  Effect of fish oil supplementation in a model of a feline asthma; Leemans, Jérôme  ; et alin Acta Physiologica (2008), 192(662 Suppl), 10 Detailed reference viewed: 37 (4 ULg) Inhaled fluticasone reduces bronchial responsiveness and airway inflammation in cats with mild chronic bronchitis; ; et al in Journal of Feline Medicine and Surgery (2006), 8 This study investigated the effect of inhaled fluticasone on lower airway inflammation and bronchial responsiveness (BR) to inhaled carbachol in cats with very mild, chronic bronchitis (n = 5) that were ... [more ▼] This study investigated the effect of inhaled fluticasone on lower airway inflammation and bronchial responsiveness (BR) to inhaled carbachol in cats with very mild, chronic bronchitis (n = 5) that were compared with healthy cats serving as controls (n = 6). Chest radiographs, BR tests performed non-invasively by barometric whole body plethysmography (BWBP) and bronchoalveolar lavage (BAL) were performed before and after treatment. BR was quantified by calculating the concentration of carbachol inducing bronchoconstriction (C-Penh300%), defined as a 300% increase of baseline Penh, an index of bronchoconstriction obtained by BWBP. BAL fluid was analyzed cytologically and the oxidant marker 8-iso-PGF2α was determined. At test 1, healthy cats and cats with bronchitis were untreated, whereas for test 2 inhalant fluticasone (250 μg once daily) was administrated for 2 consecutive weeks to cats with bronchitis. Control cats remained untreated. Inhaled fluticasone induced a significant increase in C-Penh300% and a significant decrease of BAL fluid total cells, macrophages, neutrophils and 8-iso-PGF2α in cats with bronchitis, whilst untreated control cats did not show significant changes over time. This study shows that a 2-week fluticasone treatment significantly reduced lower airway inflammation in very mild bronchitis. BR could be successfully monitored in cats using BWPB and decreased significantly in response to inhaled fluticasone. 8-Iso-PGF2α in BAL fluid was responsive to treatment and appeared as a sensitive biomarker of lower airway inflammation in cats. [less ▲] Detailed reference viewed: 7 (1 ULg)Effect of water intake on dietary mannitol, sodium chloride and food frequency in healthy cats; ; et al in Proceedings of the 10th Congress ESVCN (2006) Detailed reference viewed: 5 (0 ULg)Omega 3 fatty acid complementation (fish oil) in an experimental model of feline asthma : effect on bronchial reactivity, airway inflammation and oxidative stress markers; Leemans, Jérôme ; et alin Proceedings: 24th Symposium of the Veterinary Comparative Respiratory Society,”Respiratory infections and zoonoses (2006) Detailed reference viewed: 14 (1 ULg)Diagnostic impact of thoracic radiography in an experimental model of feline asthma; ; Leemans, Jérôme et alin Proceedings: 24th Symposium of the Veterinary Comparative Respiratory Society,”Respiratory infections and zoonoses" (2006) Detailed reference viewed: 15 (0 ULg)Effect of omega-3 fatty acid supplementation (fish oil) on bronchial reactivity, airway inflammation and oxidative stress markers in a feline model of asthma; Leemans, Jérôme ; et alin Proceedings: 16th Congress European College of Veterinary Internal Medicine – companion animals (2006) Detailed reference viewed: 16 (1 ULg)Effect of water intake of dietary mannitol, sodium chloride and foot frequency in healthy cats; ; Leemans, Jérôme et alin Proceedings: 10th Congress of the European Society of Veterinary and Comparative Nutrition (2006) Detailed reference viewed: 6 (0 ULg)Effects of feeding frequency on water intake in cats; ; et al in Journal of Veterinary Internal Medicine (2005, May) Detailed reference viewed: 129 (0 ULg)Prednisolone reduces 8-Iso-PGF2alpha in a feline model of asthma; Leemans, Jérôme ; et alin European Respiratory Journal (2005), 137s Detailed reference viewed: 20 (3 ULg)Water intake is influenced by feeding frequency and energy allowance in cats; ; et al in Proceedings of the 9th Congress ESVCN (2005) Detailed reference viewed: 4 (1 ULg)Comparison of bronchodilators in feline airways: In vitro and in vivo investigationsLeemans, Jérôme ; ; et alin In proceedings: 15th Congress European College of Veterinary Internal Medicine – companion animals (2005) Detailed reference viewed: 10 (3 ULg)Evaluation of the bronchoprotective effects of inhaled salmeterol, fenoterol and oxitropium in healthy cats; Leemans, Jérôme ; et alin Fundamental & Clinical Pharmacology (2005), 19 Detailed reference viewed: 7 (1 ULg)MMP-9 activity and 8-ISO-PGF2alphaare increased in bronchoalveolar lavage fluid in a model of feline asthma; Leemans, Jérôme ; et alin Proceedings of the American College of Veterinary Internal Medicine, Baltimore, Maryland (2005) Detailed reference viewed: 11 (1 ULg)In vitro and in vivo effects of salbutamol acetonide on cat airwaysLeemans, Jérôme ; ; et alin Proceedings: Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques (2005) Detailed reference viewed: 12 (3 ULg)Repeatability of allergen challenges in a feline model of asthma : effect on airway reactivity and airway inflammation; Leemans, Jérôme ; et alin Proceedings of the American Thoracic Society, San Diego, California (2005) Detailed reference viewed: 5 (0 ULg)In vitro pharmacological activity of salbutamol acetonide on the isolated guinea-pig trachea and porcine bronchusLeemans, Jérôme ; ; et alin Fundamental & Clinical Pharmacology (2005), 19 Detailed reference viewed: 14 (6 ULg)Whole body barometric plethysmography: a screening method to investigate airway reactivity and acute lung injuries in freely moving pigs; ; et al in Veterinary Journal (2004), 168 The aim of this work was to investigate whether the Penh index, measured using whoie body barometric piethysmography, can be used as a screening parameter to evaluate the airway reactivity and the ... [more ▼] The aim of this work was to investigate whether the Penh index, measured using whoie body barometric piethysmography, can be used as a screening parameter to evaluate the airway reactivity and the intensity of the pulmonary response to endotoxins. Penh was firstly recorded in non-sedated freeiy moving piglets exposed (1) to a nebulized acetylchoiine (Ach) pre-treated or not with cienbuterol, or (2) to endotoxin challenge. To measure Penh simultaneously with total pulmonary resistance (RL), dynamic compliance (cd1) and intrapleural pressure changes (MaxPpl), an oesophageal balloon catheter technique was used and the piglets were anaesthetised. The recordings were performed during (1) an intravenous metacholine (Mch) challenge and (2) in endotoxin-exposed animais. In freely moving animais, Ach induced a significant dose-dependent increase in Penh, which was significantly blocked by clenbuterol. Endotoxin instillation aiso resulted in a significant rise in Penh while the corresponding response measured under anaesthesia was signiflcantly and positively correlated with RL and MaxzPpi. Similar results were obtained during Mch challenge but the Penh was negatively correlated with Cd. We conclude that Penh could be used in freely moving piglets as a screening index for airway reactivity and pulmonary functional changes in cholinergic and endotoxin challenges [less ▲] Detailed reference viewed: 37 (1 ULg)Cadmium-induced oxidative stress and lung emphysema in rats; ; et al in Prostaglandins, Leukotrienes, and Essential Fatty Acids (2004), 71 Detailed reference viewed: 6 (0 ULg) |
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