Strontium ranelate improves osteoarthritis symptoms compared to placebo in patients with knee OA: The SEKOIA study

in Osteoporosis International (2013, April), 24(Suppl.1), 49-51

Five years of denosumab exposure in women with postmenopausal osteoporosis: Results from the first two years of the FREEDOM extension.

in Journal of Bone and Mineral Research (2012), 27(3), 694-701

The 3-year FREEDOM trial assessed the efficacy and safety of 60 mg denosumab every 6 months for treatment of postmenopausal women with osteoporosis. Participants who completed FREEDOM were eligible to ... [more ▼]

The 3-year FREEDOM trial assessed the efficacy and safety of 60 mg denosumab every 6 months for treatment of postmenopausal women with osteoporosis. Participants who completed FREEDOM were eligible to enter an extension to continue the evaluation of denosumab efficacy and safety for up to 10 years. For the extension results presented here, women from the FREEDOM denosumab group had 2 more years of denosumab treatment (long-term group) and those from the FREEDOM placebo group had 2 years of denosumab exposure (cross-over group). We report results for bone turnover markers (BTMs), bone mineral density (BMD), fractures rates, and safety. A total of 4550 women enrolled in the extension (2343 long-term; 2207 cross-over). Reductions in BTMs were maintained (long-term group) or occurred rapidly (cross-over group) following denosumab administration. In the long-term group, lumbar spine and total hip BMD increased further, resulting in 5-year gains of 13.7% and 7.0%, respectively. In the cross-over group, BMD increased at the lumbar spine (7.7%) and total hip (4.0%) during the 2-year denosumab treatment. Yearly fracture incidences for both groups were below rates observed in the FREEDOM placebo group and below rates projected for a "virtual untreated twin" cohort. Adverse events did not increase with long-term denosumab administration. Two adverse events in the cross-over group were adjudicated as consistent with osteonecrosis of the jaw (ONJ). Five-year denosumab treatment of women with postmenopausal osteoporosis maintained BTM reduction and increased BMD, and was associated with low fracture rates and a favorable risk/benefit profile. (c) 2011 American Society for Bone and Mineral Research. [less ▲]

Treatment of postmenopausal women with osteoporosis for six years with denosumab : three-year results from the freedom extension

in Annals of the Rheumatic Diseases (2012), 71(3), 588

Denosumab therapy in postmenopausal women with osteoporosis : results from the first two years of the freedom trial extension

in Endocrine Reviews (2011), 32

Safety observations from denosumab long-term extension and cross-over studies in postmenopausal women with osteoporosis

in Journal of Bone and Mineral Research (2011), 26(S1), 22-23

Treatment of postmenopausal women with osteoporosis for 5 years with denosumab : two-year results from the FREEDOM trial extension

in Annals of the Rheumatic Diseases (2011), 70(S3), 166-167

Long-term denosuamab treatment in postmenopausal women with osteoporosis : results from the first two years of the FREEDOM trial extension

in Osteoporosis International (2011), 22(S4), 527-528

Efficacy of monthly oral ibandronate is maintained over 5 years: The MOBILE LTE study.

in Osteoporosis International (2009, March), 20(Suppl.1), 15

Intermittent intravenous (i.v.) ibandronate injections are more effective than an established daily oral regimen: DIVA 2-year results

in Osteoporosis International (2007, March), 18(Suppl.1), 127