NCA synthesis of an N-w-[18F]fluoroethyl analog of altanserine, a serotonine S2 receptor ligand.

in Journal of Labelled Compounds & Radiopharmaceuticals (1991), 30

NCA asymmetric synthesis of 6-[18F]fluoro-L-dopa.

in Journal of Labelled Compounds & Radiopharmaceuticals (1991), 30

Synthesis and preliminary animal studies of [131I]iodotropapride: a cerebral dopamine D2 receptor ligand.

in Journal of Labelled Compounds & Radiopharmaceuticals (1991), 30

Serotonine-S2 receptor imaging with [18F]altanserin and PET. Results in young normal controls.

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1991), 32

2 and 4-[18F]fluorotropapride, two specific D2 receptor ligand for PET.

in European Journal of Nuclear Medicine (1991), 18

No-Carrier-Added Regioselective Preparation of 6-[18f]Fluoro-L-Dopa

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1990), 31(7), 1247-51

This paper describes the preparation of 6-[18F]fluoro-L-dopa by a no-carrier-added method based on the nucleophilic displacement of nitro groups of two commercially available substrates, 3,4-dimethoxy-2 ... [more ▼]

This paper describes the preparation of 6-[18F]fluoro-L-dopa by a no-carrier-added method based on the nucleophilic displacement of nitro groups of two commercially available substrates, 3,4-dimethoxy-2-nitrobenzaldehyde (nitroveratraldehyde) and 6-nitropiperonal. Fluorination was conducted in DMSO with fluorine-18 (18F) in the presence of the aminopolyether Kryptofix 222 and potassium carbonate. The condensation of the fluorinated aldehydes with phenyloxazolone and the subsequent hydrolysis with HI/P yield, after purification by HPLC, only the 6-(D, L) isomers. The racemic mixture (50/50) was resolved on an analytical scale chiral column. The method, which requires 100 min (EOB) to complete, produces 6-[18F]fluoro-L-dopa with a decay-corrected radiochemical yield of 10%, an enantiomeric purity greater than 99%, and a specific activity of 1.2 Ci/mumole. [less ▲]

Development of a new in vivo tracer of the cerebral pH.

in Journal of Cerebral Blood Flow & Metabolism (1989), 9S1

A New Route for the Synthesis of [18f]Fluoroaromatic Substituted Amino Acids: No Carrier Added L-P-[18f]Fluorophenylalanine

in International Journal of Radiation Applications and Instrumentation. Part A : Applied Radiation and Isotopes (1987), 38(12), 1033-8

L-p-[18F]fluorophenylalanine was designed as a potential marker for probing protein synthesis in the human brain by positron emission tomography. This radiotracer has been synthesized using nucleophilic ... [more ▼]

L-p-[18F]fluorophenylalanine was designed as a potential marker for probing protein synthesis in the human brain by positron emission tomography. This radiotracer has been synthesized using nucleophilic displacement of the activated nitro group of p-nitrobenzaldehyde by NCA 18F- obtained from the 18O (p, n) reaction on enriched water. The L-form of the [18F]fluoroamino acid can be separated on an analytical scale chiral column. A typical production run of 22.2 GBq (600 mCi) of 18F obtained after a 10 microA.h bombardment of 18 MeV protons on 99.8% 18O-enriched water leads to a batch of 1.11 GBq (30 mCi) of NCA L-p-[18F]fluorophenylalanine after a total synthesis time of 120 min. [less ▲]

Two step synthesis of a new Na channel marker by mild oxidation of tetrodotoxin, monitored by HPLC and, coupling of (3H) ethylene diamine of high specific radioactivity

Poster (1984, February 25)