References of "Coignoul, F"
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See detailModulating skeletal muscle mass by postnatal, muscle-specific inactivation of the myostatin gene
Grobet, L.; Pirottin, Dimitri ULg; Farnir, Frédéric ULg et al

in Genesis (2003), 35(4), 227-238

By using a conditional gene targeting approach exploiting the cre-lox system, we show that postnatal inactivation of the myostatin gene in striated muscle is sufficient to cause a generalized muscular ... [more ▼]

By using a conditional gene targeting approach exploiting the cre-lox system, we show that postnatal inactivation of the myostatin gene in striated muscle is sufficient to cause a generalized muscular hypertrophy of the same magnitude as that observed for constitutive myostatin knockout mice. This formally demonstrates that striated muscle is the production site of functional myostatin and that this member of the TGFbeta family of growth and differentiation factors regulates muscle mass not only during early embryogenesis but throughout development. It indicates that myostatin antagonist could be used to treat muscle wasting and to promote muscle growth in man and animals. (C) 2003 Wiley-Liss, Inc. [less ▲]

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See detailSignes cliniques et diagnostic des tumeurs de la cavité nasale chez le chien: une analyse de 81 cas.
Clercx, Cécile ULg; Peeters, Dominique ULg; Gilbert, S. et al

in Annales de Médecine Vétérinaire (1997), 141

The paper describes clinical signs and diagnosis in 81 cases of intranasal tumors n the dog, examined at the Small Animal Clinic of the Faculty of Veterinary Medicine of the University of Liege (1990-1995 ... [more ▼]

The paper describes clinical signs and diagnosis in 81 cases of intranasal tumors n the dog, examined at the Small Animal Clinic of the Faculty of Veterinary Medicine of the University of Liege (1990-1995). Recent diagnostic techniques and therapeutic options are discussed. The most frequently encountered signs included a decreased or absence of unilateral air passage, observed in 78 cases (96%), and hemorrhagic discharge, observed in 65 cases (80%). Histopathology identified 2 benign and 79 malignant tumors, 57 epithelial and 22 mesenchymatous, including 2 lymphomas. In 74 cases, rhinoscopy identified an intranasal neoplastic mass; in the 7 remaining cases, tissular material of undetermined nature was observed, and histology of biospsied material confirmed the neoplastic nature. The time interval between the diagnosis and the death of the animal (spontaneous or by euthanasia) was longer in dogs with an intranasal sarcoma (mean time interval of 7 months) than in dogs with an intranasal carcinoma (mean time interval of 3 months). [less ▲]

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