References of "DELGAUDINE, Marie"
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See detailFrom reporting incidents in a radiation therapy department to enterprise risk management (ERM) based on the European Foundation for Quality Management philosophy (EFQM)
COUCKE, Philippe ULg; BOGA, Deniz ULg; LENAERTS, Eric ULg et al

in International Journal of Healthcare Technology & Management (2014), 7(2), 127-131

The radiation therapy department (RTD) initiated in 2009 a policy of open and transparent reporting of events not harming (near incidents) and potentially harming patients (incidents and accidents). This ... [more ▼]

The radiation therapy department (RTD) initiated in 2009 a policy of open and transparent reporting of events not harming (near incidents) and potentially harming patients (incidents and accidents). This approach was immediately followed by the leader’s decision to engage towards the European Foundation for Quality Management (EFQM) excellence model. The EFQM approach structured the journey of the RTD to enterprise risk management. We intend to demonstrate in the five main fields of the EFQM approach (leadership, policy and strategy, people/personnel, partnership and resources, processes), how the journey to continuous improvement in quality and safety did evolve and was accelerated in RTD. The assessment made by external evaluators evolved from a minimum of 90 points (basic requirement for level 1 in 2009) to a at least 180 points (basic requirement for level 2 in 2011), to reach 400 points in 2013 (270 required for level 3 and 450 required for level 4). [less ▲]

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See detailÉLABORATION D’UN PLAN DE FORMATION CONTINUE À PARTIR DE L’APPROCHE PROCESSUS DANS UN SERVICE DE RADIOTHÉRAPIE
LENAERTS, Eric ULg; DELGAUDINE, Marie ULg; COUCKE, Philippe ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 104-110

Pour garantir l’intégration des évolutions technolo - giques régulières et des changements organisationnels qui en découlent, le Service de Radiothérapie du CHU de Liège, s’est engagé depuis 2007 dans la ... [more ▼]

Pour garantir l’intégration des évolutions technolo - giques régulières et des changements organisationnels qui en découlent, le Service de Radiothérapie du CHU de Liège, s’est engagé depuis 2007 dans la définition et la coordination d’une politique de qualité des soins et de sécurité du patient cohérente et globale. L’équipe dirigeante du service considère la gestion des compétences comme un impératif indispensable afin de pouvoir intégrer rapidement l’utilisation des nouvelles tech - nologies de traitement tout en fournissant de manière continue des soins de haute qualité aux patients. L’approche « proces - sus » consiste à décrire, de façon méthodique, une organisation en processus en vue de contribuer à la satisfaction du patient. Cette approche appliquée dans le service de radiothérapie a permis une meilleure visibilité du fonctionnement du service ainsi qu’une meilleure maîtrise des relations entre les collabo - rateurs et avec les patients. Elle permet de maîtriser la valeur ajoutée de chaque processus, d’identifier les points de risques et d’en anticiper les dérives. Plus précisément, l’approche processus a conduit à préciser les compétences requises pour garantir une haute qualité des soins et à concevoir un plan de formation continue spécifique aux besoins d’un service de radiothérapie. Ce plan a été reconnu au travers de la création d’un certificat universitaire spécifique [less ▲]

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See detailOperational Risk Management (ORM): the aviation safety model can be transposed into the medical sector
COUCKE, Philippe ULg; DELGAUDINE, Marie ULg; BOGA, Deniz ULg et al

in Belgian Journal of Medical Oncology [=BJMO] (2013), 7(5), 137-141

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See detailPractical application of Reason's model in a department of radiotherapy
DELGAUDINE, Marie ULg; LENAERTS, Eric ULg; RENARD, A et al

Conference (2012)

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See detailMyocardial infarct size quantification in mice by SPECT using a novel algorithm independent of a normal perfusion database
Roelants, Véronique; DELGAUDINE, Marie ULg; Walrand, Stephan et al

in European Journal of Nuclear Medicine and Molecular Imaging Research (2012), 2

Background: There is a growing interest in developing non-invasive imaging techniques permitting infarct size (IS) measurements in mice. The aim of this study was to validate the high-resolution rodent ... [more ▼]

Background: There is a growing interest in developing non-invasive imaging techniques permitting infarct size (IS) measurements in mice. The aim of this study was to validate the high-resolution rodent Linoview single photon emission computed tomography (SPECT) system for non-invasive measurements of IS in mice by using a novel algorithm independent of a normal database, in comparison with histology. Methods: Eleven mice underwent a left coronary artery ligature. Seven days later, animals were imaged on the SPECT 2h30 after injection of 173 ± 27 MBq of Tc-99m-sestamibi. Mice were subsequently killed, and their hearts were excised for IS determination with triphenyltetrazolium chloride (TTC) staining. SPECT images were reconstructed using the expectation maximization maximum likelihood algorithm, and the IS was calculated using a novel algorithm applied on the 20-segment polar map provided by the commercially available QPS software (Cedars-Sinai Medical Center, CA, USA). This original method is attractive by the fact that it does not require the implementation of a normal perfusion database. Results: Reconstructed images allowed a clear delineation of the left ventricles borders in all mice. No significant difference was found between mean IS determined by SPECT and by TTC staining [37.9 ± 17.5% vs 35.6 ± 17.2%, respectively (P = 0.10)]. Linear regression analysis showed an excellent correlation between IS measured on the SPECT images and IS obtained with TTC staining (y = 0.95x + 0.03 (r = 0.97; P < 0.0001)), without bias, as demonstrated by the Bland-Altman plot. Conclusion: Our results demonstrate the accuracy of the method for the measurement of myocardial IS in mice with the Linoview SPECT system. [less ▲]

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See detaily a-t-il une place pour la radiothérapie en fin de vie ?
BARTHELEMY, Nicole ULg; JANSEN, Nicolas ULg; GENNIGENS, Christine ULg et al

in Revue Médicale de Liège (2012), 67(3), 128132

Près de 50 % des patients atteints d’un cancer bénéficient, à un moment de leur trajet de soins, d’une irradiation. Celle-ci peut être administrée avec une intention curative ou palliative, en fonction de ... [more ▼]

Près de 50 % des patients atteints d’un cancer bénéficient, à un moment de leur trajet de soins, d’une irradiation. Celle-ci peut être administrée avec une intention curative ou palliative, en fonction de l’extension de la maladie, de l’état général du patient et de sa volonté. Le but d’une irradiation palliative, sera de contrôler localement la tumeur ou la métastase et, donc, de ralentir l’évolution du cancer. La radiothérapie peut également être utile pour supprimer un symptôme et, ainsi, être un des traitements de confort en fin de vie. La dose totale, la dose par fraction ainsi que la technique d’irradiation sont adaptées à l’intention du traitement. Cet article passe en revue les principales indications d’irradiation en fin de vie. [less ▲]

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See detailA method for evaluating weaknesses and critical steps in the Radiation Treatment Process through Precursor Events reporting
LENAERTS, Eric ULg; DELGAUDINE, Marie ULg; COUCKE, Philippe ULg

Poster (2011, September)

objectives: to establish a method based on the reporting of precursor events to detect and to assess weak steps in the Radiation Treatment process. These steps are categorized according to Work domains ... [more ▼]

objectives: to establish a method based on the reporting of precursor events to detect and to assess weak steps in the Radiation Treatment process. These steps are categorized according to Work domains, functional Basic Responsibilities and levels of Severity of precursor events [less ▲]

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See detailExperience feed back committee (EFBC) in radiotherapy
DELGAUDINE, Marie ULg; JANSEN, Nicolas ULg; COUCKE, Philippe ULg

Poster (2010, September)

Radiotherapy is a powerful continuously evolving effective treatment tool. Our aim is to offer the best treatments and assure security for patients and personnel. A proactive quality approach copied from ... [more ▼]

Radiotherapy is a powerful continuously evolving effective treatment tool. Our aim is to offer the best treatments and assure security for patients and personnel. A proactive quality approach copied from the one implemented in the air transport industry has been established in our department. An Experience feed back committee (EFBC) has been set up to identify, record and analyze systematically all reported precursor events. Our final objective is to test and strengthen the security of the organization and the quality of care for patients. [less ▲]

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See detailSystematic chromosomal aberrations found in murine bone marrow-derived mesenchymal stem cells.
Josse, Claire ULg; Schoemans, R.; Niessen, Neville-Andrew ULg et al

in Stem Cells & Development (2010), 19(8), 1167-1173

Mesenchymal stem cells (MSCs) are studied as a cellular source for the treatment of various diseases. In this work, we isolated and cultivated murine bone marrow-derived MSCs. After a first observation of ... [more ▼]

Mesenchymal stem cells (MSCs) are studied as a cellular source for the treatment of various diseases. In this work, we isolated and cultivated murine bone marrow-derived MSCs. After a first observation of a solid tumour in a mouse injected with these cells, we systematically explored their chromosomal stability. We observed in all the cytogenetically analysed cases gross chromosomal alterations every time the MSCs went through the senescence crisis while the lymphocytes from the same animals showed a normal chromosome count. This observation was confirmed in different mouse strains, with different culture protocols, and even in short-term cultures after an hematopoietic cell negative immunodepletion performed in order to accelerate the isolation procedure. Therefore, we conclude that murine MSCs display high chromosomal instability, can generate tumours, and that care must be taken before using them for the evaluation of MSC therapeutic potential. [less ▲]

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See detailExperience feed back committee and evaluation of weaknesses and critical
DELGAUDINE, Marie ULg; LENAERTS, Eric ULg; COUCKE, Philippe ULg

Poster (2010)

Radiotherapy is a powerful continuously evolving effective treatment tool. Our aim is to offer the best treatments and assure security for patients and personnel. A proactive quality approach copied from ... [more ▼]

Radiotherapy is a powerful continuously evolving effective treatment tool. Our aim is to offer the best treatments and assure security for patients and personnel. A proactive quality approach copied from the one implemented in the air transport industry has been established in our department. An Experience Feed Back Committee (EFBC) has been set up to identify, record and analyze systematically all reported precursor events. Our final objective is to test and strengthen the security of the organization and the quality of care for patients. [less ▲]

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See detailThérapie cellulaire de réparation tissulaire cardiaque par cellules souches hématopoïétiques et mésenchymateuses.
DELGAUDINE, Marie ULg

Doctoral thesis (2010)

Les scientifiques définissent les cellules souches (CS) en se basant sur 3 critères (Fig.1): (1) les CS sont douées de capacités d’auto-renouvellement qui leur permettent de maintenir leur « pool » stable ... [more ▼]

Les scientifiques définissent les cellules souches (CS) en se basant sur 3 critères (Fig.1): (1) les CS sont douées de capacités d’auto-renouvellement qui leur permettent de maintenir leur « pool » stable ; (2) une CS peut se différencier en plusieurs types de cellules fonctionnelles matures. Par exemple, les cellules souches hématopoïétiques (CSH) sont à l’origine des cellules sanguines ; les cellules souches neurales (CSN) donnent naissance aux neurones, astrocytes et oligodendrocytes ; les cellules souches mésenchymateuses (CSM) peuvent se différencier en fibroblastes, ostéoblastes, chondroblastes et adipocytes ; (3) les cellules souches peuvent repeupler un tissu lésé pour en restaurer la fonction, comme notamment, après une irradiation. [less ▲]

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See detailSpontaneous and granulocyte–colony-stimulating factor-enhanced marrow response and progenitor cell mobilization in mice after myocardial infarction.
Delgaudine, Marie ULg; Gothot, André ULg; Beguin, Yves ULg

in Cytotherapy (2010), 12(7), 909-18

BACKGROUND AIMS: Hematopoietic (HPC), mesenchymal (MPC) and/or endothelial (EPC) progenitor cells are being studied to repair the myocardium after acute or chronic ischemia. We examined marrow response to ... [more ▼]

BACKGROUND AIMS: Hematopoietic (HPC), mesenchymal (MPC) and/or endothelial (EPC) progenitor cells are being studied to repair the myocardium after acute or chronic ischemia. We examined marrow response to myocardial infarction (MI) and the ability of granulocyte-colony-stimulating factor (G-CSF) to enhance mobilization of HPC, MPC and EPC in peripheral blood (PB) and bone marrow (BM) of MI mice. METHODS: We induced MI in C57Bl/6 mice, while sham-operated (SO) animals were similarly operated on but without coronary artery ligation. Animals were treated with either saline or G-CSF, from day -5 to day +5 after MI or from day 0 to day +5. Progenitor cell numbers in PB and BM were evaluated by fluorescence-activated cell sorting (FACS) analysis and cell culture. RESULTS: White blood cells (WBC) decreased in BM and increased in PB after MI; G-CSF amplified this effect in BM but not in PB. HPC numbers decreased in BM after MI, while HPC and granulocyte-macrophage colony-forming units (GM-CFU) increased in PB only after G-CSF treatment, and more prominently so in MI than in SO mice. MPC and fibroblast-colony-forming units (F-CFU) as well as EPC were mobilized into the PB after MI and further after G-CSF treatment. Plasma troponin T concentrations decreased after G-CSF treatment. CONCLUSIONS: BM is globally affected by acute MI, but not simple body injury, with intense mobilization of marrow MPC and EPC into the PB but inhibition of HPC. Progenitor cell entry into the PB may be paralleled by depletion of their BM pools. G-CSF is required for HPC mobilization and enhances MPC and EPC entry into the PB. [less ▲]

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