References of "Collette, Fabienne"
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See detailMémoire et fonctions exécutives: Nouvelles pistes de recherche
Collette, Fabienne ULg; Angel, Lucie

in Biologie Aujourd'hui (in press)

L’existence de processus communs aux différents systèmes mnésiques et au fonctionnement exécutif a été mise en évidence par des travaux menés dans les domaines de la neuroimagerie cérébrale, de l’étude ... [more ▼]

L’existence de processus communs aux différents systèmes mnésiques et au fonctionnement exécutif a été mise en évidence par des travaux menés dans les domaines de la neuroimagerie cérébrale, de l’étude des différences individuelles (principalement dans le cadre du vieillissement normal) et, dans une moindre mesure, de la neuropsychologie. Il est maintenant bien établi que le fonctionnement exécutif dépend d’un large réseau cérébral antéro-postérieur, dont certaines régions (les régions dorsolatérales et ventrolatérales moyennes, ainsi que le cortex cingulaire antérieur dorsal) sont communes non seulement à toute une série de processus exécutifs, mais également à des processus d’encodage et de récupération de l’information en mémoire épisodique et mémoire à court terme. La présence de lésions cérébrales situées dans les régions frontales a notamment pour conséquence d’altérer l’organisation stratégique de l’information à traiter (un processus exécutif), ce qui se répercute directement sur les capacités mnésiques des patients fronto-lésés. De plus, même chez des personnes exemptes de toute pathologie cérébrale, l’efficacité du fonctionnement exécutif va non seulement se répercuter sur la performance mnésique mais également moduler les réseaux cérébraux sous-jacents. Ces données témoignent donc de l’importance de relations entre processus exécutifs et mnésiques pour un fonctionnement cognitif optimal. Les développements récents en imagerie cérébrale et électrophysiologie devraient nous permettre de mieux déterminer et comprendre le mode d’action de ces relations. [less ▲]

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See detailDisrupted interaction between self and memory in patients with Alzheimer’s disease
Genon, Sarah ULg; Salmon, Eric ULg; Collette, Fabienne ULg et al

Conference (2016, July)

In humans, self and memory processes interact as evidenced by the self reference (SRE) and self reference recollection effects (SRRE). However, in patients with Alzheimer’s disease (AD), this relationship ... [more ▼]

In humans, self and memory processes interact as evidenced by the self reference (SRE) and self reference recollection effects (SRRE). However, in patients with Alzheimer’s disease (AD), this relationship can be disrupted. This was evidenced by impaired SRE and SRRE in AD for recognition of adjectives previously judged for self-relevance, as well as recall of names of people previously linked to the self. For both materials, a qualitative impairment of the recollective experience for the self-related items was also observed in AD. A neuroimaging approach suggested that reduced SRE is related to decreased grey matter volume in the lateral prefrontal cortex (lPFC). Thus, retrieval of recent self-related memories is impaired in relation to altered high-order processes in lPFC in AD. [less ▲]

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See detailLe fonctionnement exécutif dans le vieillissement normal: Quel rôle accorder aux variables attentionnelles ?
Gilsoul, Jessica ULg; Simon, Jessica ULg; Collette, Fabienne ULg

Conference (2015, December 04)

Introduction. Selon Miyake et al. (2000), le fonctionnement exécutif serait sous-tendu par trois fonctions distinctes - l’inhibition, la flexibilité et la mise à jour - alors que d’autres auteurs (Fisk ... [more ▼]

Introduction. Selon Miyake et al. (2000), le fonctionnement exécutif serait sous-tendu par trois fonctions distinctes - l’inhibition, la flexibilité et la mise à jour - alors que d’autres auteurs (Fisk & Sharp, 2004) suggèrent qu’elles seraient au nombre de quatre (coordination de tâche double). On sait aujourd’hui que l’avancée en âge s’accompagne d’un déclin exécutif. Toutefois, peu d’études ont étudié l’impact de variables non-exécutives (et plus particulièrement attentionnelles) sur la variabilité des performances exécutives dans le vieillissement. Méthode. 114 participants jeunes et 65 participants âgés ont réalisé un ensemble de tâches cognitives évaluant les quatre aspects du fonctionnement exécutif : l’inhibition (Stroop, Anti-saccade, Stop-Signal), la flexibilité (Plus et Moins, Chiffres-Lettres, Global-Local), la mise à jour (Mise à jour sonore, Mise à jour sémantique, Mise à jour de consonnes) et la coordination de tâche double (PASAT, Brown-Peterson, Attention divisée (TEA)). Par ailleurs, nous avons mesuré la vitesse de traitement de l’information (Comparaison de lettres, Stop-signal contrôle, Alerte tonique, Vitesse articulatoire), le fonctionnement attentionnel dans ses aspects d’alerte phasique, d’orientation visuelle externe (Balayage visuel, Motilité oculaire) et d’attention soutenue (Détection d’irrégularités visuelles, Détection de cibles), ainsi que le niveau d’empan. Nous avons tout d’abord comparé les performances des deux groupes sur chacune des tâches exécutives. Pour celles où nous avons observé une différence entre les groupes, nous avons tenté de déterminer si certaines variables non-exécutives pourraient expliquer une part de la variance des performances de nos participants âgés. Résultats. Les comparaisons entre groupes révèlent que les sujets jeunes ont toujours (sauf pour la tâche Stop-Signal) des performances exécutives supérieures à celles des âgés (p<0.01). Lorsque les différentes variables attentionnelles et non-attentionnelles sont introduites dans un modèle de régression multiple stepwise pas à pas, nous observons que les variables attentionnelles expliquent une part significative de la variance pour la tâche Chiffres-Lettres (alerte), la tâche de Mise à jour sémantique (orientation visuelle externe), la tâche de Mise à jour de consonnes (orientation visuelle externe) et la tâche d’attention divisée (alerte et orientation visuelle externe). Discussion. En accord avec de précédentes études, le fonctionnement exécutif décline avec l’âge. Nos résultats indiquent que le déclin de certaines fonctions (mais pas toutes) serait modulé par les capacités attentionnelles. Cette modulation attentionnelle ne serait toutefois pas un processus général, mais dépendrait des caractéristiques propres à chaque tâche. [less ▲]

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See detailMémoire et fonctions exécutives: Nouvelles pistes de recherche
Collette, Fabienne ULg

Conference (2015, October 14)

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See detailAge-related modulations in cognitive functions and its cerebral underpinnings
Collette, Fabienne ULg

Conference (2015, September 04)

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See detailSeasonality in human cognitive brain responses.
Meyer, Christelle ULg; Muto, Vincenzo ULg; Jaspar, Mathieu ULg et al

Poster (2015, September 04)

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See detailThe impact of ageing on episodic memory encoding: an fMRI study
François, Sarah ULg; Angel, Lucie; SALMON, Eric ULg et al

Poster (2015, September 04)

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See detailThe executive functioning in normal aging: Impact of the cognitive reserve
Simon, Jessica ULg; Gilsoul, Jessica ULg; Collette, Fabienne ULg

Poster (2015, September 04)

There exists a large inter-individual variability regarding the effects of aging on cognition. According to Stern (2009), people who developed a high level of reserve are more resilient to the effects of ... [more ▼]

There exists a large inter-individual variability regarding the effects of aging on cognition. According to Stern (2009), people who developed a high level of reserve are more resilient to the effects of aging that individuals with lower cognitive reserve. In this study, we describe the impact of cognitive reserve on executive functions in normal aging. Ninety healthy participants aged from 60 to 80 years were recruited. We assessed the three major executive functions: Inhibition (Stroop test, Hayling test, TAP Incompatibility subtest), Shifting (TAP Flexibility subtest, Plus-Minus task), and Updating (Letter-Number Sequencing subtest from MEM III, Letter memory task, 2-back task). Cognitive reserve was measured by questionnaires assessing educational level, occupation, leisure activities and physical activity across the life. Multiple linear regressions (p<0.05) adjusted for age, quality of sleep, processing speed showed that elderly with a high level of reserve have better performance on updating. We also assessed the effect of each factor of cognitive reserve separately after adjustment for the other. We observed that people with high level of education have better performance on flexibility (TAP Flexibility subtest and composite score) and on updating (Letter-Number Sequencing subtest, Letter memory and composite score). However, we didn’t observe any significant effect of the other factors of cognitive reserve. These results suggest that the cognitive reserve is related to abilities in some executive tests. [less ▲]

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See detailThe effect of ageing and encoding instructions on episodic memory
Hagelstein, Catherine ULg; François, Sarah ULg; Manard, Marine ULg et al

Poster (2015, May 28)

During ageing, a decline in episodic memory is observed, characterized by decreased recollection (a). In this study, we investigated the influence of encoding instructions, intentional or incidental, on ... [more ▼]

During ageing, a decline in episodic memory is observed, characterized by decreased recollection (a). In this study, we investigated the influence of encoding instructions, intentional or incidental, on the performance of younger and older adults during an episodic memory task. Twenty young volunteers (aged 18 to 30 years old) and 20 older volunteers (aged 61 to 72 years old) participated in this experiment. The stimuli consisted of 300 black-and-white drawings of common objects. The task comprised two steps. During the encoding phase, 100 items were presented once ("hard" condition) and 100 other items were presented twice ("easy" condition). During recognition, the items from the encoding phase were presented again, as well as 100 new items. In each age group, half of the participants received incidental encoding instructions (they had to make size judgements about the objects depicted) while the other half were explicitly asked to memorize the objects presented because they would be asked to recognize them later on (intentional encoding). During recognition, they performed a Remember-Know judgement for the items they believed they had seen earlier. We carried out ANOVAs in order to test for the influence of instructions, age group and number of repetitions of the items in one hand on the percentage of recollection and on the other hand on the percentage of familiarity (p<.05). Results show a significant effect of age, with more correct recollection responses in young adults, whereas more correct familiarity was found in older adults. Furthermore, it was found that the items presented twice lead to more recollection than those presented only once. Finally, these results also suggest that in the older group of participants, only for the items presented twice, intentional encoding instructions lead to more recollection and less familiarity. This finding is consistent with previous work showing that the elderly do not easily use elaborate encoding strategies, and that they need more support (here, a second exposition to the material) in order to perform a deep encoding when they are encouraged to do so with intentional learning instructions (b). (a) Bugaiska, A., Clarys, D., Jarry, C., Taconnat, L., Tapia, G., Vanneste, S., & Isingrini, M. (2007). The effect of aging in recollective experience: the processing speed and executive functioning hypothesis. Consciousness and Cognition, 16(4), 797-808. doi: 10.1016/j.concog.2006.11.007 (b) Froger, C., Bouazzaoui, B., Isingrini, M., & Taconnat, L. (2012). Study time allocation deficit of older adults: the role of environmental support at encoding? Psychology and Aging, 27(3), 577-588. doi:10.1037/a0026358 [less ▲]

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See detailThe impact of ageing on episodic memory encoding: an fMRI study
François, Sarah ULg; Angel, Lucie; Salmon, Eric ULg et al

Poster (2015, May 28)

It is now commonly accepted that a decline in episodic memory is observed with ageing: while recollection processes are impaired, familiarity seems to be relatively preserved (a). Older individuals appear ... [more ▼]

It is now commonly accepted that a decline in episodic memory is observed with ageing: while recollection processes are impaired, familiarity seems to be relatively preserved (a). Older individuals appear to recruit prefrontal areas bilaterally when their encoding is successful, while in young adults this activation is found to be left-lateralized (b). In this study, we were interested in the differences between younger and older participant regarding cerebral activity during encoding depending on whether the item elicited recollection or familiarity during the recognition phase. Twenty young volunteers (aged 19 to 29 years old) and 19 older volunteers (aged 60 to 78 years old) were presented visual stimuli depicting objects. During a first fMRI session, they were asked to make a size judgement about them. Then, in a second phase, the subjects were shown the items previously encountered during the encoding phase, as well as distractors. Participants' task was to determine which one were new and which one were seen earlier. For the latter, they also performed a Remember-Know judgement. Data were analysed using SPM8, with an event design comparing modifications in cerebral activity between the two subjects groups during encoding (1) for the items leading to recollection during the recognition phase compared to those leading to familiarity, and (2) for the items associated with familiarity during the recognition phase compared to those which were not recognized. Results show that older adults display a heightened activity in the right middle frontal gyrus, medial cingulate and paracingulate left gyri as well as in the precuneus, bilaterally when they engage recollection processes. Given that activations in these areas did not correlate with performance, they could be interepreted either as dedifferentiation or as an attempt of the ageing brain to compensate for a less elaborate encoding. However, no increase of activity was associated with familiarity processes in older adults, possibly because they are less demanding regarding attentional resources. (a) Bugaiska, A., Clarys, D., Jarry, C., Taconnat, L., Tapia, G., Vanneste, S., & Isingrini, M. (2007). The effect of aging in recollective experience: the processing speed and executive functioning hypothesis. Consciousness and Cognition, 16(4), 797-808. doi: 10.1016/j.concog.2006.11.007 (b) Duverne, S., Motamedinia, S., & Rugg, M. D. (2009). The relationship between aging, performance, and the neural correlates of successful memory encoding. Cerebral Cortex, 19(3), 733-744. doi:10.1093/cercor/bhn122 [less ▲]

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See detailExecutive functions in normal aging: Impact of cognitive reserve and objective physical activity
Gilsoul, Jessica ULg; Simon, Jessica ULg; Collette, Fabienne ULg

Poster (2015, May 28)

It is now acknowledged that there exists a large inter-individual variability in age-related cognitive changes. According to Stern (2009), the cognitive reserve built up throughout the life span will make ... [more ▼]

It is now acknowledged that there exists a large inter-individual variability in age-related cognitive changes. According to Stern (2009), the cognitive reserve built up throughout the life span will make seniors more or less resilient to the deleterious effects of aging on cognition, with seniors having a high level of cognitive reserve being more prone to successfully cope with cognitive and neuronal changes. Currently, few studies have focused on the specific effects of different factors of cognitive reserve on cognition. Consequently, the objective of this study is to determine the impact of four determinants of cognitive reserve on executive functions in normal aging. Sixty-eight healthy participants aged 60 to 80 were enrolled. Regarding executive functions, Inhibition (Stroop test, Hayling test, TAP Incompatibility subtest), Shifting (TAP Flexibility subtest, Plus-Minus task), and Updating (Letter-Number Sequencing subtest from MEM III, Letter memory task, 2-back task) were assessed (Miyake et al., 2000). Cognitive reserve was measured by questionnaires assessing educational level, occupation, leisure activities and physical activity. Moreover, an accelerometer allowed quantitative measure of physical activity by recording body movements during two weeks. Group comparisons (p<0.05) showed that seniors with a high level of cognitive reserve (measured by a global composite z-score) have better updating abilities (Letter memory task and updating composite score). In order to test the influence of each cognitive reserve factor on executive functions, simple linear regressions (p<0.05) were performed. The results showed that the educational level accounts for a significant part of the variance in flexibility (TAP Flexibility) and updating (Letter-Number sequencing, 2-back and composite score). The occupational level accounts significantly for the variance of the updating composite score. Regarding the quantitative physical activity, the mean number of minutes per day in moderate or intense physical activity significantly predicted the updating composite score. These results indicate that the level of cognitive reserve is related to abilities in some executive tests, particularly updating abilities. Importantly, all aspects of cognitive reserve are not associated with the three executive processes. This indicates a specificity of the protective effect of cognitive reserve on executive abilities. [less ▲]

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See detailThe neural bases of proactive and reactive control processes in healthy aging
Manard, Marine ULg; François, Sarah ULg; SALMON, Eric ULg et al

Poster (2015, May 28)

Background. Research on cognitive control suggests an age-related decline in proactive control abilities (an anticipatory form of control) whereas reactive control (consecutive to conflict detection ... [more ▼]

Background. Research on cognitive control suggests an age-related decline in proactive control abilities (an anticipatory form of control) whereas reactive control (consecutive to conflict detection) seems to remain intact [1]. As proactive and reactive control abilities were associated to specific brain networks [2], this study investigated age-related effects on the neural substrates associated to each kind of control. Method. A modified form of the Stroop task was administered to 16 young and 16 older adults in an event-related fMRI experiment. In this version of the Stroop task, three different contexts were created: (1) a mostly congruent context (MC, inducing reactive control) with a majority of congruent items, (2) a mostly incongruent context (MI, inducing proactive control) with mainly interfering items, (3) a neutral context (MN) with mainly neutral items. Preprocessing and statistical analyses were performed with SPM8 (p<.001 uncorrected). Results. Behavioral results (p<0.05) indicated faster processing of interferent items in the MI than MC context in young participants only. With regard to neuroimaging data, the comparison of the two groups showed that the processing of interferent items in the MI context is associated to decreased activity in (mainly right-sided) frontal and temporal areas in the older group. On the contrary, in the MC context, increased activity was observed in bilateral frontal areas for older compared to younger participants. Discussion. Behavioral results confirm that older participants have difficulties with the implementation of proactive control that is associated to decreased brain activity (compared to young participants) in areas underlying Stroop performance. However, the recruitment of supplementary frontal areas we observed in the reactive control condition suggests compensation processes. So, aging seems to differentially affect the neural networks associated to the various kinds of cognitive control. [less ▲]

Detailed reference viewed: 47 (7 ULg)
See detailThe neural bases of proactive and reactive control processes in normal aging
Collette, Fabienne ULg

Conference (2015, May 21)

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See detailThe impact of ageing on episodic memory encoding: an fMRI study
François, Sarah ULg; Angel, Lucie; Salmon, Eric ULg et al

Poster (2015, May 21)

It is now commonly accepted that a decline in episodic memory is observed with ageing: while recollection processes are impaired, familiarity seems to be relatively preserved (a). Older individuals appear ... [more ▼]

It is now commonly accepted that a decline in episodic memory is observed with ageing: while recollection processes are impaired, familiarity seems to be relatively preserved (a). Older individuals appear to recruit prefrontal areas bilaterally when their encoding is successful, while in young adults this activation is found to be left-lateralized (b). In this study, we were interested in the differences between younger and older participant regarding cerebral activity during encoding depending on whether the item elicited recollection or familiarity during the recognition phase. Twenty young volunteers (aged 19 to 29 years old) and 19 older volunteers (aged 60 to 78 years old) were presented visual stimuli depicting objects. During a first fMRI session, they were asked to make a size judgement about them. Then, in a second phase, the subjects were shown the items previously encountered during the encoding phase, as well as distractors. Participants' task was to determine which one were new and which one were seen earlier. For the latter, they also performed a Remember-Know judgement. Data were analysed using SPM8, with an event design comparing modifications in cerebral activity between the two subjects groups during encoding (1) for the items leading to recollection during the recognition phase compared to those leading to familiarity, and (2) for the items associated with familiarity during the recognition phase compared to those which were not recognized. Results show that older adults display a heightened activity in the right middle frontal gyrus, medial cingulate and paracingulate left gyri as well as in the precuneus, bilaterally when they engage recollection processes. Amongst those regions, the precuneus seems to underlie compensatory processes, allowing the elderly to perform a richer encoding, as it was previously suggested for recollection processes during recall (c). However, no increase in activity was associated with familiarity processes in older adults, possibly because they are less demanding regarding attentional resources. (a) Bugaiska, A., Clarys, D., Jarry, C., Taconnat, L., Tapia, G., Vanneste, S., & Isingrini, M. (2007). The effect of aging in recollective experience: the processing speed and executive functioning hypothesis. Consciousness and Cognition, 16(4), 797-808. doi: 10.1016/j.concog.2006.11.007 (b) Duverne, S., Motamedinia, S., & Rugg, M. D. (2009). The relationship between aging, performance, and the neural correlates of successful memory encoding. Cerebral Cortex, 19(3), 733-744. doi:10.1093/cercor/bhn122 (c) Angel, L., Bastin, C., Genon, S., Balteau, E., Phillips, C., Luxen, A., . . . Collette, F. (2013). Differential effects of aging on the neural correlates of recollection and familiarity. Cortex, 49(6), 1585-1597. doi:10.1016/j.cortex.2012.10.002 [less ▲]

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See detailInter-individual differences in sleep-wake regulation: impact on attention-related cerebral correlates
Schmidt, Christina ULg; Maire, Micheline; Reichert, Carolin et al

Conference (2015)

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See detailBrain metabolic dysfunction in Capgras delusion during Alzheimer’s disease: a positron emission tomography study
Jedidi, Haroun ULg; Daury, Noémy; Rémi, Capa et al

in American Journal of Alzheimer's Disease & Other Dementias (2015), 30(7), 699-706

Capgras delusion is characterized by the misidentification of people and by the delusional belief that the misidentified persons have been replaced by impostors, generally perceived as persecutors. Since ... [more ▼]

Capgras delusion is characterized by the misidentification of people and by the delusional belief that the misidentified persons have been replaced by impostors, generally perceived as persecutors. Since little is known regarding the neural correlates of Capgras syndrome, the cerebral metabolic pattern of a patient with probable Alzheimer’s disease (AD) and Capgras syndrome was compared with those of 24 healthy elderly subjects and 26 AD patients without delusional syndrome. Compared to the healthy and AD groups, the patient had significant hypometabolism in frontal and posterior midline structures. In light of current neural models of face perception, our patient’s Capgras syndrome may be related to impaired recognition of a familiar face, subserved by the posterior cingulate/precuneus cortex, and impaired reflection about personally relevant knowledge related to a face, subserved by the dorsomedial prefrontal cortex. [less ▲]

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