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See detailExclusive Ubiquitination And Sumoylation On Overlapping Lysine Residues Mediate Nf-Kappa B Activation By The Human T-Cell Leukemia Virus Tax Oncoprotein
Lamsoul, I.; Lodewick, J.; Lebrun, S. et al

in Molecular and Cellular Biology (2005), 25(23), 10391-406

The transcription factor NF-kappaB is critical for the induction of cancer, including adult T-cell leukemia, which is linked to infection by human T-cell leukemia virus type 1 and the expression of its ... [more ▼]

The transcription factor NF-kappaB is critical for the induction of cancer, including adult T-cell leukemia, which is linked to infection by human T-cell leukemia virus type 1 and the expression of its regulatory protein Tax. Although activation of the NF-kappaB pathway by Tax involves its interaction with the regulatory subunit of the IkappaB kinase (IKK) complex, NEMO/IKKgamma, the mechanism by which Tax activates specific cellular genes in the nucleus remains unknown. Here, we demonstrate that the attachment of SUMO-1 to Tax regulates its localization in nuclear bodies and the recruitment of both the RelA subunit of NF-kappaB and free IKKgamma in these nuclear structures. However, this sumoylation step is not sufficient for the activation of the NF-kappaB pathway by Tax. This activity requires the prior ubiquitination and colocalization of ubiquitinated Tax with IKK complexes in the cytoplasm and the subsequent migration of the RelA subunit of NF-kappaB to the nucleus. Thus, the ubiquitination and sumoylation of Tax function in concert to result in the migration of RelA to the nucleus and its accumulation with IKKgamma in nuclear bodies for activation of gene expression. These modifications may result in targets for the treatment of adult T-cell leukemia. [less ▲]

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See detailExpression In A Rabgap Yeast Mutant Of Two Human Homologues, One Of Which Is An Oncogene
Bizimungu, C.; De Neve, N.; Burny, A. et al

in Biochemical and Biophysical Research Communications (2003), 310(2),

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See detailReduced Cell Turnover In Bovine Leukemia Virus-Infected, Persistently Lymphocytotic Cattle
Debacq, C.; Asquith, B.; Reichert, M. et al

in Journal of Virology (2003), 77(24),

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See detailBovine Leukemia Virus Su Protein Interacts With Zinc, And Mutations Within Two Interacting Regions Differentially Affect Viral Fusion And Infectivity In Vivo
Gatot, Js.; Callebaut, I.; Van Lint, C. et al

in Journal of Virology (2002), 76(16),

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See detailIncreased Cell Proliferation, But Not Reduced Cell Death, Induces Lymphocytosis In Bovine Leukemia Virus-Infected Sheep
Debacq, C.; Asquith, B.; Kerkhofs, P. et al

in Proceedings of the National Academy of Sciences of the United States of America (2002), 99(15),

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See detailSuboptimal Enhancer Sequences Are Required For Efficient Bovine Leukemia Virus Propagation In Vivo: Implications For Viral Latency
Merezak, C.; Pierreux, C.; Adam, E. et al

in Journal of Virology (2001), 75(15),

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See detailGenetic Determinants Of Bovine Leukemia Virus Pathogenesis
Willems, Luc ULg; Burny, A.; Collete, Delphine et al

in Aids Research and Human Retroviruses (2000), 16(16), 1787-95

The understanding of HTLV-induced disease is hampered by the lack of a suitable animal model allowing the study of both viral replication and leukemogenesis in vivo. Although valuable information has been ... [more ▼]

The understanding of HTLV-induced disease is hampered by the lack of a suitable animal model allowing the study of both viral replication and leukemogenesis in vivo. Although valuable information has been obtained in different species, such as rabbits, mice, rats, and monkeys, none of these systems was able to conciliate topics as different as viral infectivity, propagation within the host, and generation of leukemic cells. An alternate strategy is based on the understanding of diseases induced by viruses closely related to HTLV-1, like bovine leukemia virus (BLV). Both viruses indeed belong to the same subfamily of retroviruses, harbor a similar genomic organization, and infect and transform cells of the hematopoietic system. The main advantage of the BLV system is that it allows direct experimentation in two different species, cattle and sheep. [less ▲]

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See detailDexamethasone Ester Treatment Alters Insulin-Like Growth Factor-I, Its Binding Proteins And Thyroid Status In Finishing Calves
Bertozzi, C.; Portetelle, Daniel ULg; Massart, Serge et al

in Canadian Journal of Animal Science (2000), 80(2),

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See detailLong-Term Protection Against Bovine Leukaemia Virus Replication In Cattle And Sheep
Kerkhofs, P.; Gatot, Js.; Knapen, K. et al

in Journal of General Virology (2000), 81

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See detailBovine leukemia virus as a model for human T-cell leukemia virus
Willems, Luc ULg; Burny, A.; Dangoisse, O. et al

in Current Topics in Virology (1999)

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See detailBovine Leukemia Virus-Induced Persistent Lymphocytosis In Cattle Does Not Correlate With Increased Ex Vivo Survival Of B Lymphocytes
Dequiedt, Franck ULg; Cantor, Gh.; Hamilton, Vt. et al

in Journal of Virology (1999), 73(2),

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See detailLeukemia Viruses
Burny, A.; Bex, F.; Dequiedt, Franck ULg et al

in Encyclopedia of Immunology, Academic Press (1998)

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See detailIn Vitro And In Vivo Oncogenic Potential Of Bovine Leukemia Virus G4 Protein
Kerkhofs, P.; Heremans, H.; Burny, A. et al

in Journal of Virology (1998), 72(3),

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See detailEvaluation Of The Genetic Variability Of 23 Bovine Microsatellite Markers In Four Belgian Cattle Breeds
Peelman, Lj.; Mortiaux, F.; Van Zeveren, A. et al

in Animal Genetics (1998), 29(3),

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See detailConservative Mutations In The Immunosuppressive Region Of The Bovine Leukemia Virus Transmembrane Protein Affect Fusion But Not Infectivity In Vivo
Gatot, Js.; Callebaut, I.; Mornon, Jp. et al

in Journal of Biological Chemistry (1998), 273(21),

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