Inhibition of the Blink Reflex R2 Component after Supraorbital and Index Finger Stimulations Is Reduced in Cluster Headache: An Indication for Both Segmental and Suprasegmental Dysfunction?
; Schoenen, Jean ;
in Pain (1997), 71(1), 81-8
Peripheral as well as central mechanisms are thought to play a role in cluster headache pathogenesis. We have studied recovery curves of the R2 component of the blink reflex after conditioning by ... [more ▼]
Peripheral as well as central mechanisms are thought to play a role in cluster headache pathogenesis. We have studied recovery curves of the R2 component of the blink reflex after conditioning by supraorbital or index finger stimuli in 10 episodic cluster headache (CH) patients during a cluster period and in 10 healthy controls. There was no significant change of R2 threshold, latency or area in CH patients. After paired supraorbital stimuli, R2 recovered more rapidly in patients on the symptomatic side. After index stimulations, R2 recovery was more rapid on both symptomatic and non-symptomatic sides in patients compared to controls. Naloxone (0.4 mg) i.v. in two subjects partially reversed the R2 suppression induced by index finger stimuli. The unilateral decrease of R2 inhibition after a segmental supraorbital stimulus most likely reflects sensitisation in the spinal trigeminal nucleus. Whether the latter is due to irritation of the ophthalmic nerve within the cavernous sinus region, which is thought to be pivotal in CH pathogenesis, remains to be proven. In addition, we propose that the bilateral deficit of R2 inhibition after an extrasegmental exteroceptive stimulus might reflect hypoactivity of reticular nuclei, possibly because of reduced central opioid activity. [less ▲]Detailed reference viewed: 10 (0 ULg)
Intraoperative Localisation of the Primary Motor Cortex Using Single Electrical Stimuli
Maertens De Noordhout, Alain ; ; Hans, Pol et al
in Journal of Neurology, Neurosurgery & Psychiatry (1996), 60(4), 442-4
A new method of intraoperative localisation of the primary motor cortex is described, based on the application of single anodal electric pulses to the brain surface. Patients were anaesthetised with ... [more ▼]
A new method of intraoperative localisation of the primary motor cortex is described, based on the application of single anodal electric pulses to the brain surface. Patients were anaesthetised with propofol infusion, and neuromuscular blockade was temporarily alleviated to allow recording of surface EMG responses (CMAPs) to the stimuli. Primary motor areas could be localised in 18/19 patients studied. In the other patient, no responses were elicited, as the operative field was posterior to the motor cortex. When compared with MEPs elicited in awake patients by magnetic stimuli, responses to intraoperative anodal stimulation were of small amplitude (usually less than 10% of MEPs) and their latency was some 1 to 2 ms longer. One month after the operation, only 1/19 patients was left with a slight muscle weakness, although seven showed preoperative motor deficit. The procedure proved easy and fast, needing no preliminary surgery or time consuming preparation. It did not induce any detectable side effects. [less ▲]Detailed reference viewed: 2 (0 ULg)
From Basal Ganglia to Motoneurons. Probable Involvement of Pathways Relaying in the Medulla
; ; Maertens De Noordhout, Alain
in Battistin, L.; Scarlato, G.; Caraceni, T. (Eds.) et al Advances in Neurology. Volume 69 (1996)Detailed reference viewed: 2 (1 ULg)
Potentiation instead of habituation characterizes visual evoked potentials in migraine patients between attacks
Schoenen, Jean ; ; et al
in European Journal of Neurology (1995), 2Detailed reference viewed: 52 (2 ULg)
Effets de la sénescence sur les neurones GABAergiques
; Delwaide, Jean
in Encéphale (L') (1987), 13Detailed reference viewed: 14 (1 ULg)
The effect of TRH on F waves recorded from antagonistic muscles in human subjects.
; Schoenen, Jean
in Annals of Neurology (1985), 18(3), 366-7Detailed reference viewed: 5 (0 ULg)
Mazindol in the treatment of Parkinson's disease.
; Schoenen, Jean ;
in Archives of Neurology (1983), 40(13), 788-90
Mazindol, a drug that blocks the reuptake of dopamine, was studied in the treatment of Parkinson's disease in both a pilot study (12 patients) and a controlled trial (11 patients). The patients had stage ... [more ▼]
Mazindol, a drug that blocks the reuptake of dopamine, was studied in the treatment of Parkinson's disease in both a pilot study (12 patients) and a controlled trial (11 patients). The patients had stage II or III disease, according to the classification of Hoehn and Yahr. Both studies showed that mazindol possessed anti-parkinsonian properties and that the improvement was statistically significant. The therapeutic effect was moderate, but could be of value for patients in the early stages of the disease. The drug was well tolerated; only two patients had side effects. [less ▲]Detailed reference viewed: 13 (1 ULg)
Successful treatment of hemiballismus with progabide, a new GABA-mimetic agent.
Gonce, Michel ; Schoenen, Jean ; et al
in Journal of Neurology (1983), 229(2), 121-4Detailed reference viewed: 46 (0 ULg)
Motoneuropathie hereditaire: la forme proximale de l'adulte liee au sexe (ou maladie de Kennedy). Observations cliniques et neuroendocrinologiques.
Schoenen, Jean ; ; Legros, Jean-Jacques et al
in Journal of the Neurological Sciences (1979), 41(3), 343-57
Clinical, electrophysiological, histological and neuroendocrinological findings in a peculiar form of progressive spinal and bulbar muscular atrophy affecting 4 members in two different families are ... [more ▼]
Clinical, electrophysiological, histological and neuroendocrinological findings in a peculiar form of progressive spinal and bulbar muscular atrophy affecting 4 members in two different families are reported. The clinical hallmarks, which characterize this entity among the group of degenerative motor neuron diseases are: sex-linked recessive inheritance; onset in the third decade; slow progression; involvement of facial and bulbar muscles in addition to wasting of the proximal and, in some cases, the distal musculature; asymmetry of clinical signs; consistent and abundant fasciculations predominantly in the peri-oral muscles; intention tremor and a well-developed gynaecomastia, which is the first clinical sign. Electrophysiological and histological findings confirm the neurogenic origin of the muscular atrophy; in addition, muscle biopsy shows "myopathic-like" changes in one case and serum muscle enzyme levels are elevated in all neurologically affected patients. It is believed that the clinical entity corresponds to the rare type III proximal hereditary motor neuropathy (or "Kennedy's disease"), of which 25 published cases are reviewed. Neuroendocrinological data in two patients demonstrate an androgenic insufficiency of hypothalamo-hypophyseal origin and high levels of circulating oestrogens, which probably have induced gynaecomastia. Dynamic neuroendocrinological tests suggest that lesions of certain hypothalamic nuclei may exist, which should be looked for in the forthcoming anatomical studies. [less ▲]Detailed reference viewed: 86 (2 ULg)
Non-hypertrophic familial neuropathy associated with intention tremor. A variety of Charcot-Marie-Tooth disease?
; Schoenen, Jean
in Journal of the Neurological Sciences (1976), 27(1), 59-69
A family with an association of sensorimotor neuropathy and intention tremor is reported. Clinical examination of 3 affected family members showed in varying degrees areflexia, muscle wasting, impairment ... [more ▼]
A family with an association of sensorimotor neuropathy and intention tremor is reported. Clinical examination of 3 affected family members showed in varying degrees areflexia, muscle wasting, impairment of deep sensation with an ataxic gait, pes cavus and disabling intention tremor. Motor nerve conduction velocities were moderately slowed. A superficial peroneal nerve biopsy showed axonal degeneration without segmental demyelination or onion bulb formation. Our observation seems to indicate an association of intention tremor with the non-hypertrophic variety of Charcot-Marie-Tooth disease. It can therefore be suggested that the two classical types of Charcot-Marie-Tooth syndrome possess variants which are associated with intention tremor. This association is well-known for the hypertrophic type; our report gives an example of the non-hypertrophic type. [less ▲]Detailed reference viewed: 14 (0 ULg)