 Usefulness of basement membrane markers in tumoural pathology; ; et al in Journal of Pathology (The) (1985), 145(4), 283-96 The distribution of basement membrane (BM) markers, type IV collagen, laminin (LM), heparan sulphate proteoglycan (HSP) and fibronectin (FN) has been studied by indirect immunofluorescence using specific ... [more ▼] The distribution of basement membrane (BM) markers, type IV collagen, laminin (LM), heparan sulphate proteoglycan (HSP) and fibronectin (FN) has been studied by indirect immunofluorescence using specific antibodies, in tumoural pathology. The disrupted pattern of BM by these markers in severe dysplastic lesions of the breasts, the bronchi and uterine cervix provides evidence for malignancy. In invasive carcinomas, there is generally a loss of these BM components, with FN persisting in the stroma. The loss of these markers in BM is concomitant and superimposable in double staining studies. In embryonic tumours, the presence of BM markers is related to a mesenchymal differentiation of malignant cells with pericellular FN and/or maturation towards organoid structures with BM. In sarcomas, there is a loss of the pericellular BM staining around most transformed muscular and Schwann cells and adipocytes. The persistence of this labelling in some well-differentiated areas can help to diagnose the nature of the sarcoma. The persistence of intercellular filaments of FN corresponds to the mesenchymal and/or sarcomatous nature of undifferentiated anaplastic proliferations. [less ▲] Detailed reference viewed: 2 (0 ULg)Distribution of laminin, a basement membrane glycoprotein in epithelial proliferations. A preliminary study in the breast, the lungs and uterine cervix.; ; et al in Collagen and Related Research (1983), 3(1), 25-31 Distribution of laminin, a basement membrane glycoprotein, was studied by an indirect immunofluorescence technique in benign, dysplastic and malignant lesions of breast, lungs and uterine cervix as ... [more ▼] Distribution of laminin, a basement membrane glycoprotein, was studied by an indirect immunofluorescence technique in benign, dysplastic and malignant lesions of breast, lungs and uterine cervix as compared with normal tissues. Laminin was present with a linear and continuous staining in epithelial and vascular basement membranes in normal tissues, benign and dysplastic lesions and in in situ carcinomas of the uterine cervix. By contrast, laminin was absent or very irregularly distributed around malignant infiltrating tumoral clusters. Of particular interest was the linear and disrupted labeling observed in intra-epithelial carcinomas of breast and bronchi. Loss of laminin in these conditions could be related to a potential tumoral invasion. [less ▲] Detailed reference viewed: 2 (0 ULg)Distribution of laminin in tumor pathology, Immunofluorescence study; ; Foidart, Jean-Michel  in Archives d'Anatomie et de Cytologie Pathologiques (1983), 31(4), 211-6 Detailed reference viewed: 2 (0 ULg) |
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