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See detailMultimodality imaging in restrictive cardiomyopathies: an EACVI expert consensus document: In collaboration with the 'Working Group on myocardial and pericardial diseases' of the European Society of Cardiology Endorsed by the Indian Academy of Echocardiography
Habib, G; Bucciarelli-Ducci, C; Caforio, ALP et al

in European Heart Journal - Cardiovascular Imaging (2017)

Restrictive cardiomyopathies (RCMs) are a diverse group of myocardial diseases with a wide range of aetiologies, including familial, genetic and acquired diseases and ranging from very rare to relatively ... [more ▼]

Restrictive cardiomyopathies (RCMs) are a diverse group of myocardial diseases with a wide range of aetiologies, including familial, genetic and acquired diseases and ranging from very rare to relatively frequent cardiac disorders. In all these diseases, imaging techniques play a central role. Advanced imaging techniques provide important novel data on the diagnostic and prognostic assessment of RCMs. This EACVI consensus document provides comprehensive information for the appropriateness of all non-invasive imaging techniques for the diagnosis, prognostic evaluation, and management of patients with RCM. [less ▲]

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See detailRational and design of EuroCRT: an international observational study on multi-modality imaging and cardiac resynchronization therapy
Donal, E; Delgado, V; Magne, J et al

in European Heart Journal - Cardiovascular Imaging (2017)

Aims: Assessment of left ventricular (LV) volumes and ejection fraction (LVEF) with cardiac imaging is important in the selection of patients for cardiac resynchronization therapy (CRT). Several ... [more ▼]

Aims: Assessment of left ventricular (LV) volumes and ejection fraction (LVEF) with cardiac imaging is important in the selection of patients for cardiac resynchronization therapy (CRT). Several observational studies have explored the role of imaging-derived LV dyssynchrony parameters to predict the response to CRT, but have yielded inconsistent results, precluding the inclusion of imaging-derived LV dyssynchrony parameters in current guidelines for selection of patients for CRT. METHODS: The EuroCRT is a large European multicentre prospective observational study led by the European Association of Cardiovascular Imaging. We aim to explore if combing the value of cardiac magnetic resonance (CMR) and echocardiography could be beneficial for selecting heart failure patients for CRT in terms of improvement in long-term survival, clinical symptoms, LV function, and volumes. Speckle tracking echocardiography will be used to assess LV dyssynchrony and wasted cardiac work whereas myocardial scar will be assessed with late gadolinium contrast enhanced CMR. All data will be measured in core laboratories. The study will be conducted in European centres with known expertise in both CRT and multimodality cardiac imaging. [less ▲]

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See detailEchocardiographic reference ranges for normal left ventricular 2D strain: results from the EACVI NORRE study
Sugimoto, T; DULGHERU, Raluca Elena ULg; BERNARD, Anne-Catherine ULg et al

in European Heart Journal - Cardiovascular Imaging (2017)

Aims To obtain the normal ranges for 2D echocardiographic (2DE) measurements of left ventricular (LV) strain from a large group of healthy volunteers accounting for age and gender. Methods and results A ... [more ▼]

Aims To obtain the normal ranges for 2D echocardiographic (2DE) measurements of left ventricular (LV) strain from a large group of healthy volunteers accounting for age and gender. Methods and results A total of 549 (mean age: 45.6 ± 13.3 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. 2DE data sets have been analysed with a vendor-independent software package allowing homogeneous measurements irrespective of the echocardiographic equipment used to acquire the data sets. The lowest expected values of LV strains and twist calculated as ± 1.96 standard deviations from the mean were −16.7% in men and −17.8% in women for longitudinal strain, −22.3% and −23.6% for circumferential strain, 20.6% and 21.5% for radial strain, and 2.2 degrees and 1.9 degrees for twist, respectively. In multivariable analysis, longitudinal strain decreased with age whereas the opposite occurred with circumferential and radial strain. Male gender was associated with lower strain for longitudinal, circumferential, and radial strain. Inter-vendor differences were observed for circumferential and radial strain despite the use of vendor-independent software. Importantly, no intervendor differences were noted in longitudinal strain. Conclusion The NORRE study provides contemporary, applicable 2D echocardiographic reference ranges for LV longitudinal, radial, and circumferential strain. Our data highlight the importance of age- and gender-specific reference values for LV strain. [less ▲]

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See detail3D echocardiographic reference ranges for normal left ventricular volumes and strain: results from the EACVI NORRE study
BERNARD, Anne-Catherine ULg; Addetia, K; DULGHERU, Raluca Elena ULg et al

in European Heart Journal - Cardiovascular Imaging (2017)

Aim: To obtain the normal ranges for 3D echocardiography (3DE) measurement of left ventricular (LV) volumes, function, and strain from a large group of healthy volunteers. Methods and results: A total of ... [more ▼]

Aim: To obtain the normal ranges for 3D echocardiography (3DE) measurement of left ventricular (LV) volumes, function, and strain from a large group of healthy volunteers. Methods and results: A total of 440 (mean age: 45 ± 13 years) out of the 734 healthy subjects enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study had good-quality 3DE data sets that have been analysed with a vendor-independent software package allowing homogeneous measurements regardless of the echocardiographic machine used to acquire the data sets. Upper limits of LV end-diastolic and end-systolic volumes were larger in men (97 and 42 mL/m2) than in women (82 and 35 mL/m2; P < 0.0001). Conversely, lower limits of LV ejection fraction were higher in women than in men (51% vs. 50%; P < 0.01). Similarly, all strain components were higher in women than in men. Lower range was -18.6% in men and -19.5% in women for 3D longitudinal strain, -27.0% and -27.6% for 3D circumferential strain, -33.2% and -34.4% for 3D tangential strain and 38.8% and 40.7% for 3D radial strain, respectively. LV volumes decreased with age in both genders (P < 0.0001), whereas LV ejection fraction increased with age only in men. Among 3DE LV strain components, the only one, which did not change with age was longitudinal strain. Conclusion: The NORRE study provides applicable 3D echocardiographic reference ranges for LV function assessment. Our data highlight the importance of age- and gender-specific reference values for both LV volumes and strain. [less ▲]

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See detailClinical outcome in asymptomatic severe aortic stenosis: Insights from the new proposed aortic stenosis grading classification
Lancellotti, Patrizio ULg; Magne, Julien ULg; Donal, E. et al

in Journal of the American College of Cardiology (2012), 59(3), 235-243

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See detailOccurrence of cardiovascular calcifications in normal, aging rats.
Roosens, B; Bala, G; Droogmans, S et al

in Experimental Gerontology (2012), 47(8), 614-9

BACKGROUND: Cardiovascular calcification is an independent predictor of morbidity and mortality and increases with age. Animal models are frequently used to investigate the underlying pathophysiology ... [more ▼]

BACKGROUND: Cardiovascular calcification is an independent predictor of morbidity and mortality and increases with age. Animal models are frequently used to investigate the underlying pathophysiology. Only scarce data regarding the effect of aging on calcifications in these animal models are available. The aim of this study is to investigate the occurrence of cardiovascular calcifications in normal, aging rats. METHODS: A mixed inbred/outbred population of 44 male Lewis/Wistar rats was studied. Group 1 of three-month-old rats, group 2 twelve-month-old, group 3 twenty-four-month-old and group 4 thirty-month-old rats. Calibrated integrated backscatter (cIB) values and blood parameters (creatinine, parathyroid hormone (PTH)) were measured, followed by ex-vivo micro-CT and histology as reference methods. RESULTS: Cardiovascular calcifications developed with age, as demonstrated by significantly increasing cIB values of the aortic valve and myocardium. This was confirmed by a significant increase in the calcified volume on ex-vivo micro-CT and in the histological calcium score. There was also a significantly higher level of creatinine and PTH with age. CONCLUSIONS: As in humans, cardiovascular calcifications progressively increase with age in the normal rat. Therefore the aging rat model could be used for studying calcifying cardiovascular disease. cIB might have a value in future studies for the early detection of subclinical calcifications in humans. [less ▲]

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See detailEffects of eythropoietin administration on mitral regurgitation and left ventricular remodeling in heart failure patients.
Cosyns, B.; Velez-Roa, S.; Droogmans, S. et al

in International Journal of Cardiology (2010), 138(3), 306-307

The effects of erythropoietin administration on mitral regurgitation in patients with congestive heart failure have not yet been examined. After 2 months, erythropoietin treatment results in a significant ... [more ▼]

The effects of erythropoietin administration on mitral regurgitation in patients with congestive heart failure have not yet been examined. After 2 months, erythropoietin treatment results in a significant reduction in left ventricular volumes and mitral regurgitation severity and improves hemodynamics. [less ▲]

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See detailImpact of prosthesis-patient mismatch on mitral regurgitation after aortic valve replacement
Unger, P.; Magne, Julien ULg; Vanden Eynden, F. et al

in Heart (2010), 96(20), 1627-1632

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See detailMitral regurgitation in patients with aortic stenosis undergoing valve replacement.
Unger, P.; Dedobbeleer, C.; Van Camp, G. et al

in Heart (2009)

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See detailMyocardial contractile reserve during exercise predicts left ventricular reserve remodelling after cardiac resynchromization therapy
Lancellotti, Patrizio ULg; Senechal, Mario; Moonen, Marie ULg et al

in European Journal of Echocardiography (2009), 10(5), 663-8

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See detailQuantitative assessment of myocardial contractile reserve during exercise in patients with mitral valve prolapse
Lancellotti, Patrizio ULg; Cosyns, B.; Van Camp, G. et al

in Circulation (2006, October 31), 114(18, Suppl. S), 707-708

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See detailDeterminants of exercise-induced changes in e/ea in patients with chronic systolic left ventricular dysfunction
Lancellotti, Patrizio ULg; Cosyns, B.; Van Camp, G. et al

in European Heart Journal (2006, August), 27(Suppl. 1), 711

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See detailDoes treatment with erythropoietin improve left ventricular systolic performance and mitral regurgitation in patients with heart failure and chronic kidney disease?
Cosyns, B.; Lancellotti, Patrizio ULg; Velez-Roa, S. et al

in European Heart Journal (2006, August), 27(Suppl. 1), 339

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See detailCardiac resynchronisation therapy reduces the incidence of permanent atrial fibrillation in heart failure patients
Cosyns, B.; Lancellotti, Patrizio ULg; Hoffer, E. et al

in European Heart Journal (2006, August), 27(Suppl. 1), 332

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See detailGlobal and regional parameters of dyssynchrony in ischemic and nonischemic cardiomyopathy
Van de Veire, N.; De Sutter, J.; Van Camp, G. et al

in American Journal of Cardiology (2005), 95(3), 421-423

In this study, color tissue Doppler imaging was used to assess global and regional mechanical dyssynchrony in patients with ischemic cardiomyopathy and those with idiopathic dilated cardiomyopathy ... [more ▼]

In this study, color tissue Doppler imaging was used to assess global and regional mechanical dyssynchrony in patients with ischemic cardiomyopathy and those with idiopathic dilated cardiomyopathy. Potential differences in the area of latest mechanical activation could have practical implications regarding lead positioning and the success rate of biventricular pacemaker implantation.. (C) 2005 by Excerpta Medica Inc. [less ▲]

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