References of "Claeys, Mathieu"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailLe monoxyde d'azote exhale: un nouveau biomarqueur des pathologies respiratoires
HEINEN, Vincent ULg; Claeys, Mathieu ULg; Louis, Renaud ULg

in Revue Médicale de Liège (2006), 61(1), 37-42

There has been a growing interest for exhaled biomarkers. We review studies examining NO as a potential marker of airway inflammation, enabling noninvasive repeated monitoring of airway inflammation. The ... [more ▼]

There has been a growing interest for exhaled biomarkers. We review studies examining NO as a potential marker of airway inflammation, enabling noninvasive repeated monitoring of airway inflammation. The measurement technique has been standardized. We have determined the local normal levels for the Liege region. The exhaled NO level is elevated in asthma, and can predict asthma exacerbation. Exhaled NO has a value for the diagnosis of cystic fibrosis and primary ciliary dyskinesia. [less ▲]

Detailed reference viewed: 65 (1 ULg)
Full Text
Peer Reviewed
See detailBiologically active bisbenzylisoquinoline alkaloids from the root bark of Epinetrum villosum
Otshudi, A. L.; Apers, S.; Pieters, L. et al

in Journal of Ethnopharmacology (2005), 102(1), 89-94

Methanol and water extracts of the root of Epinetrum villosum (Exell) Troupin (Menispermaceae) were found to exhibit antimicrobial and antiplasmodial activities. Investigation of the active methanol ... [more ▼]

Methanol and water extracts of the root of Epinetrum villosum (Exell) Troupin (Menispermaceae) were found to exhibit antimicrobial and antiplasmodial activities. Investigation of the active methanol fraction led to the isolation of four bisbenzylisoquinoline alkaloids, i.e., cycleanine, cycleanine N-oxide, isochondodendrine and cocsoline. Structures were established by spectroscopic methods. Cocsoline displayed antibacterial and antifungal activities (MIC values of 1000-15.62 and 31.25 mu g/ml, respectively). Isochondodendrine was found to have the most potent antiplasmodial activity (IC50 = 0- 10 mu g/ml), whereas the IC50 on HCT-116 human colon carcinoma cells was 17.5 mu g/ml (selectivity index 175). Cycleanine acted against HIV-2 (EC50 = 1.83 mu g/ml) but was at least 10-fold less active against HIV-1. Cycleanine N-oxide showed no activity towards all tested microorganisms. (C) 2005 Elsevier Ireland Ltd. All rights reserved. [less ▲]

Detailed reference viewed: 35 (0 ULg)