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See detailPreparations and characterisations of semi-solid formulations containing a hydrophilic drug for vaginal administration
Coia, Isabelle ULg; Evrard, Brigitte ULg; Piette, Marie ULg

Poster (2009, April 01)

The purpose of this study is to demonstrate the effect of different types of semi-solid formulations (aqueous gels, liquid jellified emulsions and hydrophilic or lipophilic creams) for vaginal ... [more ▼]

The purpose of this study is to demonstrate the effect of different types of semi-solid formulations (aqueous gels, liquid jellified emulsions and hydrophilic or lipophilic creams) for vaginal administration on the release kinetic of a hydrophilic drug. This drug is an acidic and hydrophilic (log P (octanol/water) = -3.3) molecule with an aqueous solubility upper than 170mg/ml at pH 6-8. The formulations characterisations consisted in the in vitro evaluation of the drug release kinetic and the measure of all formulations viscosity as well as the creams stability and emulsions droplets size. [less ▲]

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