References of "Courtoy, R"
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See detailCell Surface Receptors in Lymphoid Cells: From Cytochemistry to Molecular Biology and from a Phenotype to a Function
Boniver, Jacques ULg; Courtoy, R.; Schaaf-Lafontaine, Nicole ULg et al

in Progress in Histochemistry and Cytochemistry (1992), 26(1-4), 169-81

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See detailOntogeny of T-Cell Surface Molecules and Receptors in the Thymus
Defresne, Marie-Paule ULg; Humblet, Chantal ULg; Deman, J. et al

in Progress in Histochemistry and Cytochemistry (1992), 26(1-4), 194-200

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See detailUltrastructural demonstration of histamine in human enterochromaffin like cell granules.
Delwaide, Jean ULg; Vivario, M.; Belaiche, Jacques ULg et al

in Gut (1991), 32(7), 834

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See detailCellular Events in Radiation-Induced Lymphomagenesis
Boniver, Jacques ULg; Humblet, Chantal ULg; Rongy, A. M. et al

in International Journal of Radiation Biology (1990), 57(4), 693-8

Fractionated whole-body irradiation induces thymic lymphomas in most of treated C57Bl/Ka mice. The cellular events occurring during the latency period consist of the emergence of preleukaemic cells and of ... [more ▼]

Fractionated whole-body irradiation induces thymic lymphomas in most of treated C57Bl/Ka mice. The cellular events occurring during the latency period consist of the emergence of preleukaemic cells and of marked alterations to the T-cell lineage and the microenvironment within the thymus. The proportions of the various thymocyte subsets are modified, suggesting a blockage in the normal differentiation process. Thymic epithelial cells are functionally modified, leading to decreased interactions with immature thymocytes. Interestingly, bone marrow grafting early after irradiation, which inhibits the development of lymphomas, induces the disappearance of preleukaemic cells from the thymus, whereas thymocyte subpopulations and thymic epithelium are restored. Interferon gamma and tumor necrosis factor alpha also prevent the onset of lymphomas. Studies on the effect of bone marrow transplantation and cytokine inoculation in split-dose irradiated mice should allow characterization of the factors that modulate the progression of preleukaemic cells towards the neoplastic state. [less ▲]

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See detailCellular Aspects of the Pathogenesis of Radiation--Induced Thymic Lymphomas in C57 Bl Mice (Review)
Boniver, Jacques ULg; Humblet, Chantal ULg; Rongy, A. M. et al

in In Vivo (Athens, Greece) (1990), 4(1, Jan-Feb), 41-3

Radiation-induced thymic lymphomas in C57Bl/Ka mice are interesting models for studying the successive steps of carcinogenesis. Irradiation initiates "preleukemic" cells, which are promoted to become ... [more ▼]

Radiation-induced thymic lymphomas in C57Bl/Ka mice are interesting models for studying the successive steps of carcinogenesis. Irradiation initiates "preleukemic" cells, which are promoted to become neoplastic. Studies in mice in which lymphoma development is inhibited by a bone marrow transplantation after irradiation suggest that radiation--induced alterations to the T cell lineage, and particularly to thymic microenvironment, are critical for the promotion of preleukemic cells. It is proposed that the lack of physiological differentiation signals within the thymus, as a result of irradiation, allows these cells to escape the normal controls of thymocyte production and pushes them towards neoplastic transformation. A disturbance in the production of cytokines may be involved, since exogenous cytokines, such as Interferon gamma or Tumor Necrosis Factor a, can inhibit radiation-induced lymphomagenesis, reproducing the effects of bone marrow transplantation. The model is thus suitable for studying the mechanisms of carcinogenesis and designing biological manipulation devoted to cancer prevention in individuals who have been exposed to oncogenic agents. [less ▲]

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See detailRadiation Leukemia Virus: A Marker for the Study of Intrathymic T Cell Differentiation
Boniver, Jacques ULg; Delvenne, Catherine ULg; Janowski, M. et al

in Thymus (1989), 14(1-3), 109-13

Radiation Leukemia Virus (RadLV) is a retrovirus, which displays a highly specific thymotropism; after inoculation into young C57 BL/Ka mice, active virus replication is observed only in thymocytes and ... [more ▼]

Radiation Leukemia Virus (RadLV) is a retrovirus, which displays a highly specific thymotropism; after inoculation into young C57 BL/Ka mice, active virus replication is observed only in thymocytes and thymic lymphomas develop in most treated mice. The specific interaction between RadLV and the thymus resides in the particular susceptibility to infection of the most immature cells involved in the intrathymic lymphoid differentiation pathway and of non lymphoid thymic stromal cells. Recent data obtained from 'in situ' hybridization studies for detection of viral transcripts yield more detailed informations on these intriguing interactions. [less ▲]

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See detailMammosomatotropes in Human Pituitary Adenomas as Revealed by Electron Microscopic Double Gold Immunostaining Method
Beckers, Albert ULg; Courtoy, R.; Stevenaert, Achille ULg et al

in Acta Endocrinologica (1988), 118(4), 503-12

Hormone production was studied in situ by immunocytochemical methods in 20 pituitary adenomas. Special attention was given to 13 adenomas removed from acromegalic patients. Out of them, 6 had mild to ... [more ▼]

Hormone production was studied in situ by immunocytochemical methods in 20 pituitary adenomas. Special attention was given to 13 adenomas removed from acromegalic patients. Out of them, 6 had mild to moderate hyperprolactinemia. Immunohistochemistry revealed PRL-containing cells without any close relationship with high PRL serum level in 6 patients. Double immunogold staining revealed mammosomatotrope cells characterized by simultaneous presence of GH and PRL in the same granules in 2 patients. Since mammosomatotropes have never been demonstrated in the normal pituitary, our results probably signify gene dysregulation in pituitary cells of those acromegalic patients. [less ▲]

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See detailImmunocytochemical demontration of hormones in cell granules of several human pituitary adenomas
Beckers, Albert ULg; Courtoy, R.; Stevenaert, Achille ULg et al

in Histochemical Journal (The) (1986), 18(1), 55

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See detailImmunocytochemical demonstration of hormones in cells granules of several human pituitary adenomas
Beckers, Albert ULg; Stevenaert, Achille ULg; Courtoy, R. et al

in Histochemical Journal (The) (1986)

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See detailLocalisation ultrastructurale d'hormones hypophysaires par reaction immunocytochimique sur coupes fines d'adenomes.
Beckers, Albert ULg; Courtoy, R.; Reznik, Michel ULg et al

in Comptes Rendus des Séances de la Société de Biologie et de ses Filiales (1985), 179(3), 397-402

Human pituitary adenomas were fixed in glutaraldehyde and embedded in epon. Ultrathin sections were incubated either with anti-hGH, anti-hPRL or anti-hLH. They were incubated with second step goat anti ... [more ▼]

Human pituitary adenomas were fixed in glutaraldehyde and embedded in epon. Ultrathin sections were incubated either with anti-hGH, anti-hPRL or anti-hLH. They were incubated with second step goat anti-rabbit immunoglobulins linked to gold particles. Two PRL secreting adenomas, one GH and PRL secreting adenoma, one ACTH secreting adenoma and two non secreting adenomas were studied. The specificity and the limits of the method were discussed in relation with the results obtained in light microscopy with the PAP method. [less ▲]

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See detailImmunogold staining of pituitary hormones in human adenoma biopsies
courtoy, r; Beckers, Albert ULg; Stevenaert, Achille ULg et al

in Biology of the Cell (1985)

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See detailUltrastructural immunocytochemical localization of hormones in human pituitary adenomas
Beckers, Albert ULg; Courtoy, R.; Stevenaert, Achille ULg et al

in Neuroendocrinology letters (1985)

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See detailImmunogold staining of pituitary hormones in human adenoma biopsies.
Beckers, Albert ULg; Courtoy, R.; Reznik, Michel ULg et al

in Biology of the Cell (1985)

Detailed reference viewed: 4 (0 ULg)