References of "Deconinck, Eric"
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See detailAnalytical strategies for the detection of counterfeit erectile dysfunction drugs.
Sacre, Pierre-Yves ULg; Deconinck, Eric; De Beer, Jacques

in Wang, Perry; Wertheimer, Albert (Eds.) Counterfeit Medicines Volume II: Detection, Identification and Analysis (in press)

Among all classes of drugs, the type 5 phosphodiesterase inhibitors (PDE5-i) (sildenafil, vardenafil and tadalafil) are the most counterfeited and copied in industrialized countries. This is why it is ... [more ▼]

Among all classes of drugs, the type 5 phosphodiesterase inhibitors (PDE5-i) (sildenafil, vardenafil and tadalafil) are the most counterfeited and copied in industrialized countries. This is why it is very important for regulatory agencies to have a panel of analytical methods to analyse these drugs and to be able to detect counterfeit or substandard medicines. During this chapter, several analytical techniques will be described and discussed. Among spectroscopic techniques, Raman, NIR, FT-IR and chemical imaging techniques will be envisaged. Their ability to detect counterfeits and predict if a new sample is genuine or not will be presented. Other techniques such as XRay powder diffraction and NMR spectroscopies will be briefly presented. Chromatographic impurity fingerprints will be considered and described for the analysis of suspect samples of Cialis® and Viagra®. Once again, the possibility to predict the authenticity of a new sample by the mean of this technique is envisaged. Finally, a MS-compatible UHPLC-UV method for the analysis of the three authorised PDE5-i and some of their analogues will be shortly described. This technique has been validated using spiked placebo samples in a vegetal matrix representing a suspect sample with a complex matrix. As a conclusion, a generic strategy for the detection and quality evaluation of counterfeit drugs will be presented. [less ▲]

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See detailStratégies analytiques pour la détection de contrefaçons de médicaments pour la dysfonction érectile
Sacre, Pierre-Yves ULg; Deconinck, Eric; Marini Djang'Eing'A, Roland ULg et al

in Spectra Analyse (2014), 43

Erectile dysfunction drugs are among the most counterfeit drug classes in industrialized countries. To fight against this plague, several analytical approaches are available for control laboratories. The ... [more ▼]

Erectile dysfunction drugs are among the most counterfeit drug classes in industrialized countries. To fight against this plague, several analytical approaches are available for control laboratories. The present article reviews the main used techniques and concludes presenting a general strategy for the detection and handling of drug counterfeits. [less ▲]

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See detailEvaluation of the residual solvent content of counterfeit tablets and capsules
Deconinck, Eric; Canfyn, Michael; Sacre, Pierre-Yves ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (2013), 81-82

A group of counterfeit samples of Viagra® and Cialis® were screened for their residual solvent content and compared to the content of the genuine products. It was observed that all counterfeit samples had ... [more ▼]

A group of counterfeit samples of Viagra® and Cialis® were screened for their residual solvent content and compared to the content of the genuine products. It was observed that all counterfeit samples had higher residual solvent contents compared to the genuine products. A more diverse range of residual solvents was found as well as higher concentrations. In general these concentrations did not exceed the international imposed maximum limits. Only in a few samples the limits were exceeded. A Projection Pursuit analysis revealed clusters of samples with similar residual solvent content, possibly enabling some future perspectives in forensic research. [less ▲]

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See detailChromatography in the detection and characterisation of illegal pharmaceutical preparations
Deconinck, Eric; Sacre, Pierre-Yves ULg; Courselle, Patricia et al

in Journal of Chromatographic Science (2013), 51(8), 791-806

Counterfeit and illegal pharmaceutical products are an increasing worldwide problem and constitute a major challenge for analytical laboratories to detect and characterize them. Spectroscopic techniques ... [more ▼]

Counterfeit and illegal pharmaceutical products are an increasing worldwide problem and constitute a major challenge for analytical laboratories to detect and characterize them. Spectroscopic techniques as infrared spectroscopy and Raman spectroscopy were always the first methods of choice to detect counterfeits and illegal preparations, but due to the evolution in the products seized and the necessity of risk assessment, chromatographic methods are becoming more important in this domain. This review intends to give a general overview of the techniques described in literature to characterize counterfeit and illegal pharmaceutical preparations, focussing on the role of chromatographic techniques, with different detection tools. [less ▲]

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See detailAllogeneic stem cell transplantation for chronic myelomonocytic leukemia : a report from the Société Française de Greffe de Moelle et de Thérapie Cellulaire
Park, Sophie; Labopin, Myriam; Yakoub-Agha, Ibrahim et al

in European Journal of Haematology (2013), 90

Objectives and methods: Chronic myelomonocytic leukemia (CMML) is a severe disease for which allogeneic stem cell transplantation (allo-SCT) remains the only potentially curative treatment. We describe a ... [more ▼]

Objectives and methods: Chronic myelomonocytic leukemia (CMML) is a severe disease for which allogeneic stem cell transplantation (allo-SCT) remains the only potentially curative treatment. We describe a retrospective study determining prognostic factors for outcome after allo-SCT in consecutive 73 patients with CMML reported to the SFGM-TC registry between 1992 and 2009. Results: At diagnosis, median age was 53 yrs, and 36% patients had palpable splenomegaly (SPM). 48, 13, and 9 patients had good, intermediate, and poor risk karyotype, respectively, according to IPSS, 61% patients had CMML-1, and 39% had CMML-2. 41/31/1 cases had an HLA-identical sibling, an unrelated and haploidentical donor, respectively. 43 patients received reduced-intensity conditioning. With a median follow-up of 23 month, acute grade 2–4 and chronic GVHD developed in 21 and 25 patients, respectively. The 3-year OS, NRM (non-relapse mortality),EFS, and CIR (cumulative incidence of relapse) were 32%, 36%, 29% and 35%, respectively. OS was not influenced by the CR status, marrow blasts% at allo-SCT, prior treatments, and cGVHD. Using multivariate analysis, year of transplant < 2004 (YOT) (P = 0.005) was associated with higher NRM, YOT < 2004 (P = 0.04) and SPM at allo-SCT (P = 0.02) with lower EFS, and YOT < 2004 (P = 0.03) and SPM at allo-SCT (P = 0.04) with poorer OS. Conclusions: Allogeneic stem cell transplantation is a valid treatment option for patients with CMML, and its outcome has improved with YOT > 2004. Splenomegaly seems to be a negative factor of OS and EFS in this series. [less ▲]

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See detailA validated GC-MS method for the determination and quantification of residual solvents in counterfeit tablets and capsules
Deconinck, Eric; Canfyn, Michaël; Sacre, Pierre-Yves ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (2012), 70

A fast headspace GC-MS method was developed and validated for the detection and quantification of residual solvents of all three ICH-classes in counterfeit tablets and capsules. The method was validated ... [more ▼]

A fast headspace GC-MS method was developed and validated for the detection and quantification of residual solvents of all three ICH-classes in counterfeit tablets and capsules. The method was validated for ten solvents, selected based on an initial screening of counterfeit medicinal products. The considered solvents were ethanol, 2-propanol, acetone, ethylacetate, chloroform, carbon tetrachloride, benzene, toluene, dichloromethane and ethylbenzene. The proposed method uses a Phenomenex 624 capillary column (60 m x 0.32 mm; 1.8 µm film thickness) (Phenomenex, Torrance, USA) with an oven temperature program from 60°C (held for 5 min) to 270°C at 25 °C/min. 270°C is held for 10 min. The total run time is 23.4 minutes. The obtained method was fully validated by applying the “total error” profile. Calibration lines for all components were linear within the studied ranges. The relative bias and the relative standard deviations for all components were smaller than 5%, the -expectation tolerance limits did not exceed the acceptance limits of 10% and the relative expanded uncertainties were acceptable for all of the considered components. A method was obtained for the screening and quantification of residual solvents in counterfeit tablets and capsules, which will allow a fast screening of these products for the presence of residual solvents. [less ▲]

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See detailChemometrics and chromatographic fingerprints to discriminate and classify counterfeit medicines containing PDE-5 inhibitors.
Deconinck, Eric; Sacre, Pierre-Yves ULg; Courselle, Patricia et al

in Talanta (2012), 100

Chromatographic fingerprints recorded for a set of genuine and counterfeit samples of Viagra® and Cialis® were evaluated for their use in the detection and classification of counterfeit samples of these ... [more ▼]

Chromatographic fingerprints recorded for a set of genuine and counterfeit samples of Viagra® and Cialis® were evaluated for their use in the detection and classification of counterfeit samples of these groups of medicines. Therefore several exploratory chemometric techniques were applied to reveal structures in the data sets as well as differences among the samples. The focus was on the differentiation between genuine and counterfeit samples and on the differences between the samples of the different classes of counterfeits as defined by the Dutch National Institute for Public Health and the Environment (RIVM). In a second part the revealed differences between the samples were modelled to obtain a predictive model for both the differentiation between genuine and counterfeit samples as well as the classification of the counterfeit samples. The exploratory analysis clearly revealed differences in the data for the genuine and the counterfeit samples and with projection pursuit and hierarchical clustering differences among the different groups of counterfeits could be revealed, especially for the Viagra® data set. For both data sets predictive models were obtained with 100% correct classification rates for the differentiation between genuine and counterfeit medicines and high correct classification rates for the classification in the different classes of counterfeit medicines. For both data sets the best performing models were obtained with Least Square-Support Vector Machines (LS-SVM) and Soft Independent Modelling by Class Analogy (SIMCA). [less ▲]

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See detailImpact of Azacitidine before allogeneic stem-cell transplantation for myelodysplastic syndromes : a study b the Société Française de Greffe de Moelle et de Thérapie-Cellulaire and the Groupe Francophone des Myélodysplasies
Damaj, Gandhi; Duhamel, Alain; Robin, Marie et al

in Journal of Clinical Oncology (2012), 30

Purpose : To investigate the impact of prior-to-transplantation azacitidine (AZA) on patient outcome after allogeneic stem-cell transplantation (alloSCT) for myelodysplastic syndrome (MDS). Patients and ... [more ▼]

Purpose : To investigate the impact of prior-to-transplantation azacitidine (AZA) on patient outcome after allogeneic stem-cell transplantation (alloSCT) for myelodysplastic syndrome (MDS). Patients and Methods Of the 265 consecutive patients who underwent alloSCT for MDS between October 2005 and December 2009, 163 had received cytoreductive treatment prior to transplantation, including induction chemotherapy (ICT) alone (ICT group; n 98), AZA alone (AZA group; n 48), or AZA preceded or followed by ICT (AZA-ICT group; n 17). At diagnosis, 126 patients (77%) had an excess of marrow blasts, and 95 patients (58%) had intermediate-2 or high-risk MDS according to the International Prognostic Scoring System (IPSS). Progression to more advanced disease before alloSCT was recorded in 67 patients. Donors were sibling (n 75) or HLA-matched unrelated (10/10; n 88). They received blood (n 142) or marrow (n 21) grafts following either myeloablative (n 33) or reduced intensity (n 130) conditioning. Results : With a median follow-up of 38.7 months, 3-year outcomes in the AZA, ICT, and AZA-ICT groups were 55%, 48%, and 32% (P .07) for overall survival (OS); 42%, 44%, and 29% (P .14) for event-free survival (EFS); 40%, 37%, and 36% (P .86) for relapse; and 19%, 20%, and 35% (P .24) for nonrelapse mortality (NRM), respectively. Multivariate analysis confirmed the absence of statistical differences between the AZA and the ICT groups in terms of OS, EFS, relapse, and NRM. Conclusion : With the goal of downstaging underlying disease before alloSCT, AZA alone led to outcomes similar to those for standard ICT. [less ▲]

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See detailClassification Trees based on infrared spectroscopic data to discriminate between genuine and counterfeit medicines.
Deconinck, Eric; Sacre, Pierre-Yves ULg; Coomans, Danny et al

Poster (2012)

Due to the extension of the internet, counterfeit drugs represent a growing threat for public health in the developing countries but also more and more in the industrial world. In literature several ... [more ▼]

Due to the extension of the internet, counterfeit drugs represent a growing threat for public health in the developing countries but also more and more in the industrial world. In literature several analytical techniques were applied in order to discriminate between genuine and counterfeit medecines. One thing all these techniques have in common is that they generate a huge amount of data, which is often difficult to interpret in order to see differences between the different samples and to determine the cause of the differences. The majority of the authors make use of explorative chemometric tools to visualise the differences in the data obtained for the different samples. Even if some of the applied methods could be able to give a model with predictive ability, only a few authors created a model able to predict if a sample is counterfeit or not. Classification trees built with the Classification And Regression Tree algorithm were evaluated for modelling infrared spectroscopic data in order to discriminate between genuine and counterfeit drug samples and to classify counterfeit samples in different classes following the RIVM classification system. Models were built for two data sets consisting of the Fourrier Transformed Infrared spectra, the Near Infrared spectra and the Raman spectra for genuine and counterfeit samples of respectively Viagra® and Cialis®. Easy interpretable models were obtained for both models. The models were validated for their descriptive and predictive properties. The predictive properties were evaluated using both cross validation as an external validation set. The obtained models for both data sets showed a 100% correct classification for the discrimination between genuine and counterfeit samples and 83.3% and 100% correct classification for the counterfeit samples for the Viagra® and the Cialis® data set respectively. [less ▲]

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See detailClassification trees based on infrared spectroscopic data to discriminate between genuine and counterfeit medicines
Deconinck, Eric; Sacré, Pierre-Yves ULg; Coomans, Danny et al

in Journal of Pharmaceutical & Biomedical Analysis (2012), 57(1), 68-75

Classification trees built with the Classification And Regression Tree algorithm were evaluated for modelling infrared spectroscopic data in order to discriminate between genuine and counterfeit drug ... [more ▼]

Classification trees built with the Classification And Regression Tree algorithm were evaluated for modelling infrared spectroscopic data in order to discriminate between genuine and counterfeit drug samples and to classify counterfeit samples in different classes following the RIVM classification system. Models were built for two data sets consisting of the Fourrier Transformed Infrared spectra, the Near Infrared spectra and the Raman spectra for genuine and counterfeit samples of respectively Viagra® and Cialis®. Easy interpretable models were obtained for both models. The models were validated for their descriptive and predictive properties. The predictive properties were evaluated using both cross validation as an external validation set. The obtained models for both data sets showed a 100% correct classification for the discrimination between genuine and counterfeit samples and 83.3% and 100% correct classification for the counterfeit samples for the Viagra® and the Cialis® data set respectively. [less ▲]

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See detailClassification trees based on infrared spectroscopic data to discriminate between genuine and counterfeit medecines
Deconinck, Eric; Sacré, Pierre-Yves ULg; De Beer, Jacques

Conference (2011, September 23)

Classification trees built with the Classification And Regression Tree algorithm were evaluated for modelling infrared spectroscopic data in order to discriminate between genuine and counterfeit drug ... [more ▼]

Classification trees built with the Classification And Regression Tree algorithm were evaluated for modelling infrared spectroscopic data in order to discriminate between genuine and counterfeit drug samples and to classify counterfeit samples in different classes following the RIVM classification system. Models were built for two data sets consisting of the Fourier Transform Infrared spectra, the Near Infrared spectra and the Raman spectra for genuine and counterfeit samples of respectively Viagra® and Cialis®. Easy interpretable models were obtained for both models. The models were validated for their descriptive and predictive properties. The predictive properties were evaluated using both cross validation as an external validation set. The obtained models for both data sets showed a 100% correct classification for the discrimination between genuine and counterfeit samples and 83.3% and 100% correct classification for the counterfeit samples for the Viagra® and the Cialis® data set respectively. [less ▲]

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See detailImpurity fingerprints for the identification of counterfeit medicines - a feasibility study
Sacré, Pierre-Yves ULg; Deconinck, Eric; Daszykowski, Michal et al

Poster (2011, September)

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See detailImpurity fingerprints for the identification of counterfeit medicines - a feasibility study
Sacré, Pierre-Yves ULg; deconinck, Eric; Daszykowski, Michal et al

Poster (2011, June 22)

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See detailDetection of counterfeit Viagra by Raman microspectroscopy imaging and multivariate analysis
Sacré, Pierre-Yves ULg; Deconinck, Eric; Saerens, Lien et al

Conference (2011, May 13)

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See detailIncreased risk of non-Hodgkin lymphoma and serum organochlorine concentrations among neighbors of a municipal solid waste incinerator
Viel, Jean-François; Floret, Nathalie; Deconinck, Eric et al

in Environment International (2011), 37(2), 449-453

Organochlorine chemicals may contribute to an increased risk of non-Hodgkin lymphoma (NHL) within nonoccupationally exposed populations. Among these chemicals, dioxins and furans were mainly released by ... [more ▼]

Organochlorine chemicals may contribute to an increased risk of non-Hodgkin lymphoma (NHL) within nonoccupationally exposed populations. Among these chemicals, dioxins and furans were mainly released by municipal solid waste incinerators (MSWIs) until a recent past in France, a source of exposure that is of public concern. We investigated organochlorines and the risk of NHL among neighbors of a French MSWI with high levels of dioxin emissions (Besançon, France), using serum concentrations to assess exposure. The study area consisted of three electoral wards, containing or surrounding the MSWI. Pesticides, dioxins, furans, and polychlorinated biphenyls (PCBs) were measured in the serum of 34 newly diagnosed NHL cases (2003– 2005) and 34 controls. Risks of NHL associated with each lipid-corrected serum concentration were estimated using exact logistic regression. The pesticides β-hexachlorocyclohexane (odds ratio [OR]=1.05, 95% confidence interval [CI]=1.00–1.12, per 10 ng/g lipid) and p,p' dichloro-diphenyl-trichloroethane (DDT) (OR=1.20, 95% CI=1.01-1.45, per 10 ng/g lipid) were associated with NHL risk. Evidence indicated an increased NHL risk associated with cumulative WHO1998-toxic equivalency factor (TEQ) concentrations (dioxins, OR=1.12, 95% CI=1.03–1.26; furans, OR=1.16, 95% CI=1.03–1.35; dioxin-like PCBs, OR=1.04, 95% CI=1.00–1.07; and total TEQ, OR=1.04, 95% CI=1.01–1.05), as well as with non dioxin-like PCBs (OR=1.02, 95% CI=1.01–1.05, per 10 ng/g lipid). Most congener-specific associations were statistically significant. This study provides strong and consistent support for an association between serum cumulative WHO1998-TEQ concentrations, at levels experienced by people residing in the vicinity of a polluting MSWI, and risk of NHL. [less ▲]

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See detailDetection of counterfeit Viagra® by Raman Microspectroscopy imaging and multivariate analysis.
Sacré, Pierre-Yves ULg; Deconinck, Eric; Saerens, Lien et al

in Journal of Pharmaceutical & Biomedical Analysis (2011), 56

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See detailDevelopment and validation of a ultra-high-performance liquid chromatography-UV method for the detection and quantification of erectile dysfunction drugs and some of their analogues found in counterfeit medicines
Sacré, Pierre-Yves ULg; Deconinck, Eric; Chiap, Patrice ULg et al

in Journal of Chromatography. A (2011), 1218

Pharmaceutical counterfeiting is a permanently growing problem. Control laboratories are constantly analysing counterfeit medicines. In industrialised countries, one of the main counterfeited class of ... [more ▼]

Pharmaceutical counterfeiting is a permanently growing problem. Control laboratories are constantly analysing counterfeit medicines. In industrialised countries, one of the main counterfeited class of medicines are erectile dysfunction drugs. This paper describes the development and validation of a fast method to detect and quantify the three authorised phosphodiesterase type 5 inhibitors and five analogues. The method is based on the use of a sub-2 microns polar-embedded column with a gradient using acetonitrile as organic modifier and 10 mM ammonium formate buffer (pH 3.5) as aqueous component of the mobile phase. The separation was achieved in less than 4.5 min. The method has also been compared to the registered HPLC method for the assay of Viagra® which was considered as the reference method. The method is also compatible with on-line coupling mass spectrometry and will significantly reduce analysis times and solvent consumption. [less ▲]

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See detailImpurity fingerprints for the identification of counterfeit medicines - a feasibility study
Sacré, Pierre-Yves ULg; Deconinck, Eric; Daszykowski, Michal et al

in Analytica Chimica Acta (2011), 701

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