besides gallium and PET imaging, a very complete chapter is devoted to monoclonal antibody therapy. The extremely promising results obtained with several radiolabeled-anti-CD monoclonal antibodies in the treatment of B-cell non-Hodgkin’s lymphomas are reviewed in depth. Additional chapters cover adrenal tumors, melanoma, musculoskeletal tumors, in particular imaging of bone metastases. This comprehensive, didactic, up-to-date, well illustrated review of nuclear oncology should help nuclear medicine physicians as well as oncologists to optimize their practice. [less ▲]

Detailed reference viewed: 34 (4 ULg)