Nouveaux développements dans le domaine des analogues pyridiniques du nimésulide présentant un pont « inter-cycle » aminé

Poster (2006, June)

Structure-based pharmacophore of COX-2 selective inhibitors and identification of original lead compounds from 3D database searching method

in European Journal of Medicinal Chemistry (2006), 41

A new potential cyclooxygenase-2 inhibitor, pyridinic analogue of nimesulide

in European Journal of Medicinal Chemistry (2005), 40

Modulation of the arachidonic cascade with omega 3 fatty acids or analogues: Potential therapeutic benefits

in Mini-Reviews in Medicinal Chemistry (2004), 4(6), 659-668

Increasing interest in the role of omega 3 fatty acids has arisen in these latest years since evidence of their implication in the cardioprotective fish based diet of the Inuit has been demonstrated ... [more ▼]

Increasing interest in the role of omega 3 fatty acids has arisen in these latest years since evidence of their implication in the cardioprotective fish based diet of the Inuit has been demonstrated. Furthermore, several in vitro, in vivo and epidemiological studies support the benefit of this fatty acids intake in various pathological states such as in the cardiovascular, cancer, inflammation, psychiatric, paediatric, pulmonary, dermatological and ophthalmologic fields. This review will focus on metabolism and pharmacological implication of w3 fatty acids intake as well as its interest in the prevention or treatment of the above-mentioned pathologies. [less ▲]

Identification d’un inhibiteur COX-2 sélectif », 18èmes Journées Franco-belges de Pharmacochimie

Poster (2004, June)

Synthèse et évaluation pharmacologique d’analogues pyridiniques du nimésulide : variation du pont « inter-cycle

Poster (2004, June)

Effects of COX-2 inhibitors on ROS produced by Chlamydia pneumoniae-primed human promonocytic cells (THP-1)

in Biochemical and Biophysical Research Communications (2004), 325(4), 1122-1130

Chronic inflammation through foam cells and macrophages is important in atherosclerosis development, and can be considered as therapeutic targets. Cyclooxygenase and NADPH-oxidase were expressed within ... [more ▼]

Chronic inflammation through foam cells and macrophages is important in atherosclerosis development, and can be considered as therapeutic targets. Cyclooxygenase and NADPH-oxidase were expressed within atherosclerotic lesions. Reactive oxygen species produced by NADPH oxidase were found to trigger the cyclooxygenase-2 expression. The effects of preferential COX-2 inhibitors on ROS produced by Chlamydia-primed human monocytes (THP-1 cells) were evaluated by fluorescence, chemiluminescence, oxymetry, and EPR spin trapping. Fluorescence assays showed an increased production of ROS with Chlamydia versus cells primed by 10(-8) M PMA. COX-2 inhibitors inhibited in a dose-dependent manner the luminol-enhanced CL while ibuprofen and diclofenac increased the chemiluminescence response. By EPR spin trapping, COX-2 inhibitors, ibuprofen, and diclofenac, exhibited a dose-dependent inhibiting effect (10 and 100 muM) on the EPR signal appearance. Our cell model combining EPR, chemiluminescence, and oxymetry appeared relevant to study the modulating effects of preferential COX-2 inhibitors on the cell oxidant activity and chronic inflammatory diseases. (C) 2004 Elsevier Inc. All rights reserved. [less ▲]

First and second generations of COX-2 selective inhibitors

in Mini Reviews in Medicinal Chemistry (2004), 4

Modulation of the arachidonic cascade with omega3 fatty acids or analogues: potential therapeutic benefits

in Mini Reviews in Medicinal Chemistry (2004), 4

Progress in the field of GPIIb/IIIa antagonists

in Current Medicinal Chemistry - Cardiovascular and Hematological Agents (2004), 2