References of "CHARLIER, Corinne"
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See detailThe current environmental levels of endocrine disruptors (mercury, cadmium, organochlorine pesticides and PCBs) in a Belgian adult population and their predictors of exposure
PIRARD, Catherine ULiege; Compere, Stéphanie; Firquet, Cathy et al

in International Journal of Hygiene and Environmental Health (in press)

A human biomonitoring study was carried out measuring the levels of endocrine disruptors in 252 participants (18-76 years old) recruited between February and May 2015 from the general population of Liege ... [more ▼]

A human biomonitoring study was carried out measuring the levels of endocrine disruptors in 252 participants (18-76 years old) recruited between February and May 2015 from the general population of Liege Province (Belgium). In this study, we reported the recent levels of cadmium and mercury in urine, some organochlorine pesticides and polychlorinated biphenyls (PCBs) in serum, and their relations to demographic characteristics, lifestyle behaviors and dietary habits. The median urinary levels of mercury and cadmium were 0.81 µg/l and <0.5µg/l respectively. The mercury levels were higher in participants having at least 3 dental amalgams, and consuming sea fish more than once a week. Although our mercury levels in most participants were lower than some health-based guidelines, they were higher than in our neighboring countries where ban or restrictions on the dental amalgams use were implemented. Urinary cadmium levels in current smokers were significantly higher than former or never smokers, as well as non-smokers for passively exposed vs non-exposed ones. Median PCB-153 and -180 serum levels were 53.8 and 41.1 ng/g lipid respectively, but PCB-138 was below the limit of quantification of 0.15 µg/l in 49% of the samples. Among the organochlorine pesticides, 4,4’-dichlorodiphenyldichloroethylene (4,4’-DDE), beta-hexachlorohexane and hexachlorobenzene were positively detected respectively in 48%, 49% and 37% of the serum samples. Eventhough, a dramatic decrease in organochlorines levels was observed, at least 1 pesticide or PCB was detected in 96% of our population, and more than 50% of our samples were contaminated by 4 or more organochlorines. Age, body mass index, and breastfeeding duration were the most predictive determinants of pesticide or PCB serum concentrations, but not dietary habits. [less ▲]

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See detailDetermination of phenolic organohalogens in human serum from a Belgian population and assessment of parameters affecting the human contamination
Dufour, Patrice ULiege; PIRARD, Catherine ULiege; CHARLIER, Corinne ULiege

in Science of the Total Environment (2017), 599-600

Many in vitro or in vivo studies highlighted the potential deleterious effects of phenolic organohalogenated compounds (POHs) on the health, particularly on the thyroid system homeostasis, however few ... [more ▼]

Many in vitro or in vivo studies highlighted the potential deleterious effects of phenolic organohalogenated compounds (POHs) on the health, particularly on the thyroid system homeostasis, however few large scale human epidemiological studies have been carried out, especially in Europe. Further studies monitoring the human contamination by POHs, the sources of exposure and the influence of these compounds on thyroid health are still needed. Therefore we determined the concentrations of 16 POHs (pentachlorophenol (PCP), tetrabromobisphenol A (TBBPA), 4 bromophenols (BPs), 3 hydroxy-polybromodiphenylethers (OH-PBDEs) and 7 hydroxy-polychlorobiphenyls (OH-PCBs)) in serum from 274 people aged from 18 to 76 years old living in Liege (Belgium) and the surrounding area. A questionnaire about their alimentary habits, life style and home environment was also administered to the volunteers. The predominant compound measured in the population was PCP (median concentration of 593.0 pg mL−1). 4-OH-CB 107, 4-OH-CB 146 and 4-OH-CB 187 were detected in all samples and contributed for 75% of the sum of OH-PCBs (ΣOH-PCBs). The median measured in our population for ΣOH-PCBs was 143.7 pg mL−1. TBBPA and 2,4,6-tribromophenol were detected in 31% and 63.8% of the samples respectively while the detection frequency observed for the other BPs and the OH-PBDEs was close to zero. We computed multivariate regression models in order to assess the influence of demographic and lifestyle parameters on the PCP and ΣOH-PCBs contamination levels. Significant correlation was found between the PCP concentration and sex, smoker status, sea fish consumption and level of education, although the model seemed to be a poor (R2 = 0.14) predictor of the PCP concentration. The model computed for ΣOHPCBs was more explanatory (R2 = 0.61) and involved age, BMI and sea fish consumption. Finally, we assessed the parameters affecting the ΣOH-PCBs/ΣPCBs ratio. The model proposed involved age, BMI, smoker status and parent PCB level, and explained 41% of the variability of the ΣOH-PCBs/ΣPCBs ratio. [less ▲]

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See detailQualité de l'air intérieur en Belgique
Bladt, Sandrine; Bouland, Catherine; Casimir, Georges et al

Report (2017)

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See detailLes retardateurs de flamme bromés : impact sur l'environnement et la santé des individus exposés
Dufour, Patrice ULiege; Charlier, Corinne ULiege

in Annales de Biologie Clinique (2017), 75(2), 146-157

Depuis l’antiquité, l’homme utilise des moyens chimiques pour protéger ses biens des incendies. Efficaces et faciles d’emploi, les retardateurs de flamme bromés sont utilisés depuis plusieurs décennies de ... [more ▼]

Depuis l’antiquité, l’homme utilise des moyens chimiques pour protéger ses biens des incendies. Efficaces et faciles d’emploi, les retardateurs de flamme bromés sont utilisés depuis plusieurs décennies de façon massive dans l’industrie du plastique. À l’instar d’autres composés organohalogénés, les retardateurs de flamme bromés sont très persistants dans l’environnement et capables de s’accumuler le long de la chaîne alimentaire. De nombreux auteurs ont mis en évidence leur présence dans notre environnement, chez différentes espèces animales mais également dans le sérum humain. Plus inquiétant encore, l’homme est exposé à ces polluants dès la grossesse et par la suite via le lait maternel. Cette exposition pourrait avoir des conséquences sur notre santé. De nombreuses études in vitro, in vivo ou épidémiologiques ont mis en lumière une influence néfaste des retardateurs de flamme bromés sur notre système endocrinien, principalement au niveau de la fonction thyroïdienne mais également de la reproduction, du neurodéveloppement chez l’enfant et du métabolisme avec un risque accru de développer un diabète. Si une certaine prise de conscience a déjà eu lieu au niveau des autorités et de certaines grandes entreprises, de nouvelles études sont nécessaires pour confirmer les tendances déjà dégagées, élucider les mécanismes sous-jacents et déterminer s’il existe des synergies avec d’autres polluants tels que par exemple les PCB. [less ▲]

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See detailBiocompatibility of polymer-infiltrated-ceramicnetwork (PICN) materials with Human Gingival Keratinocytes (HGKs)
GRENADE, Charlotte ULiege; Gillet, Marie-Claire ULiege; PIRARD, Catherine ULiege et al

in Dental Materials (2017), 33

Objective. Biocompatibility of polymer-infiltrated-ceramic-network (PICN) materials, a new class of CAD–CAM composites, is poorly explored in the literature, in particular, no data are available regarding ... [more ▼]

Objective. Biocompatibility of polymer-infiltrated-ceramic-network (PICN) materials, a new class of CAD–CAM composites, is poorly explored in the literature, in particular, no data are available regarding Human Gingival Keratinocytes (HGK). The first objective of this study was to evaluate the in vitro biocompatibility of PICNs with HGKs in comparison with other materials typically used for implant prostheses. The second objective was to correlate results with PICN monomer release and indirect cytotoxicity. Methods. HGK attachment, proliferation and spreading on PICN, grade V titanium (Ti), yttrium zirconia (Zi), lithium disilicate glass-ceramic (eM) and polytetrafluoroethylene (negative control) discs were evaluated using a specific insert-based culture system. For PICN and eM samples, monomer release in the culture medium was quantified by high performance liquid chromatography and indirect cytotoxicity tests were performed. Results. Ti and Zi exhibited the best results regarding HGK viability, number and coverage. eM showed inferior results while PICN showed statistically similar results to eM but also to Ti regarding cell number and to Ti and Zi regarding cell viability. No monomer release from PICN discs was found, nor indirect cytotoxicity, as for eM. Significance. The results confirmed the excellent behavior of Ti and Zi with gingival cells. Even if polymer based, PICN materials exhibited intermediate results between Ti–Zi and eM. These promising results could notably be explained by PICN high temperature–high pressure (HT–HP) innovative polymerization mode, as confirmed by the absence of monomer release and indirect cytotoxicity [less ▲]

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See detailLa cigarette électronique : état des connaissances à propos des aspects toxicologiques
DEVILLE, Marine ULiege; CHARLIER, Corinne ULiege

in Revue Médicale de Liège (2017), 72(1), 20-24

La cigarette électronique, aussi appelée e-cigarette, est présentée comme une alternative au tabagisme qui serait moins nocive pour la santé. Son fonctionnement repose sur la conversion d’un liquide en ... [more ▼]

La cigarette électronique, aussi appelée e-cigarette, est présentée comme une alternative au tabagisme qui serait moins nocive pour la santé. Son fonctionnement repose sur la conversion d’un liquide en vapeur, sous l’action de la chaleur générée par un filament présent dans un atomiseur. Le liquide est majoritairement composé de propylène glycol et/ou de glycérine, utilisé(s) pour produire l’effet de fumée, auxquels s’ajoutent des arômes et, éventuellement, de la nicotine. A l’exception de cette dernière, potentiellement létale lorsqu’elle est ingérée à haute dose, ces constituants sont généralement reconnus comme sans danger. Cependant, les conséquences d’une inhalation chronique de propylène glycol sont méconnues. Avantageusement, les composés qui rendent la cigarette traditionnelle particulièrement nuisible – nitrosamines, formaldéhyde, métaux, monoxyde de carbone,… - sont soit absents, soit présents en faible quantité dans la vapeur d’une e-cigarette, sans comparaison avec les taux mesurés dans la fumée d’une cigarette conventionnelle. Il en résulte un profil de toxicité rassurant pour la e-cigarette, bien que son efficacité dans le sevrage tabagique reste à démontrer. [less ▲]

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See detailLes agents chélateurs : alerte à l'abus !
MISTRETTA, Virginie ULiege; CHARLIER, Corinne ULiege

in Revue Médicale de Liège (2016), 71(12), 551-556

L’exposition aux métaux lourds est un phénomène courant en raison de leur prévalence dans l’alimentation et dans l’environnement; leur toxicité demeure une préoccupation importante pour la santé publique ... [more ▼]

L’exposition aux métaux lourds est un phénomène courant en raison de leur prévalence dans l’alimentation et dans l’environnement; leur toxicité demeure une préoccupation importante pour la santé publique. Les agents chélateurs sont des substances chimiques utilisées pour augmenter l’élimination de certains métaux présents à des concentrations anormalement élevées dans l’organisme. Leurs indications cliniques approuvées sont limitées, particulièrement en raison des effets indésirables qu’ils peuvent induire. Malheureusement, trop souvent, les agents chélateurs sont utilisés avec pour objectif de vérifier le niveau d’imprégnation de l’organisme par les métaux lourds. Il s’agit d’un usage inapproprié et abusif. Afin d’attirer l’attention des praticiens sur cette problématique, les bons et les mauvais usages des chélateurs de métaux sont passés en revue [less ▲]

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See detailStrychnine poisoning still happens in 2015
DEVILLE, Marine ULiege; Lemaire, Eric ULiege; DENOOZ, Raphael ULiege et al

Conference (2016, August 29)

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See detailLes prothèses de hanche au cobalt sont-elles dangereuses ?
MISTRETTA, Virginie ULiege; KURTH, William ULiege; Charlier, Corinne ULiege

in Medecine Sciences : M/S (2016), 32(8-9), 732-738

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See detailLoss of treatment benefit when heroin-assisted treatment is stopped after 12 month
Demaret, Isabelle ULiege; Quertemont, Etienne ULiege; Litran, Géraldine et al

in Journal of Substance Abuse Treatment (2016), 69

Purpose: In 2013, during a recent heroin-assisted treatment trial, participants in heroinassisted treatment (HAT) decreased significantly more their street heroin use than participants in oral methadone ... [more ▼]

Purpose: In 2013, during a recent heroin-assisted treatment trial, participants in heroinassisted treatment (HAT) decreased significantly more their street heroin use than participants in oral methadone treatment. After the trial, HAT was discontinued. To examine whether the treatment benefits were sustained three months after the trial, the use of street heroin by the participants was analysed in a follow-up study. Results: At the follow-up assessment, street heroin use increased in the experimental group. The two groups no longer showed a significant difference (p=0.55) in the level of street heroin use. Conclusion: A predetermined and forced end of HAT was followed by a significant increase in the level of street level use. [less ▲]

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See detailA Simple Tiered Methodology for the Determination of Ambient Air Quality Guidelines
PIRARD, Catherine ULiege; Brouhon, Jean-Marc; Fourmeaux, Annick et al

in Clean : Soil, Air, Water (2016), 44(5), 464-473

Within the scope of the renewal of industrial operating permits in Belgium, the Walloon Agency for Air and Climate needed air quality criteria for a wide range of toxics. Due to the plethora of different ... [more ▼]

Within the scope of the renewal of industrial operating permits in Belgium, the Walloon Agency for Air and Climate needed air quality criteria for a wide range of toxics. Due to the plethora of different existing values for some compounds or the total lack for others, the development of a simple methodology was required to provide both quality and intervention criteria, corresponding respectively to a chemical concentration for which no adverse health effects are expected for a lifetime exposure, and the chemical concentration in air associated with a risk for human health deemed significant. The tiered methodology developed here allows the selection of air guidelines from available databases, and proposes, if needed, approaches based on well-proven procedures to derive air quality guidelines from occupational exposure limits, drinking water guidelines, tolerable daily intakes, or as a last resort acute lethal toxicity data if nothing else is available. If this method has been successfully applied to more than 550 compounds, all values produced should be validated according to the purpose of the guidelines, the technical feasibility of achieving the threshold produced, and the specificity of the environment conditions and the targeted population. Moreover, the criteria obtained from non-air-related data should be critically examined and handled with caution. [less ▲]

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See detailPostmortem Concentration and Redistribution of Diazepam, Methadone and Morphine with Subclavian and Femoral Vein Dissection/Clamping
Lemaire, Eric ULiege; Schmidt, Carl; DENOOZ, Raphael ULiege et al

in Journal of Forensic Sciences (2016), 61(6), 1596-1603

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