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See detailThe lymphotoxin-β receptor induces different patterns of gene expression via two NF-κB pathways
Dejardin, Emmanuel ULg; Droin, Nathalie; Delhase, Mireille et al

Conference (2009, October 30)

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See detailThe lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways.
Dejardin, Emmanuel ULg; Droin, Nathalie; Delhase, Mireille et al

in Immunity (2002), 17

The lymphotoxin-beta receptor (LTbetaR) plays critical roles in inflammation and lymphoid organogenesis through activation of NF-kappaB. In addition to activation of the classical NF-kappaB, ligation of ... [more ▼]

The lymphotoxin-beta receptor (LTbetaR) plays critical roles in inflammation and lymphoid organogenesis through activation of NF-kappaB. In addition to activation of the classical NF-kappaB, ligation of this receptor induces the processing of the cytosolic NF-kappaB2/p100 precursor to yield the mature p52 subunit, followed by translocation of p52 to the nucleus. This activation of NF-kappaB2 requires NIK and IKKalpha, while NEMO/IKKgamma is dispensable for p100 processing. IKKbeta-dependent activation of canonical NF-kappaB is required for the expression but not processing of p100 and for the expression of proinflammatory molecules including VCAM-1, MIP-1beta, and MIP-2 in response to LTbetaR ligation. In contrast, IKKalpha controls the induction by LTbetaR ligation of chemokines and cytokines involved in lymphoid organogenesis, including SLC, BLC, ELC, SDF1, and BAFF. [less ▲]

Detailed reference viewed: 7 (4 ULg)
Peer Reviewed
See detailThe lymphotoxin-β receptor induces different patterns of gene expression via two NF-κB pathways
Dejardin, Emmanuel ULg; Droin, Nathalie; Delhase, Mireille et al

Conference (2002)

Detailed reference viewed: 4 (0 ULg)