  Immunohistochemical detection of incipient melanoma micrometastases. Relationship with sentinel lymph node involvement.; Pierard, Gérald  ; Pierard, Claudine et alin Melanoma Research (2005), 15(2), 107-10 It is acknowledged that tumour thickness, ulceration and lymph node invasion are the most important prognostic factors for cutaneous melanomas. Other histopathological features may also be informative ... [more ▼] It is acknowledged that tumour thickness, ulceration and lymph node invasion are the most important prognostic factors for cutaneous melanomas. Other histopathological features may also be informative. The aim of this study was to ascertain whether immunohistochemical methods can improve the detection of satellite micrometastases in primary melanoma patients. In addition, the predictive value of cutaneous satellite micrometastases for sentinel lymph node involvement was evaluated. A total of 265 primary cutaneous melanomas and 68 of the respective sentinel nodes were studied using a panel of seven antibodies directed against melanocyte-related antigens. In 12.4% of the 265 cases, small satellite micrometastases were detected by immunohistochemistry. Sentinel lymph node metastases were found in 14% of the 68 cases. Invasion of the sentinel lymph node correlated with the presence of cutaneous satellite micrometastases. It is concluded that the presence of cutaneous satellite micrometastases may be an indication for the performance of sentinel lymph node biopsy, and this finding calls for a closer follow-up of these patients. [less ▲] Detailed reference viewed: 45 (8 ULg) Effets cutanés indésirables du lithium.Paquet, Philippe ; ; Pierard, Claudine et alin Revue Médicale de Liège (2005), 60(11), 885-7 Oral administration of lithium is used as treatment in psychiatry. The drug frequently induces cutaneous side effects corresponding to acneiform or maculo-papular eruptions, psoriasis and folliculitis ... [more ▼] Oral administration of lithium is used as treatment in psychiatry. The drug frequently induces cutaneous side effects corresponding to acneiform or maculo-papular eruptions, psoriasis and folliculitis. Men are more frequently affected than women. These manifestations are characterized by the accumulation of neutrophils in the skin. Alopecia and classical drug reactions are also possible. Topical applications of lithium used to treat some dermatoses do not induce similar side effects, probably because dosages are much lower. [less ▲] Detailed reference viewed: 19 (0 ULg)Lucites par photosensibilisation.; Pierard, Claudine ; Pierard, Gérald in Revue Médicale de Liège (2005), 60 Suppl 1 There exists a series of photodermatoses due to phototoxic or photoallergic reactions. Anamnestic and clinical clues supplemented by dermatopathological examination and photobiological tests are key ... [more ▼] There exists a series of photodermatoses due to phototoxic or photoallergic reactions. Anamnestic and clinical clues supplemented by dermatopathological examination and photobiological tests are key features for reaching the correct diagnosis and the adequate choice of therapy. [less ▲] Detailed reference viewed: 31 (3 ULg)Réponses physiologiques à l'exposition solaire.; ; Pierard, Gérald in Revue Médicale de Liège (2005), 60 Suppl 1 The physiological responses to ultraviolet light exposure can be immediate, early or delayed. Typical examples include actinic erythema, suntan, the telogen actinic effluvium, ephelids, lentigines, some ... [more ▼] The physiological responses to ultraviolet light exposure can be immediate, early or delayed. Typical examples include actinic erythema, suntan, the telogen actinic effluvium, ephelids, lentigines, some melanocytic naevi, and actinic wrinkles. [less ▲] Detailed reference viewed: 102 (5 ULg)La route métastatique du mélanome.Quatresooz, Pascale ; ; Arrese Estrada, Jorge et alin Skin (2004), 7 Detailed reference viewed: 15 (3 ULg)Cutaneous psammomatous melanotic schwannoma: non-recurrence with surgical excision.; ; Arrese Estrada, Jorge et alin American Journal of Clinical Dermatology (2003), 4(11), 799-802 BACKGROUND: Melanotic schwannoma is a pigmented nerve tumor that may be located in the skin and express local aggressivity. This tumor may occur singly. It may also be part of the Carney complex which ... [more ▼] BACKGROUND: Melanotic schwannoma is a pigmented nerve tumor that may be located in the skin and express local aggressivity. This tumor may occur singly. It may also be part of the Carney complex which consists of various, but specific, tumors. OBJECTIVE: We report two cases of subcutaneous melanotic schwannoma localized on the trunk in two men aged 37 and 45 years. METHODS: Conventional histology and immunohistochemistry were performed. RESULTS: One melanotic schwannoma was associated with a cutaneous atypical myxoma and multiple melanocytic lesions, all being part of the Carney complex. The other case had no associated signs. In both cases, the melanotic schwannoma was completely excised and did not recur. CONCLUSION: Melanotic schwannoma is rare and curable by surgery. It must not be confused with malignant melanoma and other pigmented neoplasms. The Carney complex should be carefully ruled out. [less ▲] Detailed reference viewed: 30 (0 ULg)The eyelids and metastatic breast carcinoma.; Pierard, Gérald in Dermatology : International Journal for Clinical & Investigative Dermatology (2003), 206(2), 181-2 Detailed reference viewed: 4 (1 ULg)Alchimie défaillante des cytokines dans l'ulcère chronique de jambe.Franchimont, Claudine ; Henry, Frédérique ; Paquet, Philippe et alin Skin Pharmacology : The Official Journal of the Skin Pharmacology Society (2002), 5 Detailed reference viewed: 8 (0 ULg) |
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