References of "Detilleux, Julien"
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See detailHigher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis.
El Hour, Mehdi ULg; Moncada-Pazos, A.; Blacher, Silvia ULg et al

in Oncogene (2010), 29(20), 3025-32

ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) constitute a family of endopeptidases related to matrix metalloproteinases. These proteases have been largely implicated in ... [more ▼]

ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) constitute a family of endopeptidases related to matrix metalloproteinases. These proteases have been largely implicated in tissue remodeling and angiogenesis associated with physiological and pathological processes. To elucidate the in vivo functions of ADAMTS-12, we have generated a knockout mouse strain (Adamts12−/−) in which Adamts12 gene was deleted. The mutant mice had normal gestations and no apparent defects in growth, life span and fertility. By applying three different in vivo models of angiogenesis (malignant keratinocyte transplantation, Matrigel plug and aortic ring assays) to Adamts12−/− mice, we provide evidence for a protective effect of this host enzyme toward angiogenesis and cancer progression. In the absence of Adamts-12, both the angiogenic response and tumor invasion into host tissue were increased. Complementing results were obtained by using medium conditioned by cells overexpressing human ADAMTS-12, which inhibited vessel outgrowth in the aortic ring assay. This angioinhibitory effect of ADAMTS-12 was independent of its enzymatic activity as a mutated inactive form of the enzyme was similarly efficient in inhibiting endothelial cell sprouting in the aortic ring assay than the wild-type form. Altogether, our results show that ADAMTS-12 displays antiangiogenic properties and protect the host toward tumor progression. [less ▲]

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See detailEffects of Non Genetic and Crossbreeding Factors on Daily Milk Yield of Jersey x Sahiwal x Ankole Cows in Burundi
Hatungumukama, G.; Hornick, Jean-Luc ULg; Detilleux, Julien ULg

in Journal of Animal and Veterinary Advances (2009), 8(4), 794-798

The study was conducted at the Rukoko station located at 21 km North-Western of Bujumbura in the Imbo natural region, in the South of Rusizi River. The objective was to assess the effects of year of ... [more ▼]

The study was conducted at the Rukoko station located at 21 km North-Western of Bujumbura in the Imbo natural region, in the South of Rusizi River. The objective was to assess the effects of year of lactation, genetic group, lactation length, season and parity on the Daily Milk Yield (DMY) of Jersey (J) x Sahiwal (S) x Ankole (A) crossed cows. Milk yields were obtained from cows that have been both Suckled and Milked (SM) or only Milked (M). Data were analyzed using the procedure GLM in SAS on SM and M cows, separately. All factors affected significantly DMY (p<0.001). A significant increase was observed from 1989-1991 due to the improvement of management techniques. During this period, the production raised from 10.07 +/- 0.22 L-11.50 +/- 0.17 L day(-1) for SM cows. Unfortunately, the 1993 civilian war destabilized the managerial techniques and consequently, the milk production decreased. Highest milk yields were observed in crossed cows with 50% of Jersey and 50% of Sahiwal inheritances. Peak yields occurred at the 43rd (12.67 +/- 0.42 L) and 56th (6.42 +/- 0.45 L) days in milk for SM and M cows, respectively. Milk production was significantly higher in January (11.04 +/- 0.23 L day(-1)), in the middle of the rainy season, than in July (7.02 +/- 0.18 L day(-1)), in the middle of the dry season. Milk yield in SM cows increased from 8.15 +/- 0.17 L-9.46 +/- 0.16 L day(-1) during the 1st and the 2nd lactation, respectively. [less ▲]

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