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See detailThe histamine H3-receptor inverse agonist Pitolisant improves fear memory in mice
Brabant, Christian ULg; Charlier, Yana ULg; Tirelli, Ezio ULg

in Behavioural Brain Research (2013), 243

Numerous studies have demonstrated that brain histamine plays a crucial role in learning and memory and histamine H3 receptor inverse agonists (H3R inverse agonists) have been proposed to treat cognitive ... [more ▼]

Numerous studies have demonstrated that brain histamine plays a crucial role in learning and memory and histamine H3 receptor inverse agonists (H3R inverse agonists) have been proposed to treat cognitive disorders. Pitolisant (BF2.649, 1-{3-[3-(4-chlorophenyl)propoxy]propyl}piperidine, hydrochloride) was the first H3R inverse agonist that has been tested in human trials and is well tolerated. The present study investigated whether Pitolisant (0.625–20 mg/kg, i.p.) improves consolidation and reconsolidation processes in the fear conditioning task in female C57BL/6J mice. We also tested whether Pitolisant reverses memory deficits induced by the non-competitive N-methyl-d-aspartate (NMDA) antagonist dizocilpine (MK-801). Our results indicate that post-training systemic injections of Pitolisant facilitated consolidation of contextual fear memory and reversed amnesia induced by an i.p. injection of 0.12 mg/kg dizocilpine. In addition, none of the doses of Pitolisant we have tested after reactivation (reexposure to the context in which training took place 48 h earlier) affected reconsolidation, whereas dizocilpine disrupted it. However, Pitolisant was able to reverse the deficit in reconsolidation induced by 0.12 mg/kg dizocilpine. The present results are the first demonstration that Pitolisant is effective in improving consolidation processes in the fear condition task and add further evidence to its potential for treating cognitive disorders. [less ▲]

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See detailDevelopment and organization of executive functions in 4-to 11 year-old children: A factor study.
Catale, Corinne ULg; Collette, Fabienne ULg; Lejeune, Caroline ULg et al

in Books of Abstract: Annual Meeting of the Belgian Association for Psychological Science (2011)

Executive functioning (EF) is an umbrella term used to refer to the higher-order cognitive processes whose principal function is to facilitate the adaptation of an individual to new and non-routine ... [more ▼]

Executive functioning (EF) is an umbrella term used to refer to the higher-order cognitive processes whose principal function is to facilitate the adaptation of an individual to new and non-routine situations. In the present study, inhibition, mental flexibility, and working memory were assessed through 6 executive tasks administered to 329 children aged from 4 to 11 years, in order to examine the development and organization of executive functioning in both early and middle childhood. Results reveal specific developmental trends for each component, with a period of rapid general development during the preschool period. Confirmatory factor analyses were used to examine the organization of EF in our sample. First, the poorness of fit of the unitary model was found for both groups, confirming the fractionated nature of EF in preschoolers as well as in older children. Second, the analyses confirmed the adequacy of the fit of the three-dimensional model (i.e., inhibition, flexibility, and working memory), while also indicating that other specific two-dimensional models gave reasonable fits to the data from both age groups. The factor structure obtained supports both the unitary and diversity nature of the executive organisation during early and middle childhood. Furthermore, our data suggest a progressive differentiation of executive processes (in particular flexibility and working memory) in the course of development. [less ▲]

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See detailThe H(3) antagonist thioperamide reveals conditioned preference for a context associated with an inactive small dose of cocaine in C57BL/6J mice
Brabant, Christian ULg; Charlier, Yana ULg; Quertemont, Etienne ULg et al

in Behavioural Brain Research (2005), 160(1), 161-168

The histaminergic system has been speculated to be involved in the inhibitory control of drug reward, H-1 and H-2 antagonists having been found to potentiate conditioned place preference induced by ... [more ▼]

The histaminergic system has been speculated to be involved in the inhibitory control of drug reward, H-1 and H-2 antagonists having been found to potentiate conditioned place preference induced by morphine or cocaine. In contrast, the role of H-3 receptors in cocaine-induced place preference is still unknown. The present study tested the effects of thioperamide (0, 10 and 20 mg/kg, i.p.), an H-3 autoreceptor antagonist, on the development of a conditioned place preference induced by cocaine (0, 2 and 8 mg/kg, i.p.) in C57BL/6J mice. Thioperamide was injected 10 min before each cocaine-pairing session. The activity scores recorded on the first cocaine-pairing session were also used to test the effects of thioperamide on cocaine-induced locomotor activity. Thioperamide alone had no reinforcing effects and did not affect the conditioned place preference induced by 8 mg/kg cocaine. However, thioperamide dose-dependently revealed a conditioned place preference induced by 2 mg/kg cocaine, a dose that was inactive per se. Finally, thioperamide dose-dependently potentiated the stimulant effects of cocaine, in spite of its slight hypolocomotor effect when given alone. Our results strongly suggest that H3 antagonists potentiate the stimulant and reinforcing effects of cocaine in mice. © 2004 Elsevier B.V. All rights reserved. [less ▲]

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