References of "Dauby, Pierre"
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See detailModel-based computation of total stressed blood volume from a preload reduction manoeuvre
Pironet, Antoine ULg; Desaive, Thomas ULg; Chase, J. Geoffrey et al

in Mathematical Biosciences (2015), 265(0), 28-39

Total stressed blood volume is an important parameter for both doctors and engineers. From a medical point of view, it has been associated with the success or failure of fluid therapy, a primary treatment ... [more ▼]

Total stressed blood volume is an important parameter for both doctors and engineers. From a medical point of view, it has been associated with the success or failure of fluid therapy, a primary treatment to manage acute circulatory failure. From an engineering point of view, it dictates the cardiovascular system’s behavior in changing physiological situations. Current methods to determine this parameter involve repeated phases of circulatory arrests followed by fluid administration. In this work, a more straightforward method is developed using data from a preload reduction manoeuvre. A simple six-chamber cardiovascular system model is used and its parameters are adjusted to pig experimental data. The parameter adjustment process has three steps: (1) compute nominal values for all model parameters; (2) determine the five most sensitive parameters; and (3) adjust only these five parameters. Stressed blood volume was selected by the algorithm, which emphasizes the importance of this parameter. The model was able to track experimental trends with a maximal root mean squared error of 29.2%. Computed stressed blood volume equals 486 ± 117 ml or 15.7 ± 3.6 ml/kg, which matches previous independent experiments on pigs, dogs and humans. The method proposed in this work thus provides a simple way to compute total stressed blood volume from usual hemodynamic data. [less ▲]

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See detailMultiscale model of the human cardiovascular system: healthy and pathological behaviours
Kosta, Sarah ULg; Negroni, Jorge; Lascano, Elena et al

Poster (2015, May 13)

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See detailImportance of wavenumber dependence of Biot numbers in one-sided models of evaporative Marangoni instability: horizontal layer and spherical droplet
Machrafi, Hatim ULg; Rednikov, Alexey; Colinet, Pierre et al

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2015)

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See detailRelation between global end-diastolic volume and left ventricular end-diastolic volume
Pironet, Antoine ULg; MORIMONT, Philippe ULg; Kamoi, S. et al

in Critical Care (2015), 19(Suppl 1), 175

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See detailTracking stressed blood volume during vascular filling experiments
Pironet, Antoine ULg; Dauby, Pierre ULg; Chase, J. Geoffrey et al

in 13th Belgian Day on Biomedical Engineering (2014, November 28)

A three-chamber cardiovascular system model is used to compute stressed blood volume from filling experiments. As previously observed, stressed blood volume is a good predictor of the change in cardiac ... [more ▼]

A three-chamber cardiovascular system model is used to compute stressed blood volume from filling experiments. As previously observed, stressed blood volume is a good predictor of the change in cardiac output after fluid infusion. [less ▲]

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See detailTracking stressed blood volume during vascular filling experiments
Pironet, Antoine ULg; Dauby, Pierre ULg; Chase, J. Geoffrey et al

Poster (2014, November 28)

A three-chamber cardiovascular system model is used to compute stressed blood volume from filling experiments. As previously observed, stressed blood volume is a good predictor of the change in cardiac ... [more ▼]

A three-chamber cardiovascular system model is used to compute stressed blood volume from filling experiments. As previously observed, stressed blood volume is a good predictor of the change in cardiac output after fluid infusion. [less ▲]

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See detailModeling of the cardio-pulmonary system assisted by ECMO
Habran, Simon ULg; Dauby, Pierre ULg; Desaive, Thomas ULg et al

in National Day on Biomedical Engineering 2014 (2014, October)

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See detailModel-Based Computation of Total Stressed Blood Volume from a Preload Reduction Experiment
Pironet, Antoine ULg; Desaive, Thomas ULg; Chase, J. Geoffrey et al

Conference (2014, August)

Total stressed blood volume is an important parameter for both doctors and engineers. From a medical point of view, it has been associated with the success or failure of fluid resuscitation therapy, which ... [more ▼]

Total stressed blood volume is an important parameter for both doctors and engineers. From a medical point of view, it has been associated with the success or failure of fluid resuscitation therapy, which is a treatment for cardiac failure. From an engineering point of view, this parameter dictates the cardiovascular system's dynamic behavior. Current methods to determine this parameter involve repeated phases of circulatory arrests followed by fluid administration. In this work, a method is developed to compute stressed blood volume from preload reduction experiments. A simple six-chamber cardiovascular system model is used and its parameters are adjusted to pig experimental data. The parameter adjustment process has three steps: (1) compute nominal values for all model parameters; (2) determine the most sensitive parameters; and (3) adjust only these sensitive parameters. Stressed blood volume was determined sensitive for all datasets, which emphasizes the importance of this parameter. The model was able to track experimental trends with a maximal mean squared error of 11.77 %. Stressed blood volume has been computed to range between 450 and 963 ml, or 15 to 28 ml/kg, which matches previous independent experiments on pigs, dogs and humans. Consequently, the method proposed in this work provides a simple way to compute total stressed blood volume from usual hemodynamic data. [less ▲]

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See detailStructural identifiability analysis of a cardiovascular system model
Pironet, Antoine ULg; Dauby, Pierre ULg; Chase, J. Geoffrey et al

Conference (2014, August)

A simple experimentally validated cardiovascular system model has been shown to be able to track the evolution of various diseases. The model has previously been made patient-specific by adjustment of its ... [more ▼]

A simple experimentally validated cardiovascular system model has been shown to be able to track the evolution of various diseases. The model has previously been made patient-specific by adjustment of its parameters on the basis of a minimal set of hemodynamic measurements. However, this model has not yet been shown to be structurally identifiable, which means that the adjusted model parameters may not be unique. The model equations were manipulated to show that, from a theoretical point of view, all of their parameters can be exactly retrieved from a restricted set of model outputs. However, this set of model outputs is still too large for a clinical application, because it includes left and right ventricular pressures. Consequently, further hypotheses that determine some model parameter values have to be made for the model to be clinically applicable. [less ▲]

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See detailStructural Identifiability Analysis of a Cardiovascular System Model
Pironet, Antoine ULg; Dauby, Pierre ULg; Chase, J. Geoffrey et al

in Preprints of the 19th World Congress (2014, August)

A simple experimentally validated cardiovascular system model has been shown to be able to track the evolution of various diseases. The model has previously been made patient-specific by adjustment of its ... [more ▼]

A simple experimentally validated cardiovascular system model has been shown to be able to track the evolution of various diseases. The model has previously been made patient-specific by adjustment of its parameters on the basis of a minimal set of hemodynamic measurements. However, this model has not yet been shown to be structurally identifiable, which means that the adjusted model parameters may not be unique. The model equations were manipulated to show that, from a theoretical point of view, all of their parameters can be exactly retrieved from a restricted set of model outputs. However, this set of model outputs is still too large for a clinical application, because it includes left and right ventricular pressures. Consequently, further hypotheses that determine some model parameter values have to be made for the model to be clinically applicable. [less ▲]

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See detailModel-Based Computation of Total Stressed Blood Volume from a Preload Reduction Experiment
Pironet, Antoine ULg; Desaive, Thomas ULg; Chase, J. Geofrrey et al

in Preprints of the 19th World Congress (2014, August)

Total stressed blood volume is an important parameter for both doctors and engineers. From a medical point of view, it has been associated with the success or failure of fluid resuscitation therapy, which ... [more ▼]

Total stressed blood volume is an important parameter for both doctors and engineers. From a medical point of view, it has been associated with the success or failure of fluid resuscitation therapy, which is a treatment for cardiac failure. From an engineering point of view, this parameter dictates the cardiovascular system’s dynamic behavior. Current methods to determine this parameter involve repeated phases of circulatory arrests followed by fluid administration. In this work, a method is developed to compute stressed blood volume from preload reduction experiments. A simple six-chamber cardiovascular system model is used and its parameters are adjusted to pig experimental data. The parameter adjustment process has three steps: (1) compute nominal values for all model parameters; (2) determine the most sensitive parameters; and (3) adjust only these sensitive parameters. Stressed blood volume was determined sensitive for all datasets, which emphasizes the importance of this parameter. The model was able to track experimental trends with a maximal mean squared error of 11.77 %. Stressed blood volume has been computed to range between 450 and 963 ml, or 15 to 28 ml/kg, which matches previous independent experiments on pigs, dogs and humans. Consequently, the method proposed in this work provides a simple way to compute total stressed blood volume from usual hemodynamic data. [less ▲]

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See detailRelation between convective thermal patterns and heat flux through an evaporating surface via 2D and 3D numerical simulations
Machrafi, Hatim ULg; Iorio, Carlo; Dauby, Pierre ULg

in Interfacial Phenomena and Heat Transfer (2014), 2(3), 199-209

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See detailMulti-scale model of the cardiovascular system
Kosta, Sarah ULg; Pironet, Antoine ULg; Negroni, Jorge et al

in 13th Belgian National Day on Biomedical Engineering (2014)

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See detailMulti-scale model of the cardiovascular system
Kosta, Sarah ULg; Pironet, Antoine ULg; Negroni, Jorge et al

Poster (2014)

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See detailSimulation of Left Atrial Function Using a Multi-Scale Model of the Cardiovascular System
Pironet, Antoine ULg; Dauby, Pierre ULg; Paeme, Sabine ULg et al

in PLoS ONE (2013), 8(6), 65146

During a full cardiac cycle, the left atrium successively behaves as a reservoir, a conduit and a pump. This complex behavior makes it unrealistic to apply the time-varying elastance theory to ... [more ▼]

During a full cardiac cycle, the left atrium successively behaves as a reservoir, a conduit and a pump. This complex behavior makes it unrealistic to apply the time-varying elastance theory to characterize the left atrium, first, because this theory has known limitations, and second, because it is still uncertain whether the load independence hypothesis holds. In this study, we aim to bypass this uncertainty by relying on another kind of mathematical model of the cardiac chambers. In the present work, we describe both the left atrium and the left ventricle with a multi-scale model. The multi-scale property of this model comes from the fact that pressure inside a cardiac chamber is derived from a model of the sarcomere behavior. Macroscopic model parameters are identified from reference dog hemodynamic data. The multi-scale model of the cardiovascular system including the left atrium is then simulated to show that the physiological roles of the left atrium are correctly reproduced. This include a biphasic pressure wave and an eight-shaped pressure-volume loop. We also test the validity of our model in non basal conditions by reproducing a preload reduction experiment by inferior vena cava occlusion with the model. We compute the variation of eight indices before and after this experiment and obtain the same variation as experimentally observed for seven out of the eight indices. In summary, the multi-scale mathematical model presented in this work is able to correctly account for the three roles of the left atrium and also exhibits a realistic left atrial pressure-volume loop. Furthermore, the model has been previously presented and validated for the left ventricle. This makes it a proper alternative to the time-varying elastance theory if the focus is set on precisely representing the left atrial and left ventricular behaviors. [less ▲]

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See detailAssessment of ventricular contractility and ventricular-arterial coupling with a model-based sensor.
Desaive, Thomas ULg; LAMBERMONT, Bernard ULg; JANSSEN, Nathalie ULg et al

in Computer Methods & Programs in Biomedicine (2013), 109(2),

Estimation of ventricular contractility and ventricular arterial coupling is clinically important in diagnosing and treating cardiac dysfunction in the critically ill. However, experimental assessment of ... [more ▼]

Estimation of ventricular contractility and ventricular arterial coupling is clinically important in diagnosing and treating cardiac dysfunction in the critically ill. However, experimental assessment of indexes of ventricular contractility, such as the end-systolic pressure-volume relationship, requires a highly invasive maneuver and measurements that are not typical in an intensive care unit (ICU). This research describes the use of a previously validated cardiovascular system model and parameter identification process to evaluate the right ventricular arterial coupling in septic shock. Model-based ventricular arterial coupling is defined by the ratio of the end systolic right ventricular elastance (E(esrvf)) over the pulmonary artery elastance (E(pa)) or the mean pulmonary inflow resistance (R(pulin)). Results are compared to the clinical gold-standard assessment (conductance catheter method). Six anesthetized healthy pigs weighing 20-30kg received a 0.5mgkg(-1) endotoxin infusion over a period of 30min from T0 to T30, to induce septic shock and veno-venous hemofiltration was used from T60 onward. The results show good agreement with the gold-standard experimental assessment. In particular, the model-based right ventricular elastance (E(esrvf)) correlates well with the clinical gold standard (R(2)=0.69) and the model-based non-invasive coupling (E(esrvf)/R(pulin)) follow the same trends and dynamics (R(2)=0.37). The overall results show the potential to develop a model-based sensor to monitor ventricular-arterial coupling in clinical real-time. [less ▲]

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