References of "CHANTRAINE, Frédéric"
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See detailExpulsion of a uterine myoma in a patient treated with ulipristal acetate
CHANTRAINE, Frédéric ULg; POISMANS, Gaëlle ULg; Nwachuku, Julia et al

in Clinical Case Reports (2015)

Description of a spontaneous expulsion of a submucosal myoma in a patient treated with ulipristal acetate.

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See detailIN UTERO INFECTION BY SCHMALLENBERG VIRUS INDUCES ARTHROGRYPOSIS MULTIPLEXA CONGENITA IN OVINE FETUSES
Boseret, Geraldine; Claine, Francoise; Coupeau, Damien et al

Poster (2014, December)

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See detailPREDICTION OF SHORT-TERM OUTCOME IN PREGNANT WOMEN WITH SUSPECTED PREECLAMPSIA: THE PROGNOSIS STUDY
Zeisler, Harald; Llurba, Elisa; CHANTRAINE, Frédéric ULg et al

Poster (2014, December)

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See detailSonographische Diagnostik bei abnorm invasiver Plazenta
Tutschek, Boris; CHANTRAINE, Frédéric ULg; Braun, Thorsten et al

in Der Gynäkologe (2014), 47

Abnormally invasive placenta (AIP or “mor- bidly adherent placenta”) significantly con- tributes to maternal morbidity and mortality , potentially causing severe hemorrhage at de- livery. Previous uterine ... [more ▼]

Abnormally invasive placenta (AIP or “mor- bidly adherent placenta”) significantly con- tributes to maternal morbidity and mortality , potentially causing severe hemorrhage at de- livery. Previous uterine surgery is the main risk factor. It may be speculated that with the rise in Caesarean delivery rates the incidence of AIP will also increase. Prenatal detection of AIP is mandatory to reduce the perinatal morbidity. Obstetrical ultrasound should be used as a screening tool for AIP. There are well known sonographic signs in B-mode, color Doppler and dynamic ultrasound that form the basis for prenatal detection. This review highlights these ultrasound markers and shows clinical examples. [less ▲]

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See detailResektion der Plazentahaftstelle bei pathologischer Plazentainvasion
CHANTRAINE, Frédéric ULg; PETIT, Philippe ULg; Langhoff-Roos, Jens

in Der Gynäkologe (2014), 47

Abnormally invasive placenta (AIP) is a rare condition with an increasing incidence. Severe cases, such as placenta percreta, can cause massive peripartal bleeding linked to an elevated maternal morbidity ... [more ▼]

Abnormally invasive placenta (AIP) is a rare condition with an increasing incidence. Severe cases, such as placenta percreta, can cause massive peripartal bleeding linked to an elevated maternal morbidity and even mortality. Prenatal AIP screening using ultra- sound allows referral to a specialized centre in suspected cases in order to optimize the chances for mother and child. Caesarean hys- terectomy or placenta in situ methods are the currently known and recommended management options. This article describes the techniques of elective resection of the placental bed including AIP which allow conserving the uterus and preserving fertility. Furthermore, it seems that morbidity of this technique is lower when compared to the standard treatment options. Whether this is due to a selection of less severe AIP cases for resection or really represents a lower complication rate in cases of resection has to be demonstrated by further prospective studies. [less ▲]

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See detailAn unusual presentation for congenital cytomegalovirus infection
Hennuy, Nadège; PIERART; Demarche, Martine et al

Poster (2014)

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See detailAIP (abnormally invasive placenta) – from a retained placenta to destruction of the uterine wall
Langhoff-Roos, Jens; CHANTRAINE, Frédéric ULg; Geirrson, Reynir

in Acta Obstetricia et Gynecologica Scandinavica (2013), 92(4), 367-8

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See detailIFPA Meeting 2012 Workshop Report III: trophoblast deportation, gestational trophoblastic disease, placental insufficiency and fetal growth restriction, trophoblast over-invasion and accreta-related pathologies, placental thrombosis and fibrinolysis.
Al-Khan, A.; Bulmer, J. N.; CHANTRAINE, Frédéric ULg et al

in Placenta (2013), 34 Suppl

Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2012 there were twelve themed workshops, five of which are summarized in this ... [more ▼]

Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2012 there were twelve themed workshops, five of which are summarized in this report. These workshops related to various aspects of placental biology but collectively covered areas of clinical research and pregnancy disorders: 1) trophoblast deportation; 2) gestational trophoblastic disease; 3) placental insufficiency and fetal growth restriction; 4) trophoblast overinvasion and accreta-related pathologies; 5) placental thrombosis and fibrinolysis. [less ▲]

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See detailPrenatal diagnosis of abnormally invasive placenta reduces maternal peripartum hemorrhage and morbidity.
CHANTRAINE, Frédéric ULg; Braun, Thorsten; Gonser, Markus et al

in Acta obstetricia et gynecologica Scandinavica (2013), 92(4), 439-44

OBJECTIVE: Abnormally invasive placenta (AIP) poses diagnostic and therapeutic challenges. We analyzed clinical cases with confirmed placenta increta or percreta. DESIGN: Retrospective case series ... [more ▼]

OBJECTIVE: Abnormally invasive placenta (AIP) poses diagnostic and therapeutic challenges. We analyzed clinical cases with confirmed placenta increta or percreta. DESIGN: Retrospective case series. SETTING: Multicenter study. POPULATION: Pregnant women with AIP. METHODS: Chart review. MAIN OUTCOME MEASURES: Prenatal detection rates, treatment choices, morbidity, mortality and short-term outcome. RESULTS: Sixty-six cases were analyzed. All women and all but three fetuses survived; 57/64 women (89%) had previous uterine surgery. In 26 women (39%) the diagnosis was not known before delivery (Group 1), in the remaining 40 (61%) diagnosis had been made between 14 and 37 weeks of gestation (Group 2). Placenta previa was present in 36 women (54%). In Groups 1 and 2, 50% (13/26) and 62% (25/40) of the women required hysterectomy, respectively. In Group 1 (unknown at the time of delivery) 69% (9/13) required (emergency) hysterectomy for severe hemorrhage in the immediate peripartum period compared with only 12% (3/25) in Group 2 (p = 0.0004). Mass transfusions were more frequently required in Group 1 (46%, 12/26 vs. 20%, 8/40; p = 0.025). In 18/40 women (45%) from Group 2 the placenta was intentionally left in situ; secondary hysterectomies and infections were equally frequent (18%) among these differently treated women. Overall, postpartum infections occurred in 11% and 20% of women in Groups 1 and 2, respectively. CONCLUSIONS: AIP was known before delivery in more than half of the cases. Unknown AIP led to significantly more emergency hysterectomies and mass transfusions during or immediately after delivery. Prenatal diagnosis of AIP reduces morbidity. Future studies should also address the selection criteria for cases appropriate for leaving the placenta in situ. [less ▲]

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See detailAbnormally invasive placenta--AIP. Awareness and pro-active management is necessary.
CHANTRAINE, Frédéric ULg; Langhoff-Roos, Jens

in Acta obstetricia et gynecologica Scandinavica (2013), 92(4), 369-71

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See detailQuantification of fetal head direction and descent.
Tutschek, B.; Braun, T.; CHANTRAINE, Frédéric ULg et al

in Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (2013), 41(1), 99-100

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See detailLE CAS CLINIQUE DU MOIS Le syndrome miroir : à propos d’un cas
Touhami, O.; CHANTRAINE, Frédéric ULg; DELBECQUE, Katty ULg et al

in Revue Médicale de Liège (2013), 68(9), 440-443

Mirror syndrome is a rare entity describing the association of foetal hydrops and maternal symptoms as general oedema and excessive weight gain mimicking preec- lampsia. We report the case of a patient ... [more ▼]

Mirror syndrome is a rare entity describing the association of foetal hydrops and maternal symptoms as general oedema and excessive weight gain mimicking preec- lampsia. We report the case of a patient who developed symptoms of oedema, weight gain, headache and biological hemodilution associated with foetal hydrops due to a com- plex congenital heart defect. This symptomatology spontane- ously resolved after foetal expulsion. Mirror or Ballantyne’s syndrome needs to be identified on time and well differenti- ated from preeclampsia. Its consequences may involve the maternal and foetal prognosis. [less ▲]

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See detailLe cas clinique du mois. L'adenomyose.
JASON, Maxime; DECHENNE, Valérie ULg; CHANTRAINE, Frédéric ULg et al

in Revue Médicale de Liège (2013), 68(4), 160-2

Adenomyosis is a medical benign condition of the endometrium-myometrium interface that is histopathologically characterized by the presence of ectopic tissue (endometrial glands and stroma) in myometrium ... [more ▼]

Adenomyosis is a medical benign condition of the endometrium-myometrium interface that is histopathologically characterized by the presence of ectopic tissue (endometrial glands and stroma) in myometrium. The diagnosis is complicated by the low specificity of its symptoms and the frequent associations with others gynaecologic pathologies. Consequently, paraclinic investigations are essential to make the diagnosis. [less ▲]

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See detailAssuétudes et grossesse: comment détruire un projet de naissance
Emonts, Patrick ULg; MASSON, Véronique ULg; CHANTRAINE, Frédéric ULg et al

in Revue Médicale de Liège (2013), 68(5-6), 239-244

Les femmes enceintes sont conscientes que toute forme d’addiction durant leur grossesse peut être préjudiciable à leur enfant. Pourtant, de nombreuses gestantes continuent de fumer, de boire de l’alcool ... [more ▼]

Les femmes enceintes sont conscientes que toute forme d’addiction durant leur grossesse peut être préjudiciable à leur enfant. Pourtant, de nombreuses gestantes continuent de fumer, de boire de l’alcool, de consommer des drogues illicites ou d’absorber des médicaments, car ces dépendances sont particulièrement tenaces. Le quatuor de tête en termes de préjudice fœtal est composé du tabac, de l’alcool, de la cocaïne et de l’ecstasy. La période de grossesse est le meilleur moment pour mettre fin à ces addictions. Aussi, est-il indispensable de sensibiliser le grand public, les pouvoirs politiques ainsi que les médecins sur le fait que les assuétudes durant la grossesse représentent une inégalité de santé et d’espérance de vie importante pour l’enfant à naître. [less ▲]

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See detailHysteroscopic resection of abnormally invasive placenta residuals.
Nisolle, Michelle ULg; DELBECQUE, Katty ULg; PERRIER d'HAUTERIVE, Sophie ULg et al

in Acta Obstetricia et Gynecologica Scandinavica (2013), 92(4), 451-6

OBJECTIVE: To present our experience in hysteroscopic removal of abnormally invasive placenta (AIP) residuals using bipolar energy. DESIGN: Case series. SETTING: University hospital. POPULATION: Sixteen ... [more ▼]

OBJECTIVE: To present our experience in hysteroscopic removal of abnormally invasive placenta (AIP) residuals using bipolar energy. DESIGN: Case series. SETTING: University hospital. POPULATION: Sixteen patients with AIP residuals after 17 pregnancies. METHODS: Cases were identified by ultrasound, treated with hysteroscopic bipolar electrosurgery and oral contraceptives, and followed up by ultrasound or hysteroscopy. Nine subsequent pregnancies were described. MAIN OUTCOME MEASURES AND RESULTS: Complete removal of AIP residuals was achieved by hysteroscopic bipolar electrosurgery in all cases except one. No peroperative complications occurred. AIP residual recurred in one patient after a subsequent pregnancy and was successfully treated using the same procedure. CONCLUSIONS: AIP residual is a rare condition. Management by hysteroscopic resection using bipolar energy is save and feasible. [less ▲]

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See detailExpression et localisation spatio-temporelle de KISS1 et de son récepteur KISSR dans le placenta normal et pathologique.
VALDES SOCIN, Hernan Gonzalo ULg; Munaut, Carine ULg; CHAVEZ, Viviana ULg et al

Poster (2012, October)

Objectif : Etudier l’expression de KISS1 (métastatine) et de son récepteur KISS1R lors de la grossesse normale et pathologique. Matériels et méthodes : Nous avons étudié la localisation de KISS1 et KISS1R ... [more ▼]

Objectif : Etudier l’expression de KISS1 (métastatine) et de son récepteur KISS1R lors de la grossesse normale et pathologique. Matériels et méthodes : Nous avons étudié la localisation de KISS1 et KISS1R par immunohistochimie dans des placentas normaux (1 er et 3 ème trimestre). Par RT-PCR quantitative, nous avons évalué le niveau d’expression des ARNm dans les placentas et les lits placentaires correspondants. Les niveaux d’expression de ARNm ont été comparés entre les grossesses normales (GN, n=13) et les grossesses spathologiques Prééclampsiques -PE-, n=17 et retard de croissance intrautérine -RCIU-, n=9). Résultats : Au premier trimestre des GN, KISS1 est majoritairement localisé dans les syncitiotrophoblastes, alors que KISS1R est détecté dans le mesenchyme villositaire. Au cours du troisième trimestre, KISS1 est uniquement localisé dans le syncitiotrophoblaste au contact avec la décidue et dans le mésenchyme villositaire et KISS1R est détecté dans le trophoblaste extra-villeux ainsi que dans quelques cellules de la décidue. Les analyses par RT-PCR mettent en évidence une expression plus importante des ARNm de KISS1 (p<0,001) et de KISS1R (p=0.039) dans les placentas (GN,PE et RCIU) par rapport aux lits placentaires correspondants. Les niveaux d’expression de KISS1 et KISS1R ne sont pas, cependant, significativement modulés dans les grossesses pathologiques. Conclusions : Par immunohistochimie, nos résultats indiquent une expression spatiotemporelle différente pour KISS1 et KISS1R entre le 1 er et 3 ème trimestre des grossesses normales. Nous n’avons pas mis en évidence de modulation de l’expression des ARNm dans les grossesses pathologiques. [less ▲]

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See detailTeaching and learning normal gynecological ultrasonography using simple virtual reality objects: a proposal for a standardized approach
Tutschek, Boris; CHANTRAINE, Frédéric ULg; Tercanli, Sevgi

in Ultrasound in Obstetrics & Gynecology (2012), 39

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See detailDifferential expression of Vegfr-2 and its soluble form in preeclampsia.
Munaut, Carine ULg; LORQUET, Sophie ULg; Pequeux, Christel ULg et al

in PLoS ONE (2012), 7(3), 33475

Background: Several studies have suggested that the main features of preeclampsia (PE) are consequences of endothelial dysfunction related to excess circulating anti-angiogenic factors, most notably ... [more ▼]

Background: Several studies have suggested that the main features of preeclampsia (PE) are consequences of endothelial dysfunction related to excess circulating anti-angiogenic factors, most notably, soluble sVEGFR-1 (also known as sFlt-1) and soluble endoglin (sEng), as well as to decreased PlGF. Recently, soluble VEGF type 2 receptor (sVEGFR-2) has emerged as a crucial regulator of lymphangiogenesis. To date, however, there is a paucity of information on the changes of VEGFR-2 that occur during the clinical onset of PE. Therefore, the aim of our study was to characterize the plasma levels of VEGFR-2 in PE patients and to perform VEGFR-2 immunolocalization in placenta. METHODOLOGY/PRINCIPAL FINDINGS: By ELISA, we observed that the VEGFR-2 plasma levels were reduced during PE compared with normal gestational age matched pregnancies, whereas the VEGFR-1 and Eng plasma levels were increased. The dramatic drop in the VEGFR-1 levels shortly after delivery confirmed its placental origin. In contrast, the plasma levels of Eng and VEGFR-2 decreased only moderately during the early postpartum period. An RT-PCR analysis showed that the relative levels of VEGFR-1, sVEGFR-1 and Eng mRNA were increased in the placentas of women with severe PE. The relative levels of VEGFR-2 mRNA as well as expressing cells, were similar in both groups. We also made the novel finding that a recently described alternatively spliced VEGFR-2 mRNA variant was present at lower relative levels in the preeclamptic placentas. CONCLUSIONS/SIGNIFICANCE: Our results indicate that the plasma levels of anti-angiogenic factors, particularly VEGFR-1 and VEGFR-2, behave in different ways after delivery. The rapid decrease in plasma VEGFR-1 levels appears to be a consequence of the delivery of the placenta. The persistent circulating levels of VEGFR-2 suggest a maternal endothelial origin of this peptide. The decreased VEGFR-2 plasma levels in preeclamptic women may serve as a marker of endothelial dysfunction. [less ▲]

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See detailIndividual decisions in placenta increta and percreta: a case series.
CHANTRAINE, Frédéric ULg; NISOLLE, Michelle ULg; PETIT, Philippe ULg et al

in Journal of Perinatal Medicine (2012), 40(3), 265-70

Abstract Objective: Placenta increta or percreta is an uncommon pathology, sometimes associated with high maternal morbidity. Its prevalence increases proportionally to the number of cesarean sections ... [more ▼]

Abstract Objective: Placenta increta or percreta is an uncommon pathology, sometimes associated with high maternal morbidity. Its prevalence increases proportionally to the number of cesarean sections. This study analyzed the changes of our management strategy to devise treatment guidelines for this uncommon disorder. Materials and methodology: Between 2005 and 2011, 10 cases of placenta increta or percreta were managed at our university hospital maternity department. Results: Among the 10 cases, seven were diagnosed prenatally. Two patients were diagnosed early, at 14 and 17 weeks of gestational age, and their pregnancies were terminated. Five had hysterectomies during the intrapartum period, and despite attempted conservative treatment for the two others, hysterectomy proved necessary 2 months postpartum because of intrauterine infections. Seven of the 10 women had hysterectomies. Conclusion: Prenatal diagnosis of placenta increta or percreta is essential to plan the delivery in a competent tertiary care center. The decision to perform a cesarean hysterectomy or leave the placenta in situ for spontaneous delivery is based on the extent of infiltration, the patient's hemodynamic status, and her desire to remain fertile. The high-risk of infection and severe hemorrhage must not be overlooked should conservative treatment be chosen. This situation requires prolonged close monitoring. [less ▲]

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