References of "Chantraine, Frédéric"
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See detailL'utilisation du ratio sFlt-1/PlGF dans la prééclampsie: une analyse rétrospective monocentrique
Verbeurgt, Lievine ULiege; CHANTRAINE, Frédéric ULiege; DE MARCHIN, Jérôme et al

in Revue Médicale de Liège (in press)

La fms-like tyrosine kinase 1 soluble (sFlt-1) est un facteur anti-angiogénique libéré en quantité excessive dans la prééclampsie (PE) et impliqué dans la dysfonction endothéliale. Il est comparé au ... [more ▼]

La fms-like tyrosine kinase 1 soluble (sFlt-1) est un facteur anti-angiogénique libéré en quantité excessive dans la prééclampsie (PE) et impliqué dans la dysfonction endothéliale. Il est comparé au facteur de croissance placentaire pro-angiogénique (PlGF) qui diminue dans la PE. Le ratio sFlt-1/PlGF est présenté dans la littérature comme outil dans la prédiction de la prééclampsie. Un ratio < 38 confirme l’absence de prééclampsie à court-terme. Un ratio ≥ 85 dans la PE précoce (avant 34 semaines aménorrhée (SA)) et ≥ 110 dans le «late onset» (> 34 semaines d’aménorhhée) peut poser le diagnostic de prééclampsie. Dans cette étude rétrospective monocentrique, le ratio sFlt-1/PlGF a été dosé chez 183 patientes à risque dont 67 ont présenté une prééclampsie. Le ratio sFlt-1/PlGF médian pour toutes les patientes évaluées est 100,3. Le ratio médian pour les patientes ayant déclaré une prééclampsie (N=67) est 212,7 alors que celui des femmes sans prééclampsie (N=116) est de 35,4. En accord avec ces analyses, un ratio sFlt-1/PlGF ≥ 38 possède une sensibilité égale à 95,5% et une spécificité égale à 73,3%. Les valeurs prédictives positive (VPP) et négative (VPN) sont, respectivement, 67,4% et 96,6%. Ces résultats suggèrent que le ratio sFlt-1/PlGF peut être une aide dans le diagnostic de la prééclampsie [less ▲]

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See detailComputed tomography and ultrasound to determine fetal head station.
Tutschek, B.; Braun, T.; CHANTRAINE, Frédéric ULiege et al

in Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (2017), 49(2), 279-280

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See detailRe: Prediction of delivery time in second stage of labor using transperineal ultrasound.
Tutschek, B.; Braun, T.; CHANTRAINE, Frédéric ULiege et al

in Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (2017), 49(5), 663-664

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See detailDysregulated circulating miRNAs in pre-eclampsia
Tebache, Linda; Munaut, Carine ULiege; Blacher, Silvia ULiege et al

Conference (2016, September 25)

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See detailSoluble fms-Like Tyrosine Kinase-1-to-Placental Growth Factor Ratio and Time to Delivery in Women With Suspected Preeclampsia.
Zeisler, Harald; Llurba, Elisa; CHANTRAINE, Frédéric ULiege et al

in Obstetrics & Gynecology (2016), 128(2), 261-9

OBJECTIVE: To assess the association of a serum soluble fms-like tyrosine kinase 1-to-placental growth factor (sFlt-1-to-PlGF) ratio of greater than 38 with time to delivery and preterm birth. METHODS ... [more ▼]

OBJECTIVE: To assess the association of a serum soluble fms-like tyrosine kinase 1-to-placental growth factor (sFlt-1-to-PlGF) ratio of greater than 38 with time to delivery and preterm birth. METHODS: Secondary analysis of an observational cohort study that included women 18 years of age or older from 24 to 36 6/7 weeks of gestation at their first study visit with suspected (not confirmed) preeclampsia. Participants were recruited from December 2010 to January 2014 at 30 sites in 14 countries. A total of 1,041 women were included in time-to-delivery analysis and 848 in preterm birth analysis. RESULTS: Women with an sFlt-1-to-PlGF ratio greater than 38 (n=250) had a 2.9-fold greater likelihood of imminent delivery (ie, delivery on the day of the test) (Cox regression hazard ratio 2.9; P<.001) and shorter remaining time to delivery (median 17 [interquartile range 10-26] compared with 51 [interquartile range 30-75] days, respectively; Weibull regression factor 0.62; P<.001) than women with an sFlt-1-to-PlGF ratio of 38 or less, whether or not they developed preeclampsia. For women who did not (n=842) and did develop preeclampsia (n=199), significant correlations were seen between an sFlt-1-to-PlGF ratio greater than 38 and preterm birth (r=0.44 and r=0.46; both P<.001). Among women who did not develop preeclampsia, those who underwent iatrogenic preterm delivery had higher median sFlt-1-to-PlGF ratios at their first visit (35.3, interquartile range 6.8-104.0) than those who did not (8.4, interquartile range 3.4-30.6) or who delivered at term (4.3, interquartile range 2.4-10.9). CONCLUSIONS: In women undergoing evaluation for suspected preeclampsia, a serum sFlt-1-to-PlGF ratio greater than 38 is associated with a shorter remaining pregnancy duration and a higher risk of preterm delivery. [less ▲]

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See detailPredictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia.
Zeisler, Harald; Llurba, Elisa; CHANTRAINE, Frédéric ULiege et al

in New England Journal of Medicine (2016), 374(1), 13-22

BACKGROUND: The ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) is elevated in pregnant women before the clinical onset of preeclampsia, but its predictive value in ... [more ▼]

BACKGROUND: The ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) is elevated in pregnant women before the clinical onset of preeclampsia, but its predictive value in women with suspected preeclampsia is unclear. METHODS: We performed a prospective, multicenter, observational study to derive and validate a ratio of serum sFlt-1 to PlGF that would be predictive of the absence or presence of preeclampsia in the short term in women with singleton pregnancies in whom preeclampsia was suspected (24 weeks 0 days to 36 weeks 6 days of gestation). Primary objectives were to assess whether low sFlt-1:PlGF ratios (at or below a derived cutoff) predict the absence of preeclampsia within 1 week after the first visit and whether high ratios (above the cutoff) predict the presence of preeclampsia within 4 weeks. RESULTS: In the development cohort (500 women), we identified an sFlt-1:PlGF ratio cutoff of 38 as having important predictive value. In a subsequent validation study among an additional 550 women, an sFlt-1:PlGF ratio of 38 or lower had a negative predictive value (i.e., no preeclampsia in the subsequent week) of 99.3% (95% confidence interval [CI], 97.9 to 99.9), with 80.0% sensitivity (95% CI, 51.9 to 95.7) and 78.3% specificity (95% CI, 74.6 to 81.7). The positive predictive value of an sFlt-1:PlGF ratio above 38 for a diagnosis of preeclampsia within 4 weeks was 36.7% (95% CI, 28.4 to 45.7), with 66.2% sensitivity (95% CI, 54.0 to 77.0) and 83.1% specificity (95% CI, 79.4 to 86.3). CONCLUSIONS: An sFlt-1:PlGF ratio of 38 or lower can be used to predict the short-term absence of preeclampsia in women in whom the syndrome is suspected clinically. (Funded by Roche Diagnostics.). [less ▲]

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See detailRe: Angle of fetal head progression measured using transperineal ultrasound as a predictive factor of vacuum extraction failure.
Tutschek, B.; Braun, T.; CHANTRAINE, Frédéric ULiege et al

in Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (2016), 48(5), 668-669

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See detailProposal for standardized ultrasound descriptors of abnormally invasive placenta (AIP)
Collins, Sally; Anna, Ashcroft; Braun, Thorsten et al

in Ultrasound in Obstetrics & Gynecology (2016)

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See detailAnti-D Prophylaxis Reviewed in the Erea of Foetal RHD Genotyping
MINON, Jean-Marc; GERARD, CH; CHANTRAINE, Frédéric ULiege et al

in Journal of Blood Disorders & Transfusion (2015), 6(5),

A few years ago, the prevention of anti-D immunization was currently based on systematic postnatal prophylaxis associated with targeted antenatal injection in high-risk situations of foeto-maternal ... [more ▼]

A few years ago, the prevention of anti-D immunization was currently based on systematic postnatal prophylaxis associated with targeted antenatal injection in high-risk situations of foeto-maternal haemorrhage. The failures of prevention are mainly due to the non-respect of established guidelines for RhIG prophylaxis, and to spontaneous undetected foetal-maternal haemorrhages without any obvious cause during the third trimester of pregnancy. In order to reduce the rate of residual post-pregnancy anti-D immunization, several countries decided to associate the classical prophylaxis to a routine antenatal anti-D prophylaxis (RAADP) during the 28th or 29th week of gestation. Since about ten years, the foetal RHD genotyping in maternal plasma enables us to limit the antenatal prophylaxis only to those D- women carrying a D+ foetus. This paper deals with: the advantages of an antenatal prevention in the light of non invasive foetal RHD genotyping, the rules rendering prevention protocols efficient whatever the algorithm applied, and the recommended immuno-haematology follow-up of women who have received RhIG. [less ▲]

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See detailImplementation of the sFlt-1/PlGF ratio for prediction and diagnosis of pre-eclampsia in singleton pregnancy: implications for clinical practice
Stepan, Holger; Herraiz, Ignaz; Schlembach, Dietmar et al

in Ultrasound in Obstetrics & Gynecology (2015), 45(3), 241-6

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See detailExpulsion of a uterine myoma in a patient treated with ulipristal acetate
CHANTRAINE, Frédéric ULiege; POISMANS, Gaëlle ULiege; Nwachuku, Julia et al

in Clinical Case Reports (2015)

Description of a spontaneous expulsion of a submucosal myoma in a patient treated with ulipristal acetate.

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See detailIN UTERO INFECTION BY SCHMALLENBERG VIRUS INDUCES ARTHROGRYPOSIS MULTIPLEXA CONGENITA IN OVINE FETUSES
Boseret, Geraldine; Claine, Francoise; Coupeau, Damien et al

Poster (2014, December)

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See detailPREDICTION OF SHORT-TERM OUTCOME IN PREGNANT WOMEN WITH SUSPECTED PREECLAMPSIA: THE PROGNOSIS STUDY
Zeisler, Harald; Llurba, Elisa; CHANTRAINE, Frédéric ULiege et al

Poster (2014, December)

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See detailSonographische Diagnostik bei abnorm invasiver Plazenta
Tutschek, Boris; CHANTRAINE, Frédéric ULiege; Braun, Thorsten et al

in Der Gynäkologe (2014), 47

Abnormally invasive placenta (AIP or “mor- bidly adherent placenta”) significantly con- tributes to maternal morbidity and mortality , potentially causing severe hemorrhage at de- livery. Previous uterine ... [more ▼]

Abnormally invasive placenta (AIP or “mor- bidly adherent placenta”) significantly con- tributes to maternal morbidity and mortality , potentially causing severe hemorrhage at de- livery. Previous uterine surgery is the main risk factor. It may be speculated that with the rise in Caesarean delivery rates the incidence of AIP will also increase. Prenatal detection of AIP is mandatory to reduce the perinatal morbidity. Obstetrical ultrasound should be used as a screening tool for AIP. There are well known sonographic signs in B-mode, color Doppler and dynamic ultrasound that form the basis for prenatal detection. This review highlights these ultrasound markers and shows clinical examples. [less ▲]

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See detailResektion der Plazentahaftstelle bei pathologischer Plazentainvasion
CHANTRAINE, Frédéric ULiege; PETIT, Philippe ULiege; Langhoff-Roos, Jens

in Der Gynäkologe (2014), 47

Abnormally invasive placenta (AIP) is a rare condition with an increasing incidence. Severe cases, such as placenta percreta, can cause massive peripartal bleeding linked to an elevated maternal morbidity ... [more ▼]

Abnormally invasive placenta (AIP) is a rare condition with an increasing incidence. Severe cases, such as placenta percreta, can cause massive peripartal bleeding linked to an elevated maternal morbidity and even mortality. Prenatal AIP screening using ultra- sound allows referral to a specialized centre in suspected cases in order to optimize the chances for mother and child. Caesarean hys- terectomy or placenta in situ methods are the currently known and recommended management options. This article describes the techniques of elective resection of the placental bed including AIP which allow conserving the uterus and preserving fertility. Furthermore, it seems that morbidity of this technique is lower when compared to the standard treatment options. Whether this is due to a selection of less severe AIP cases for resection or really represents a lower complication rate in cases of resection has to be demonstrated by further prospective studies. [less ▲]

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See detailAn unusual presentation for congenital cytomegalovirus infection
Hennuy, Nadège; PIERART; Demarche, Martine et al

Poster (2014)

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See detailAIP (abnormally invasive placenta) – from a retained placenta to destruction of the uterine wall
Langhoff-Roos, Jens; CHANTRAINE, Frédéric ULiege; Geirrson, Reynir

in Acta Obstetricia et Gynecologica Scandinavica (2013), 92(4), 367-8

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See detailIFPA Meeting 2012 Workshop Report III: trophoblast deportation, gestational trophoblastic disease, placental insufficiency and fetal growth restriction, trophoblast over-invasion and accreta-related pathologies, placental thrombosis and fibrinolysis.
Al-Khan, A.; Bulmer, J. N.; CHANTRAINE, Frédéric ULiege et al

in Placenta (2013), 34 Suppl

Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2012 there were twelve themed workshops, five of which are summarized in this ... [more ▼]

Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2012 there were twelve themed workshops, five of which are summarized in this report. These workshops related to various aspects of placental biology but collectively covered areas of clinical research and pregnancy disorders: 1) trophoblast deportation; 2) gestational trophoblastic disease; 3) placental insufficiency and fetal growth restriction; 4) trophoblast overinvasion and accreta-related pathologies; 5) placental thrombosis and fibrinolysis. [less ▲]

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