References of "DEROISY, Rita"
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See detailComparison of the effect of Platelet Rich Plasma (PRP) with Hyaluronic Acid (HA) injections to treat chronic Jumper's knee
Kaux, Jean-François ULiege; DEROISY, Rita ULiege; SAMSON, Antoine ULiege et al

in Journal of Rehabilitation Medicine (in press)

Introduction: Patellar Tendinopathies (PT) represent a very frequent disorder which incidence can reach 30-50% among jumping sports. This trouble is often rebel to classical treatment. Objective: To ... [more ▼]

Introduction: Patellar Tendinopathies (PT) represent a very frequent disorder which incidence can reach 30-50% among jumping sports. This trouble is often rebel to classical treatment. Objective: To compare the efficacy of a single injection of RPR to a double infiltration of HA at one week interval. Patients/Methods: Thirty-three patients suffering from PT were enrolled into the study and split into two randomized groups . Eighteen patients (Group 1) have received one PRP injection and the other fifteen subjects (Group 2) received two HA infiltrations. Pain and functionality of the knee were evaluated before injection (T0), 6 weeks (T2) and 3 months (T3) after injections: pain with VAS and pressure algometer, algofunctional scores with IKDC and VISA-P questionnaires, ultrasound, isokinetic evaluation (quadriceps contractions : concentric 60°/sec (C60), concentric 240°/sec (C240), excentric 30°/sec (E30) and VAS during testing). Results: At baseline, difference existed only between groups for algometer, tendon thickness and axial hypoechoic area. In both groups, VAS, algometer, IKCD, VISA-P, VAS for isokinetic testing C60, C240 and E30 were significantly improved at T2 and T3 compared to T0. Comparison between the 2 groups showed no difference excepted for algometer, tendon thickness (T2, T3) and axial hypoechoic area (T2). Discussion and conclusions: There existed a similar improvement of the symptoms in both groups. PRP has already shown its efficacy in PT. HA should probably be a new therapeutic opportunity in this indication. Nevertheless, it should better, for further studies, to include a more homogeneous population and a longer follow-up period of time. [less ▲]

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See detailThe role of diet and exercise and of glucosamine sulfate in the prevention of knee osteoarthritis: Further results from the PRevention of knee Osteoarthritis in Overweight Females (PROOF) study.
Runhaar, J.; DEROISY, Rita ULiege; van Middelkoop, M. et al

in Seminars in Arthritis & Rheumatism (2016), 45(4 Suppl), 42-48

Background and objectives: The PRevention of knee Osteoarthritis in Overweight Females(PROOF) study (ISRCTN42823086) described a trend for a decrease in the incidence of kneeo steoarthritis (OA) by a ... [more ▼]

Background and objectives: The PRevention of knee Osteoarthritis in Overweight Females(PROOF) study (ISRCTN42823086) described a trend for a decrease in the incidence of kneeo steoarthritis (OA) by a tailored diet and exercise program (DEP)or by oral glucosamine sulfate in women at risk for the disease, using a composite clinical and/or radiological outcome. The aim of this updated post-hoc analysis was to re-assess the results according to more precise techniques and take advantage of the 2 x 2 factorial design. Methods: A total of 407 overweight( BMI > or egal 27kg/m2) women of 50–60 years of age with no diagnosis of knee OA were randomized to: (1) noDEP + placebo(Control, N = 102), (2) DEP + placebo (DEP, N = 101), (3) glucosamine sulfate + no DEP (GS, N = 102), and (4) DEP + glucosamine sulfate (DEP + GS, N = 102) and followed for 2.5 years, with standardized postero-anterior, semiflexed (MTP) view knee radiographs at baseline and end of the study. DEP consisted of a tailored low fat and/or low caloric diet and easy to implement physical activities. Glucosamine was given as oral crystalline glucosamine sulfate 1500 mg once daily ,double-blinded vs. placebo. Incident knee OA was defined as radiographic progression of >1mm minimum joint space narrowing (mJSN)in the medial tibiofemoral compartment, as previously assessed by the visual (manual) technique and by a new semi-automated method. Logistic regression analysis was used t ocalculate the odds ratio for the effect of the interventions. Results: After 2.5 years, 11.8% of control subjects developed knee OA. This incidence was decreased with glucosamine sulfate, either alone or in combination with the DEP, but not by the DEP alone. Since there was no statistical interaction between treatments, the 2x2 factorial design allowed analysis of patients receiving glucosamine sulfate (N = 204) vs. those not receiving it (N= 203), similarly for those on the DEP (N = 203) or not (N = 204). Glucosamine sulfate significantly decreased the risk of developing knee OA: odds ratio (OR) = 0.41(95% CI: 0.20–0.85, P = 0.02) by the manual JSN assessment method and OR = 0.42 (95% CI:0.20–0.92, P =0.03) by the semi-automated technique. Conversely, there was no decrease in risk with the DEP. Conclusions: Glucosamine sulfate decreased the risk of developing radiographic knee OA over 2.5 years in overweight, middle-aged women at risk, as determined by medial mJSN progression. Conversely a tailored diet and exercise program exerted no preventive effect, possibly because of the lower than expected effect on weigh tloss. [less ▲]

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See detailA phase IV, two-armed, randomized, cross-over study comparing compliance with once-a-month administration of vitamin D3 to compliance with daily administration of a fixed-dose combination of vitamin D3 and calcium during two 6-month periods
Bruyère, Olivier ULiege; DEROISY, Rita ULiege; Dardenne, Nadia ULiege et al

in Osteoporosis International (2015), 26(12), 2863-8

Summary In a randomized, cross-over study, once monthly administration of vitamin D3 was preferred over a once daily administration of a fixed-dose combination of vitamin D3 and calcium, with a better ... [more ▼]

Summary In a randomized, cross-over study, once monthly administration of vitamin D3 was preferred over a once daily administration of a fixed-dose combination of vitamin D3 and calcium, with a better compliance but without any significant difference in the increase in vitamin D levels. Introduction The aim of the present study was to compare a once-monthly administration of vitamin D3 to a daily administration of a fixed-dose combination of vitamin D3 and calcium during two treatment periods of 6 months. Methods One hundred volunteers aged 50 years old or older were randomized to receive either one drinkable ampoule containing 25,000 IU vitamin D3 (D-Cure®, SMB) once monthly (group VD) or one chewable tablet containing 1000 mg calcium carbonate+800 IU vitamin D3 (Steovit Forte®, Takeda) once daily (group VDCa) during 6 months. After the first 6 months of treatment, the groups were reversed according to the randomized cross-over design. Treatment compliance (i.e. the primary outcome), preference, acceptability and vitamin D levels and adverse events were all collected. Results For the two periods, the patients had a significantly higher compliance in the VD group than in the VDCa group (p<0.0001). During the study, 50 (56.8 %) patients preferred the VD treatment, 16 (18.2 %) patients preferred the VDCa, and for 22 (25.0 %) patients, neither treatment was preferred. At the end of the first 6 months of treatment, the mean (SD) increase of 25(OH)D was 6.57 ng/mL (8.19) in the VD group and 3.88 ng/mL (10.0) in the VDCa group (p=0.16 between groups). Conclusion In this study, a once-monthly administration of vitamin D3 was preferred over a once-daily administration of a fixed-dose combination of vitamin D3 and calcium, with a better compliance but without any significant difference in the increase in vitamin D levels. [less ▲]

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See detailReproducibility of joint space width assessment when external calibration on the radiograph is missing
DEROISY, Rita ULiege; Reginster, Jean-Yves ULiege; Bruyère, Olivier ULiege

in Osteoporosis International (2013, April), 24(Suppl.1), 379

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See detailSevere prevalent vertebral fractures predict subsequent vertebral and nonvertebral fractures: a 3-year prospective study
Bruyère, Olivier ULiege; Roux, Christian; Nicolet, Delphine ULiege et al

in Annals of the Rheumatic Diseases (2012, June), 71(Suppl.3), 588

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See detailSeverity of incident vertebral fracture and future fracture risk: a 3-year prospective study
Bruyère, Olivier ULiege; Roux, Christian; Nicolet, Delphine ULiege et al

in Annals of the Rheumatic Diseases (2012, June), 71(Suppl.3), 716

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See detailSeverity of incident vertebral fracture and future fracture risk: a 3-year prospective study
Bruyère, Olivier ULiege; Roux, Christian; Nicolet, Delphine ULiege et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 60-61

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See detailSevere prevalent vertebral fractures predict subsequent vertebral and nonvertebral fractures: a 3-year prospective study
Bruyère, Olivier ULiege; Roux, Christian; Nicolet, Delphine ULiege et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 361-362

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See detailAssessment of joint space narrowing in knee osteoarthritis has good long-term intercentre reproducibility when read in pairs with a semi-automated device
Gensburger, Deborah; DEROISY, Rita ULiege; Arlot, Monique et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 247-248

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See detailLong-term (3 years) reproducibility for the radiological assessment of knee osteoarthritis
DEROISY, Rita ULiege; Bruyère, Olivier ULiege; Gensburger, Deborah et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 219-220

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See detailStable precision over time when assessing the cartilage loss on knee osteoarthritis radiograph
DEROISY, Rita ULiege; Bruyère, Olivier ULiege; Reginster, Jean-Yves ULiege

in Osteoporosis International (2011, March), 22(Suppl.1), 42-43246

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See detailLong term agreement between two different centres regarding joint space narrowing measurement in knee osteoarthritis
Deroisy, Rita ULiege; Roux, J. P.; Bruyère, Olivier ULiege et al

in Osteoporosis International (2010, May), 21(Suppl.1), 233-234

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See detailStrontium ranelate: new data on fracture prevention and mechanisms of action.
Reginster, Jean-Yves ULiege; Deroisy, Rita ULiege; Neuprez, Audrey et al

in Current Osteoporosis Reports (2009), 7(3), 96-102

Osteoporosis treatments need to combine an unequivocally demonstrated reduction of fractures, at various skeletal sites, long-term safety, and a user-friendly profile that optimizes therapeutic adherence ... [more ▼]

Osteoporosis treatments need to combine an unequivocally demonstrated reduction of fractures, at various skeletal sites, long-term safety, and a user-friendly profile that optimizes therapeutic adherence. Strontium ranelate is the first compound to simultaneously decrease bone resorption and stimulate bone formation. Its anti-fracture efficacy at various skeletal sites has been established for as long as 5 years through studies of the highest methodological standards. Increases in bone mineral density observed after 1 year of treatment are predictive of the long-term fracture efficacy, suggesting for the first time in osteoporosis that bone densitometry can be used as a monitoring tool. Due to a positive risk/benefit ratio, strontium ranelate is now considered as a first-line treatment in the management of osteoporosis. [less ▲]

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See detailBone mineral density and health related quality of life: a 3-year follow-up study of osteoportic postmenopaul women
Bruyère, Olivier ULiege; De Cock, Caroline; Deroisy, Rita ULiege et al

in The Open Geritric Medicine Journal (2009), 2

Objective: The objective of this study was to evaluate the relationship between change in bone mineral density (BMD) and change in health related quality of life (HRQoL) over a 3-year eriod, in patients ... [more ▼]

Objective: The objective of this study was to evaluate the relationship between change in bone mineral density (BMD) and change in health related quality of life (HRQoL) over a 3-year eriod, in patients without incident of osteoporotic fracture. Materials and Methods: Prior to the present study, two randomized controlled trials had been carried out to assess the efficacy of a new anti-osteoporotic drug. From the placebo group of those two trials, we selected for the present study 1838 osteoporotic postmenopausal women aged over 50 years, and followed their progress for a period of 3 years. BMD was measured at the lumbar spine and the proximal femur by dual-energy X-ray absorptiometry. Each patient received calcium and vitamin D supplements. HRQoL was assessed using 2 questionnaires: the generic tool Short Form 36 items (SF-36; including mental and physical components) and the specific Quality of Life Questionnaire in Osteoporosis (QUALIOST). Result: At baseline, after adjustment for body mass index (BMI), age, number of vertebral fractures and number of peripheral fractures, multivariate regression analysis showed a significant association between the lumbar BMD and the mental component of the SF-36 (p<0.001). However, the relationship was not significant with the global score of the QUALIOST (p=0.098) and the physical component of the SF-36 (p=0.051). Multivariate regressions did not show a significant relationship between HRQoL and proximal femur BMD at baseline. After 3 years of follow-up, multivariate regression analysis showed no significant association between change in lumbar BMD and the main HRQoL items (global score of the QUALIOST, physical and mental components of the SF-36; p between 0.437 and 0.942). No significant relationships were found between change in femoral BMD and change in the global score of the QUALIOST (p=0.088) or change in the mental component of the SF-36 (p=0.222). However, a significant positive association (p=0.031) appeared between change in the physical component of the SF-36 and femoral BMD change. Conclusion: In osteoporotic postmenopausal women receiving calcium and vitamin D, few relationships were found between BMD and HRQoL. However, these results were not strong enough to indicate a real clinically interesting relationship between HRQoL and BMD. Other studies would need to be performed to verify these results. [less ▲]

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See detailAssociation between lumbar disc degeneration and biochemical markers of bone and cartilage remodelling
Bruyère, Olivier ULiege; Collette, Julien ULiege; Christiansen, F. et al

in Annals of the Rheumatic Diseases (2008, June), 67(Suppl.II), 231

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See detailAssociation between spinal osteoarthritis and biochemical markers of bone and cartilage remodelling
Bruyère, Olivier ULiege; Collette, Julien ULiege; Christiansen, C. et al

in Osteoporosis International (2008, April), 19(Suppl.1), 200

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See detailRole of Biochemical Markers of Bone Turnover as Prognostic Indicator of Successful Osteoporosis Therapy
Reginster, Jean-Yves ULiege; Collette, Julien ULiege; Neuprez, Audrey et al

in BONE (2008), 42

Most of the currently available anti-osteoporosis medications promptly and significantly influence the rate of bone turnover. Biochemical markers of bone turnover now provide a high sensitivity to change ... [more ▼]

Most of the currently available anti-osteoporosis medications promptly and significantly influence the rate of bone turnover. Biochemical markers of bone turnover now provide a high sensitivity to change, allowing the detection of these bone turnover changes within a couple of weeks. Since the anti-fracture efficacy of inhibitors of bone resorption or stimulators of bone formation appears to be largely independent of baseline bone turnover, biochemical markers do not appear to play a significant role in the selection of one particular drug, for an individual patient. However, there are consistent data showing that short-term changes in biochemical markers of bone turnover may be significant predictors of future changes in bone mineral density or fracture reduction, hence suggesting that bone turnover markers play a significant role in the monitoring of anti-osteoporosis therapy. [less ▲]

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